FlyBase Allele Report: Dmel\bchs[EP2299]

General Information

Symbol

Dmel\bchs^EP2299

Species

D. melanogaster

Name

FlyBase ID

FBal0119642

Feature type

allele

Associated gene

Dmel\bchs

Associated Insertion(s)

P{EP}EP2299

Carried in Construct

Also Known As

EP(2)2299, EP(2L)2299, bchs⁴

Genomic Maps

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Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Kraut et al., 2001, Kraut et al., 2001)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

transposable element insertion site

2L:5,907,523..5,907,523 [+]

(Sim et al., 2019, Hasanagic et al., 2015, Hebbar et al., 2015, Luan et al., 2012, Eissenberg et al., 2011, Kriston-Vizi et al., 2011, Simonsen et al., 2007, Khodosh et al., 2006, Raymond et al., 2004, Finley et al., 2003, Gene Disruption Project members, 2001-, Kraut et al., 2001, Kraut et al., 2001, Abdelilah-Seyfried et al., 2000)

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Cytology

Nature of the lesion

Statement

Reference

Single insertion within the first intron, upstream of the bchs open reading frame.

(Simonsen et al., 2007)

The P{EP} element is inserted 829 nucleotides 5' to the predicted ATG start codon of CG14001.

(Kraut et al., 2001)

Insertion components

P{EP}EP2299

Product class / Tool use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

misexpression element

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Phenotypic Data

Phenotypic Class

female fertile, with Scer\GAL4^- :

(Finley et al., 2003)

male fertile, with Scer\GAL4^- :

(Finley et al., 2003)

neuroanatomy defective, with Scer\GAL4^elav-C155

(Kraut et al., 2001)

neuroanatomy defective, with Scer\GAL4^GMR.PF

(Eissenberg et al., 2011)

neuroanatomy defective | adult stage (with Df(2L)cl7), with Scer\GAL4^- :

(Finley et al., 2003)

neuroanatomy defective | larval stage, with Scer\GAL4^elav-C155

(Kraut et al., 2001)

short lived, with Scer\GAL4^- :

(Finley et al., 2003)

short lived (with Df(2L)cl7), with Scer\GAL4^- :

(Finley et al., 2003)

visible, with Scer\GAL4^GMR.PF

(Hasanagic et al., 2015, Simonsen et al., 2007, Müller et al., 2005)

visible, with Scer\GAL4^GMR.PU

(Raymond et al., 2004)

visible, with Scer\GAL4^sca-537.4

(Abdelilah-Seyfried et al., 2000)

Phenotype Manifest In

adult abdomen & microchaeta, with Scer\GAL4^sca-537.4

(Abdelilah-Seyfried et al., 2000)

adult central nervous system, with Scer\GAL4^- :

(Finley et al., 2003)

adult central nervous system (with Df(2L)cl7), with Scer\GAL4^- :

(Finley et al., 2003)

anterior fascicle & synapse, with Scer\GAL4^elav-C155

(Kraut et al., 2001, Kraut et al., 2001)

dorsocentral bristle, with Scer\GAL4^sca-537.4

(Abdelilah-Seyfried et al., 2000)

embryonic/larval brain | third instar larval stage, with Scer\GAL4^elav-C155

(Kriston-Vizi et al., 2011)

eye, with Scer\GAL4^GMR.PF

(Hasanagic et al., 2015, Eissenberg et al., 2011, Simonsen et al., 2007, Khodosh et al., 2006, Müller et al., 2005)

eye, with Scer\GAL4^GMR.PU

(Raymond et al., 2004)

growth cone, with Scer\GAL4^GMR.PF

(Khodosh et al., 2006)

growth cone & eye photoreceptor cell, with Scer\GAL4^GMR.PF

(Simonsen et al., 2007)

intersegmental nerve, with Scer\GAL4^elav-C155

(Kraut et al., 2001)

neuron & eye photoreceptor cell, with Scer\GAL4^GMR.PF

(Simonsen et al., 2007)

ommatidium, with Scer\GAL4^GMR.PF

(Khodosh et al., 2006)

scutellar bristle, with Scer\GAL4^sca-537.4

(Abdelilah-Seyfried et al., 2000)

Detailed Description

Statement

Reference

Overexpression of bchs^EP2299 under the control of Scer\GAL4^GMR.PF engenders a reduced eye phenotype.

(Hasanagic et al., 2015)

Overexpression of bchs^EP2299 in the eye under the control of Scer\GAL4^GMR.PF results in a rough eye phenotype and age related neuronal degeneration.

(Eissenberg et al., 2011)

Expression of bchs^EP2299 in the developing nervous system, driven by Scer\GAL4^elav-C155 results in a 14.6% increase in brain volume when compared to controls.

(Kriston-Vizi et al., 2011)

Flies expressing bchs^EP2299 under the control of Scer\GAL4^GMR.PF have a roughened eye surface and a slight decrease in overall eye size compared to controls.

Animals expressing bchs^EP2299 under the control of Scer\GAL4^GMR.PF show alterations in the neural projection patterns of photoreceptor cells compared to wild-type in mid-pupae; the number and basic array of R7 and R8 axonal projections remain relatively normal, but there is a loss of growth cone morphology, premature termination of developing synapses and axonal swellings or varicosities are seen.

(Simonsen et al., 2007)

Expression of bchs^EP2299 in third instar eye discs, under the control of Scer\GAL4^GMR.PF, does not affect the patterning of the disc. Expression in the developing retina results in photoreceptor growth cones with an unusually bulbous central region that are less expanded than wild-type growth cones. However, Scer\GAL4^GMR.PF>bchs^EP2299 growth cones appear to grow normally towards their targets. At the adult stage, flies of this genotype have small, glazed eyes that lack distinct ommatidia compared to those of wild-type flies.

(Khodosh et al., 2006)

Expression of bchs^EP2299 under the control of Scer\GAL4^GMR.PF results in smaller eyes than normal which have a glossy appearance.

(Müller et al., 2005)

Expression of bchs^EP2299 under the control of Scer\GAL4^GMR.PU results in a rough eye phenotype.

(Raymond et al., 2004)

bchs^EP2299 homozygotes and bchs^EP2299/Df(2L)cl7 flies have a reduced average lifespan compared to wild-type. These flies also have age-dependent ubiquitinated aggregates, that appear to be insoluble, throughout the CNS.

(Finley et al., 2003)

Mutant larvae expressing bchs^EP2299 under the control of Scer\GAL4^elav-C155 have reduced or abnormal synapses.

(Kraut et al., 2001)

Mutant larvae expressing bchs^EP2299 under the control of Scer\GAL4^elav-C155 have altered ISN synapses with abnormal bulges at the junctions between the axons and the synaptic branches.

(Kraut et al., 2001)

Expression of bchs^EP2299 under the control of Scer\GAL4^sca-537.4 results in severe loss of microchaetae on the abdomen and loss of scutellar and dorsocentral macrochaetae. Sensory organs with one socket, no shaft and one sheath cell are seen.

(Abdelilah-Seyfried et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has visible phenotype, enhanceable by Lerp^F6

(Hasanagic et al., 2015)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has visible phenotype, enhanceable by Lerp^F6/Df(3R)BSC524

(Hasanagic et al., 2015)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has neuroanatomy defective phenotype, enhanceable by Gga^dsRNA.UAS.1, Scer\GAL4^GMR.PF

(Eissenberg et al., 2011)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has visible phenotype, enhanceable by Rab11^93Bi/Rab11[+]

(Simonsen et al., 2007)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has visible phenotype, enhanceable by Rab11^j2D1/Rab11[+]

(Simonsen et al., 2007)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has visible phenotype, enhanceable by Atg1[+]/Atg1⁰⁰³⁰⁵

(Simonsen et al., 2007)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has visible phenotype, enhanceable by Atg6[+]/Atg6⁰⁰⁰⁹⁶

(Simonsen et al., 2007)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has visible phenotype, enhanceable by Atg18a^KG03090/Atg18[+]

(Simonsen et al., 2007)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has visible phenotype, enhanceable by or^49h/or[+]

(Simonsen et al., 2007)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has visible phenotype, enhanceable by spin^k09905/spin[+]

(Simonsen et al., 2007)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has visible phenotype, enhanceable by dor¹/dor⁺

(Simonsen et al., 2007)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has visible phenotype, enhanceable by dor⁴/dor⁺

(Simonsen et al., 2007)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has visible phenotype, enhanceable by dor⁸/dor⁺

(Simonsen et al., 2007)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has visible phenotype, enhanceable by car[+]/car¹

(Simonsen et al., 2007)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has visible phenotype, enhanceable by Rop^G27/Rop[+]

(Simonsen et al., 2007)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has visible phenotype, enhanceable by Syx1A^Δ229/Syx1A[+]

(Simonsen et al., 2007)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has visible phenotype, enhanceable by Syx13⁰¹⁴⁷⁰/Syx13[+]

(Simonsen et al., 2007)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has visible phenotype, enhanceable by hk[+]/hook¹

(Simonsen et al., 2007)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has visible phenotype, enhanceable by Rab32¹/ltd[+]

(Simonsen et al., 2007)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has visible phenotype, enhanceable by ca¹/ca[+]

(Simonsen et al., 2007)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has visible phenotype, enhanceable by Dlic^G0190/Dlic2[+]

(Simonsen et al., 2007)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has visible phenotype, enhanceable by Dlic^G0065/Dlic2[+]

(Simonsen et al., 2007)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has visible phenotype, enhanceable by btv^BG01771/btv[+]

(Simonsen et al., 2007)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has visible phenotype, enhanceable by alphaTub84B[+]/αTub84B⁵

(Simonsen et al., 2007)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has visible phenotype, enhanceable by alphaTub84B[+]/αTub84B⁷

(Simonsen et al., 2007)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has visible phenotype, enhanceable by smt3^k06307/smt3[+]

(Simonsen et al., 2007)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has visible phenotype, enhanceable by lwr⁰⁵⁴⁸⁶/lwr[+]

(Simonsen et al., 2007)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has visible phenotype, enhanceable by Uba1[+]/Uba1^s3484

(Simonsen et al., 2007)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has visible phenotype, enhanceable by eff^mer1/eff[+]

(Simonsen et al., 2007)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has visible phenotype, enhanceable by Usp7^KG06814/Usp7[+]

(Simonsen et al., 2007)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has visible phenotype, enhanceable by or[+]/or¹

(Simonsen et al., 2007)

NOT Enhanced by

Statement

Reference

Scer\GAL4^sca-537.4, bchs^EP2299 has visible phenotype, non-enhanceable by H[+]/H^E21

(Abdelilah-Seyfried et al., 2000)

Scer\GAL4^sca-537.4, bchs^EP2299 has visible phenotype, non-enhanceable by N[+]/N^55e11

(Abdelilah-Seyfried et al., 2000)

Suppressed by

Statement

Reference

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has visible phenotype, suppressible by Atg2^EP3697, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Simonsen et al., 2007)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has visible phenotype, suppressible by Atg8a^EP362, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Simonsen et al., 2007)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has visible phenotype, suppressible by Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF/Diap1^UAS.cMa

(Müller et al., 2005)

NOT suppressed by

Statement

Reference

Scer\GAL4^sca-537.4, bchs^EP2299 has visible phenotype, non-suppressible by H[+]/H^E21

(Abdelilah-Seyfried et al., 2000)

Scer\GAL4^sca-537.4, bchs^EP2299 has visible phenotype, non-suppressible by N[+]/N^55e11

(Abdelilah-Seyfried et al., 2000)

Enhancer of

Statement

Reference

bchs^EP2299, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF is an enhancer of visible phenotype of H^Scer\UAS.cMa/H^UAS.cMa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Müller et al., 2005)

bchs^EP2299, Scer\GAL4^GMR.PU is an enhancer of visible phenotype of RacGAP84C^GAP.UAS, Scer\GAL4^GMR.PU

(Raymond et al., 2004)

bchs^EP2299, Scer\GAL4^GMR.PU is an enhancer of visible phenotype of Rac1^N17.UAS, Scer\GAL4^GMR.PU

(Raymond et al., 2004)

bchs^EP2299, Scer\GAL4^GMR.PU is an enhancer of visible phenotype of Cdc42^N17.UAS, Scer\GAL4^GMR.PU

(Raymond et al., 2004)

bchs^EP2299, Scer\GAL4^GMR.PU is an enhancer of visible phenotype of Ras85D^N17.UAS, Scer\GAL4^GMR.PU

(Raymond et al., 2004)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has eye phenotype, enhanceable by Lerp^F6

(Hasanagic et al., 2015)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has eye phenotype, enhanceable by Lerp^F6/Df(3R)BSC524

(Hasanagic et al., 2015)

Scer\GAL4^GMR.PU, bchs^EP2299 has eye phenotype, enhanceable by Gga^Δ

(Luan et al., 2012)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has eye phenotype, enhanceable by Gga^dsRNA.UAS.1, Scer\GAL4^GMR.PF

(Eissenberg et al., 2011)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has eye phenotype, enhanceable by Rab11^j2D1/Rab11[+]

(Simonsen et al., 2007, Khodosh et al., 2006)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has eye phenotype, enhanceable by Rab11^93Bi/Rab11[+]

(Simonsen et al., 2007, Khodosh et al., 2006)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has eye phenotype, enhanceable by Atg1[+]/Atg1⁰⁰³⁰⁵

(Simonsen et al., 2007)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has eye phenotype, enhanceable by Atg6[+]/Atg6⁰⁰⁰⁹⁶

(Simonsen et al., 2007)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has eye phenotype, enhanceable by Atg18a^KG03090/Atg18[+]

(Simonsen et al., 2007)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has eye phenotype, enhanceable by or^49h/or[+]

(Simonsen et al., 2007)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has eye phenotype, enhanceable by spin^k09905/spin[+]

(Simonsen et al., 2007)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has eye phenotype, enhanceable by dor¹/dor⁺

(Simonsen et al., 2007)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has eye phenotype, enhanceable by dor⁴/dor⁺

(Simonsen et al., 2007)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has eye phenotype, enhanceable by dor⁸/dor⁺

(Simonsen et al., 2007)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has eye phenotype, enhanceable by car[+]/car¹

(Simonsen et al., 2007)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has eye phenotype, enhanceable by Rop^G27/Rop[+]

(Simonsen et al., 2007)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has eye phenotype, enhanceable by Syx1A^Δ229/Syx1A[+]

(Simonsen et al., 2007)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has eye phenotype, enhanceable by Syx13⁰¹⁴⁷⁰/Syx13[+]

(Simonsen et al., 2007)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has eye phenotype, enhanceable by hk[+]/hook¹

(Simonsen et al., 2007)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has eye phenotype, enhanceable by Rab32¹/ltd[+]

(Simonsen et al., 2007)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has eye phenotype, enhanceable by ca¹/ca[+]

(Simonsen et al., 2007)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has eye phenotype, enhanceable by Dlic^G0190/Dlic2[+]

(Simonsen et al., 2007)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has eye phenotype, enhanceable by Dlic^G0065/Dlic2[+]

(Simonsen et al., 2007)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has eye phenotype, enhanceable by btv^BG01771/btv[+]

(Simonsen et al., 2007)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has eye phenotype, enhanceable by alphaTub84B[+]/αTub84B⁵

(Simonsen et al., 2007)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has eye phenotype, enhanceable by alphaTub84B[+]/αTub84B⁷

(Simonsen et al., 2007)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has eye phenotype, enhanceable by smt3^k06307/smt3[+]

(Simonsen et al., 2007)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has eye phenotype, enhanceable by lwr⁰⁵⁴⁸⁶/lwr[+]

(Simonsen et al., 2007)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has eye phenotype, enhanceable by Uba1[+]/Uba1^s3484

(Simonsen et al., 2007)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has eye phenotype, enhanceable by eff^mer1/eff[+]

(Simonsen et al., 2007)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has eye phenotype, enhanceable by Usp7^KG06814/Usp7[+]

(Simonsen et al., 2007)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has eye phenotype, enhanceable by or[+]/or¹

(Simonsen et al., 2007)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has eye phenotype, enhanceable by Rab11[+]/Rab11^ex1

(Khodosh et al., 2006)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has eye phenotype, enhanceable by Rab11^ex2/Rab11[+]

(Khodosh et al., 2006)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has eye phenotype, enhanceable by Rab11^ETo11/Rab11[+]

(Khodosh et al., 2006)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has eye phenotype, enhanceable by Df(3R)e-R1

(Khodosh et al., 2006)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has eye phenotype, enhanceable by Rab11[+]/Rab11^ETo3

(Khodosh et al., 2006)

Suppressed by

Statement

Reference

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has eye phenotype, suppressible by Atg2^EP3697, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Simonsen et al., 2007)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has eye phenotype, suppressible by Atg8a^EP362, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Simonsen et al., 2007)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 has eye phenotype, suppressible by Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF/Diap1^UAS.cMa

(Müller et al., 2005)

Enhancer of

Statement

Reference

bchs^EP2299, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF is an enhancer of eye phenotype of H^Scer\UAS.cMa/H^UAS.cMa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Müller et al., 2005)

bchs^EP2299, Scer\GAL4^GMR.PU is an enhancer of eye phenotype of RacGAP84C^GAP.UAS, Scer\GAL4^GMR.PU

(Raymond et al., 2004)

bchs^EP2299, Scer\GAL4^GMR.PU is an enhancer of eye phenotype of Rac1^N17.UAS, Scer\GAL4^GMR.PU

(Raymond et al., 2004)

bchs^EP2299, Scer\GAL4^GMR.PU is an enhancer of eye phenotype of Cdc42^N17.UAS, Scer\GAL4^GMR.PU

(Raymond et al., 2004)

bchs^EP2299, Scer\GAL4^GMR.PU is an enhancer of eye phenotype of Ras85D^N17.UAS, Scer\GAL4^GMR.PU

(Raymond et al., 2004)

NOT Enhancer of

Statement

Reference

bchs^EP2299/Scer\GAL4^sca-537.4 is a non-enhancer of phenotype of N^55e11

(Abdelilah-Seyfried et al., 2000)

bchs^EP2299/Scer\GAL4^sca-537.4 is a non-enhancer of phenotype of H^E21

(Abdelilah-Seyfried et al., 2000)

NOT Suppressor of

Statement

Reference

bchs^EP2299/Scer\GAL4^sca-537.4 is a non-suppressor of phenotype of H^E21

(Abdelilah-Seyfried et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

Homo- and hemizygous Lerp^F6 enhances the reduced eye phenotype caused by bchs^EP2299 overexpression.

(Hasanagic et al., 2015)

The bchs^EP2299-overexpression phenotype in the eye is enhanced when Gga^{dsRNA.Scer\UAS.1} is co-expressed under the control of Scer\GAL4^GMR.PF resulting in a reduction in eye size and a marked bleaching in the middle of the eye.

(Eissenberg et al., 2011)

rb¹ is a complex modifier of the eye phenotype caused by expression of bchs^EP2299 under the control of Scer\GAL4^GMR.PF.

g¹ is a complex modifier of the eye phenotype caused by expression of bchs^EP2299 under the control of Scer\GAL4^GMR.PF.

cm¹ is a complex modifier of the eye phenotype caused by expression of bchs^EP2299 under the control of Scer\GAL4^GMR.PF.

(Simonsen et al., 2007)

Flies that are mutant for Df(3R)e-R1 show a strong enhancement of the Scer\GAL4^GMR.PF>bchs^EP2299 overexpression phenotype.

Rab11 heterozygotes act as dominant enhancers of the Scer\GAL4^GMR.PF>bchs^EP2299 eye phenotype, resulting in adults with severely reduced eyes. The following alleles cause this enhancement: Rab11^j2D1, Rab11^93Bi, Rab11^ex1, Rab11^ex2, Rab11^ETo11, and Rab11^ETo3.

(Khodosh et al., 2006)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

9887

y¹ w^*; P{EP}EP2299, bchs⁵⁸/CyO

9888

y¹ w^*; P{EP}EP2299, bchs¹⁷/CyO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

Beach1^EP2299

(Kraut et al., 2001, Kraut et al., 2001)

EP(2)2299

(Filimonenko et al., 2010, Abdelilah-Seyfried et al., 2001, Abdelilah-Seyfried et al., 2000)

EP2299^EP2299

bchs⁴

(Simonsen et al., 2007, Finley et al., 2003)

bchs⁴EP(2)2299

(Finley et al., 2003)

bchs^EP2299

(Kriston-Vizi et al., 2011)

Name Synonyms

Secondary FlyBase IDs

References (17)

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