FlyBase Allele Report: Dmel\MESR4[EP988]

General Information

Symbol

Dmel\MESR4^EP988

Species

D. melanogaster

Name

FlyBase ID

FBal0119659

Feature type

allele

Associated gene

Dmel\MESR4

Associated Insertion(s)

P{EP}MESR4^EP988

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Pena-Rangel et al., 2002, Gene Disruption Project members, 2001-, Abdelilah-Seyfried et al., 2000)

Progenitor genotype

Associated Insertion(s)

P{EP}MESR4^EP988

Cytology

Description

P{EP} insertion.

(Abdelilah-Seyfried et al., 2000)

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:17,548,234..17,548,234 [+]

(Zhu et al., 2005, Pena-Rangel et al., 2002, Gene Disruption Project members, 2001-, Abdelilah-Seyfried et al., 2000)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

partially lethal - majority die, with Scer\GAL4^ap-md544

(Pena-Rangel et al., 2002)

visible, with Scer\GAL4^sca-537.4

(Abdelilah-Seyfried et al., 2000)

Phenotype Manifest In

adult abdomen & macrochaeta, with Scer\GAL4^sca-537.4

(Abdelilah-Seyfried et al., 2000)

dorsocentral bristle, with Scer\GAL4^sca-537.4

(Abdelilah-Seyfried et al., 2000)

scutellar bristle, with Scer\GAL4^sca-537.4

(Abdelilah-Seyfried et al., 2000)

trichogen cell, with Scer\GAL4^sca-537.4

(Abdelilah-Seyfried et al., 2000)

wing, with Scer\GAL4^ap-md544

(Pena-Rangel et al., 2002)

Detailed Description

Statement

Reference

Flies expressing MESR4^EP988 under the control of Scer\GAL4^ap-md544 have deformed wings.

(Pena-Rangel et al., 2002)

Expression of MESR4^EP988 under the control of Scer\GAL4^sca-537.4 results in potential shaft-to-socket transformations on the abdomen and the loss of several scutellar and dorsocentral macrochaetae. Shafts with branched tips or dot-like shaft morphology are seen.

(Abdelilah-Seyfried et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

MESR4^EP988, Scer\GAL4^sca-537.4 has visible phenotype, non-enhanceable by H[+]/H^E21

(Abdelilah-Seyfried et al., 2000)

NOT suppressed by

Statement

Reference

MESR4^EP988, Scer\GAL4^sca-537.4 has visible phenotype, non-suppressible by H[+]/H^E21

(Abdelilah-Seyfried et al., 2000)

Enhancer of

Statement

Reference

MESR4^EP988/Scer\GAL4^pnr-MD237 is an enhancer of visible phenotype of pnr^MD237

(Pena-Rangel et al., 2002)

NOT Enhancer of

Statement

Reference

MESR4^EP988, Scer\GAL4^GMR.PF is a non-enhancer of visible phenotype of Rac1^N17.UAS, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

MESR4^EP988, Scer\GAL4^GMR.PF is a non-enhancer of visible phenotype of Cdc42^L89.UAS, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

MESR4^EP988, Scer\GAL4^GMR.PF is a non-enhancer of visible phenotype of Scer\GAL4^GMR.PF, btl::Egfr^λ.UAS

(Zhu et al., 2005)

Suppressor of

Statement

Reference

MESR4^EP988, Scer\GAL4^GMR.PF is a suppressor | partially of visible phenotype of Scer\GAL4^GMR.PF, btl^λ.UAS, stumps^UAS.Tag:FLAG

(Zhu et al., 2005)

MESR4^EP988, Scer\GAL4^GMR.PF is a suppressor of visible phenotype of Pvr^λ.UAS, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

NOT Suppressor of

Statement

Reference

MESR4^EP988, Scer\GAL4^GMR.PF is a non-suppressor of visible phenotype of Rac1^N17.UAS, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

MESR4^EP988, Scer\GAL4^GMR.PF is a non-suppressor of visible phenotype of Cdc42^L89.UAS, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

MESR4^EP988, Scer\GAL4^GMR.PF is a non-suppressor of visible phenotype of Scer\GAL4^GMR.PF, btl::Egfr^λ.UAS

(Zhu et al., 2005)

Phenotype Manifest In

Enhancer of

Statement

Reference

MESR4^EP988/Scer\GAL4^pnr-MD237 is an enhancer of adult thorax phenotype of pnr^MD237

(Pena-Rangel et al., 2002)

MESR4^EP988/Scer\GAL4^pnr-MD237 is an enhancer of chaeta phenotype of pnr^MD237

(Pena-Rangel et al., 2002)

NOT Enhancer of

Statement

Reference

MESR4^EP988, Scer\GAL4^GMR.PF is a non-enhancer of eye phenotype of Scer\GAL4^GMR.PF, btl::Egfr^λ.UAS

(Zhu et al., 2005)

MESR4^EP988/Scer\GAL4^sca-537.4 is a non-enhancer of phenotype of H^E21

(Abdelilah-Seyfried et al., 2000)

Suppressor of

Statement

Reference

MESR4^EP988, Scer\GAL4^GMR.PF is a suppressor | partially of eye phenotype of Scer\GAL4^GMR.PF, btl^λ.UAS, stumps^UAS.Tag:FLAG

(Zhu et al., 2005)

MESR4^EP988, Scer\GAL4^GMR.PF is a suppressor of eye phenotype of Pvr^λ.UAS, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

NOT Suppressor of

Statement

Reference

MESR4^EP988, Scer\GAL4^GMR.PF is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PF, btl::Egfr^λ.UAS

(Zhu et al., 2005)

MESR4^EP988/Scer\GAL4^sca-537.4 is a non-suppressor of phenotype of H^E21

(Abdelilah-Seyfried et al., 2000)

Other

Statement

Reference

MESR4^EP988, Scer\GAL4^pnr-MD237, pnr^MD237/pnr[+] has macrochaeta phenotype

(Pena-Rangel et al., 2002)

MESR4^EP988, Scer\GAL4^pnr-MD237, pnr^MD237/pnr[+] has scutellum phenotype

(Pena-Rangel et al., 2002)

MESR4^EP988, Scer\GAL4^pnr-MD237, pnr^MD237 has macrochaeta phenotype

(Pena-Rangel et al., 2002)

MESR4^EP988, Scer\GAL4^pnr-MD237, pnr^MD237 has scutellum phenotype

(Pena-Rangel et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

pnr^MD237/+ adults expressing MESR4^EP988 under the control of Scer\GAL4^pnr-MD237 have a slight thoracic cleft, a reduced scutellum and loss of several macrochaetae.

(Pena-Rangel et al., 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Selected as: a P{EP} insertion line that modifies the pnr^MD237/+ phenotype when expressed using Scer\GAL4^pnr-MD237.

(Pena-Rangel et al., 2002)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

EP(2)0988

(Abdelilah-Seyfried et al., 2000)

EP0988^EP0988

EP988^EP988

MESR4^EP988

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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