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General Information
Symbol
Dmel\vnEPg35521
Species
D. melanogaster
Name
FlyBase ID
FBal0120291
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

P{EPg} insertion in the 5' untranslated region. The P{EPg} element is inserted such that expression from the Scer\UAS sequences in the P{EPg} element drives expression of vn.

Insertion components
P{EPg}vnEPg35521
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Border cells in the ovaries of vnEPg35521; Scer\GAL4slbo.2.6 animals form significantly fewer long cellular extensions (20-40 μm) and intermediate cellular extensions (10-20 μm).

Border cell migration is affected when vnEPg35521 is expressed under the control of either Scer\GAL4slbo.2.6 or Scer\GAL4nos.UTR.T:Hsim\VP16 or both Scer\GAL4slbo.2.6 and Scer\GAL4nos.UTR.T:Hsim\VP16.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressed by
Enhancer of
NOT Enhancer of
Other
Additional Comments
Genetic Interactions
Statement
Reference

Co-expression of vnEPg35521 and EgfrScer\UAS.T:Avic\GFP under the control of Scer\GAL4slbo.2.6 results in strong defects in border cell migration, with no migration being seen in approximately 80% of stage 10 egg chambers.

The addition of PvrScer\UAS.cDa suppresses the effect of vnEPg35521 (driven by Scer\GAL4slbo.2.6). The addition of vnEPg35521 to PvrDN.Scer\UAS (driven by Scer\GAL4slbo.2.6) leads to a strong enhancement of the migration defect.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
vnEPg35521
Name Synonyms
Secondary FlyBase IDs
    References (4)