FB2025_01 , released February 20, 2025
Allele: Dmel\tefZ3455
Open Close
General Information
Symbol
Dmel\tefZ3455
Species
D. melanogaster
Name
FlyBase ID
FBal0120312
Feature type
allele
Associated gene
Dmel\tef
Associated Insertion(s)
Carried in Construct
Also Known As
tefZ2-3455
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Arya et al., 2006, Wakimoto et al., 2004, Tomkiel et al., 2001)
Progenitor genotype
Cytology
Description

Nucleotide substitution: C376G.

(Arya et al., 2006)

Amino acid replacement: Q126term.

(Arya et al., 2006)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:17,056,293..17,056,293 [-]
Nucleotide change:

C17056293T

Reported nucleotide change:

C376G

Amino acid change:

Q126term | tef-PA

Reported amino acid change:

Q126term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. Curator note: The reported nucleotide position (C376G) of the mutation should have been C376T.

(Arya et al., 2006)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous males are fertile, but their progeny show paternal chromosome loss (loss rate of paternal chromosome 4 is 27%). The timing of the chromosome loss is meiotic.

      (Wakimoto et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      tefZ2-3455
      (Weber et al., 2020, Blattner et al., 2016)
      tefZ3455
      (Arya et al., 2006)
      tefz2-3455
      (Kabakci et al., 2022)
      tefz3455
      Name Synonyms
      Secondary FlyBase IDs
        References (6)