FB2025_01 , released February 20, 2025
Allele: Dmel\EP2146aEP2146a
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General Information
Symbol
Dmel\EP2146aEP2146a
Species
D. melanogaster
Name
FlyBase ID
FBal0119645
Feature type
allele
Associated gene
EP2146a
Associated Insertion(s)
P{EP}EP2146aEP2146a
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Pena-Rangel et al., 2002, Abdelilah-Seyfried et al., 2000)
Progenitor genotype
Associated Insertion(s)
P{EP}EP2146aEP2146a
Cytology
Description

P{EP} insertion.

(Abdelilah-Seyfried et al., 2000)
Allele components
Component
Use(s)
Inserted element
P{EP}
Regulatory region(s)
UAS
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression via Scer\GAL4fkh.PH results in a strongly penetrant 'searching cells' phenotype in the embryonic salivary gland.

      (Maybeck and Röper, 2009)

      Expression of EP2146aEP2146a under the control of Scer\GAL4sca-537.4 results in the loss of external support cells of several scutellar macrochaetae without loss of the sheath cell. Sensory organs with one socket and two shafts, and no socket, one shaft and one sheath cell are seen.

      (Abdelilah-Seyfried et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhanced by
      Statement
      Reference

      EP2146aEP2146a, Scer\GAL4sca-537.4 has visible phenotype, non-enhanceable by N55e11

      (Abdelilah-Seyfried et al., 2000)
      NOT suppressed by
      Statement
      Reference

      EP2146aEP2146a, Scer\GAL4sca-537.4 has visible phenotype, non-suppressible by N55e11

      (Abdelilah-Seyfried et al., 2000)
      Enhancer of
      Statement
      Reference

      Scer\GAL4pnr-MD237/EP2146aEP2146a is an enhancer of visible phenotype of pnrMD237

      (Pena-Rangel et al., 2002)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Scer\GAL4pnr-MD237/EP2146aEP2146a is an enhancer of adult thorax phenotype of pnrMD237

      (Pena-Rangel et al., 2002)
      NOT Enhancer of
      Statement
      Reference

      Scer\GAL4sca-537.4/EP2146aEP2146a is a non-enhancer of phenotype of N55e11

      (Abdelilah-Seyfried et al., 2000)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      pnrMD237/+ adults expressing EP2146aEP2146a under the control of Scer\GAL4pnr-MD237 have a slight thoracic cleft.

      (Pena-Rangel et al., 2002)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Separable from: UbcD2EP2146b.

      (Abdelilah-Seyfried et al., 2000)

      Selected as: a P{EP} insertion line that modifies the pnrMD237/+ phenotype when expressed using Scer\GAL4pnr-MD237.

      (Pena-Rangel et al., 2002)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      EP(2)2146a
      (Abdelilah-Seyfried et al., 2001, Abdelilah-Seyfried et al., 2000)
      EP2146aEP2146a
      Name Synonyms
      Secondary FlyBase IDs
        References (4)