FB2025_01 , released February 20, 2025
Allele: Dmel\Cdk4UAS.Tag:MYC
Open Close
General Information
Symbol
Dmel\Cdk4UAS.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0119685
Feature type
allele
Associated gene
Dmel\Cdk4
Associated Insertion(s)
Carried in Construct
P{UAS-Cdk4-myc}
Key Links
Transgenic product class
wild_type
(Meyer et al., 2000)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Meyer et al., 2000)
Mutagen
in vitro construct
(Meyer et al., 2000)
Progenitor genotype
Carried in construct
P{UAS-Cdk4-myc}
Cytology
Description

UASt sequences drive expression of Cdk4 tagged with six epitope copies of the Tag:MYC tag at the C terminus.

(Meyer et al., 2000)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Cdk4
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Other
      Statement
      Reference

      Cdk4UAS.Tag:MYC, CycDUAS.cDa, Scer\GAL4GMR.PF has eye disc & photoreceptor cell phenotype

      (Chen et al., 2003)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of CycDScer\UAS.cDa with Cdk4Scer\UAS.T:Hsap\MYC driven by Scer\GAL4GMR.PF blocks photoreceptor differentiation in the third instar eye disc. This effect is suppressed by upd1Scer\UAS.cCa. The eye and eye disc overgrowth phenotypes seen in upd1Scer\UAS.cCa; Scer\GAL4GMR.PF flies, are dramatically enhanced by CycDScer\UAS.cDa with Cdk4Scer\UAS.T:Hsap\MYC : All ommatidia are dramatically enlarged in these eyes, and the entire eye bulges out of the head. The increase in ommatidial numbers seen in upd1Scer\UAS.cCa; Scer\GAL4GMR.PF eye discs is also enhanced.

      (Chen et al., 2003)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Cdk4Scer\UAS.T:Hsap\MYC
      Cdk4UAS.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (2)