Allele Dmel\ban^EP3208

General Information
Symbol	Dmel\ban^EP3208	Species	D. melanogaster
Name		FlyBase ID	FBal0119632
Feature type	allele	Associated gene	Dmel\ban

Map ( GBrowse )	Untitled Document
Allele class
Mutagen	P-element activity
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	P-element activity (Abdelilah-Seyfried et al., 2000, Gene Disruption Project members, 2001-, Kraut et al., 2001, Hipfner et al., 2002)
Mutations Mapped to the Genome

Type Location Additional Notes References transposable element insertion site 3L:637,528..637,528 (Abdelilah-Seyfried et al., 2000, Hipfner et al., 2002, Bilen et al., 2006, Gene Disruption Project members, 2001-, Kraut et al., 2001)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Caused by insertion	P{EP}ban^EP3208 (Abdelilah-Seyfried et al., 2000, Hipfner et al., 2002, Bilen et al., 2006, Gene Disruption Project members, 2001-, Kraut et al., 2001)
Cytology
Phenotypic Data
Phenotypic Class
	female sterile (with Df(3L)ban^Δ1), with Scer\GAL4[-]: (Hipfner et al., 2002) neuroanatomy defective \| larval stage, with Scer\GAL4^elav-C155 (Kraut et al., 2001) small body (with Df(3L)ban^Δ1), with Scer\GAL4[-]: (Hipfner et al., 2002) viable (with Df(3L)ban^Δ1), with Scer\GAL4[-]: (Hipfner et al., 2002) visible, with Scer\GAL4^sca-537.4 (Abdelilah-Seyfried et al., 2000)
Phenotype Manifest In
	anterior fascicle & synapse, with Scer\GAL4^elav-C155 (Kraut et al., 2001) intersegmental nerve, with Scer\GAL4^elav-C155 (Kraut et al., 2001) scutellar bristle \| ectopic, with Scer\GAL4^sca-537.4 (Abdelilah-Seyfried et al., 2000) tormogen cell, with Scer\GAL4^sca-537.4 (Abdelilah-Seyfried et al., 2000) wing, with Scer\GAL4^en-e16E (Hipfner et al., 2002)
Detailed Description
	Statement Reference The body mass of ban^EP3208/Df(3L)ban^Δ1 adults is only 89% of that of control flies. Expression of ban^EP3208 under the control of Scer\GAL4^en-e16E results in a significant increase in the ratio of posterior:anterior area of the wing compared to control wings. There is no increase in overall wing size. (Hipfner et al., 2002) Mutant larvae expressing ban^EP3208 under the control of Scer\GAL4^elav-C155 have reduced or abnormal synapses. Mutant larvae expressing ban^EP3208 under the control of Scer\GAL4^elav-C155 have ISN neuron pathfinding defects. (Kraut et al., 2001) Expression of ban^EP3208 under the control of Scer\GAL4^sca-537.4 results in additional scutellar macrochaetae. Sensory organs with no socket and one shaft are seen. (Abdelilah-Seyfried et al., 2000)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhanced by
Statement Reference Scer\GAL4^sca-537.4, ban^EP3208 has visible phenotype, non-enhanceable by H[+]/H^E21 (Abdelilah-Seyfried et al., 2000) Scer\GAL4^sca-537.4, ban^EP3208 has visible phenotype, non-enhanceable by N[+]/N^55e11 (Abdelilah-Seyfried et al., 2000)
NOT suppressed by
Statement Reference Scer\GAL4^sca-537.4, ban^EP3208 has visible phenotype, non-suppressible by H[+]/H^E21 (Abdelilah-Seyfried et al., 2000) Scer\GAL4^sca-537.4, ban^EP3208 has visible phenotype, non-suppressible by N[+]/N^55e11 (Abdelilah-Seyfried et al., 2000)
Enhancer of
Statement Reference ban^EP3208/Df(3L)ban^Δ1 is an enhancer of increased cell death phenotype of Hsap\ATXN3^{tr.Q78.GMR.T:Ivir\HA1} (Bilen et al., 2006)
Phenotype Manifest In
Enhancer of
Statement Reference ban^EP3208/Df(3L)ban^Δ1 is an enhancer of eye phenotype of Hsap\ATXN3^{tr.Q78.GMR.T:Ivir\HA1} (Bilen et al., 2006) ban^EP3208/Df(3L)ban^Δ1 is an enhancer of retina phenotype of Hsap\ATXN3^{tr.Q78.GMR.T:Ivir\HA1} (Bilen et al., 2006)
NOT Enhancer of
Statement Reference ban^EP3208/Scer\GAL4^sca-537.4 is a non-enhancer of phenotype of H^E21 (Abdelilah-Seyfried et al., 2000) ban^EP3208/Scer\GAL4^sca-537.4 is a non-enhancer of phenotype of N^55e11 (Abdelilah-Seyfried et al., 2000)
NOT Suppressor of
Statement Reference ban^EP3208/Scer\GAL4^sca-537.4 is a non-suppressor of phenotype of H^E21 (Abdelilah-Seyfried et al., 2000)
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference Reduction of ban activity through ban[EP3208]/Df(3L)ban[Δ1] enhances Hsap\MJD[tr.Q78.GMR.T:Ivir\HA1]-induced degeneration, such that flies are now born with more neuronal loss. (Bilen et al., 2006)
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer
	Separable from: a lethal mutation at another locus on the chromosome. (Hipfner et al., 2002)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	ban^EP3208 EP3208^EP3208 (Kraut et al., 2001, ) EP(3)3208 (Abdelilah-Seyfried et al., 2000)
Name Synonym
Secondary FlyBase IDs

References ( 5 )
Research paper	Bilen et al., 2006, Mol. Cell 24(1): 157--163 MicroRNA pathways modulate polyglutamine-induced neurodegeneration. [FBrf0192284] Hipfner et al., 2002, Genetics 161(4): 1527--1537 The bantam gene regulates Drosophila growth. [FBrf0152024] Abdelilah-Seyfried et al., 2000, Genetics 155(2): 733--752 A gain-of-function screen for genes that affect the development of the Drosophila adult external sensory organ. [FBrf0128367]
Supplementary material	Kraut et al., 2001, Curr. Biol. 11(6): A gain-of-function screen for genes controlling motor axon guidance and synaptogenesis in Drosophila. [FBrf0135968]
Personal communication to FlyBase	Gene Disruption Project members, 2001-, (Computer file) (Computer file) [FBrf0132177]

Allele Dmel\banEP3208

Allele Dmel\ban^EP3208