Allele Dmel\Gad1^E143K

General Information
Symbol	Dmel\Gad1^E143K	Species	D. melanogaster
Name		FlyBase ID	FBal0119483
Feature type	allele	Associated gene	Dmel\Gad1

Map ( GBrowse )
Allele class
Mutagen
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen
Mutations Mapped to the Genome

Type Location Additional Notes References point mutation 3L:4,079,366..4,079,366 comment=Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. evidence=experimental pr_change=E143K\|Gad1-PA,E143K\|Gad1-PB,E143K\|Gad1-PC reported_pr_change=E143K na_change=G4079366A (Featherstone et al., 2000)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: E143K. (Featherstone et al., 2000)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| embryonic stage \| recessive (Featherstone et al., 2000) locomotor behavior defective (Featherstone et al., 2000)
Phenotype Manifest In

Detailed Description
	Statement Reference Those few homozygous animals that do survive to hatch, diplay grossly abnormal movement and behaviour and always die as early as first instar larvae. (Featherstone et al., 2000)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescued by	Gad1^E143K is rescued by Gad1^Scer\UAS.cFa/Scer\GAL4^elav.PLu (Featherstone et al., 2000)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	D1 (Featherstone et al., 2000) E143K (Featherstone et al., 2000) Gad1^E143K
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Featherstone et al., 2000, Neuron 27(1): 71--84 Presynaptic glutamic acid decarboxylase is required for induction of the postsynaptic receptor field at a glutamatergic synapse. [FBrf0130303]

Allele Dmel\Gad1E143K

Allele Dmel\Gad1^E143K