Allele Dmel\slp1^Scer\UAS.cSa

General Information
Symbol	Dmel\slp1^Scer\UAS.cSa	Species	D. melanogaster
Name	Saccharomyces cerevisiae UAS construct a of Struhl	FlyBase ID	FBal0120334
Feature type	allele	Associated gene	Dmel\slp1

Allele class
Mutagen	FLPase
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	FLPase (Struhl, 2001.2.5)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	slp1^{Scer\FRT.Rnor\CD2.Scer\UAS} (Struhl, 2001.2.5)
Nature of the lesion	Statement Reference Scer\FRT-Rnor\CD2^A902 cassette has been excised, juxtaposing Scer\UAS regulatory sequences with slp1 coding sequences. (Struhl, 2001.2.5)
Carried in construct	P{Scer\UAS(-FRT)slp1.S} (Gebelein et al., 2004, Sato and Tomlinson, 2007, Struhl, 2001.2.5, Lee and Frasch, 2000, Buescher et al., 2004, Reim et al., 2012)
Cytology
Phenotypic Data
Phenotypic Class
	cell migration defective \| embryonic stage 12, with Scer\GAL4^twi.PG (Reim et al., 2012) cell migration defective \| embryonic stage 13, with Scer\GAL4^twi.PG (Reim et al., 2012)
Phenotype Manifest In
	longitudinal visceral muscle primordium \| embryonic stage 12, with Scer\GAL4^twi.PG (Reim et al., 2012) visceral mesoderm, with Scer\GAL4^how-24B, Scer\GAL4^twi.PG (Lee and Frasch, 2000)
Detailed Description
	Statement Reference In embryos expressing slp1[Scer\UAS.cSa] under the control of Scer\GAL4[twi.PG] LVM founder cell migration initiates similarly to the wild type, but the tracks become progressively irregular during germ band retraction at stage 12. By the end of germ band retraction none of the cells have reached the anterior of the trunk visceral mesoderm (TVM) compared to wild type. (Reim et al., 2012) When expression is driven by Scer\GAL4^twi.PG and Scer\GAL4^how-24B the trunk visceral mesoderm is strongly reduced. (Lee and Frasch, 2000)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
NOT Suppressor of
Statement Reference Scer\GAL4^twi.PG/slp1^Scer\UAS.cSa is a non-suppressor of embryonic/larval dorsal vessel & embryonic myoblast phenotype of wg^l-17 (Lee and Frasch, 2000) Scer\GAL4^twi.PG/slp1^Scer\UAS.cSa is a non-suppressor of embryonic/larval somatic muscle & embryonic myoblast \| dorsal phenotype of wg^l-17 (Lee and Frasch, 2000)
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer	G. Struhl

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	slp1^Scer\UAS.cSa
Name Synonym	Saccharomyces cerevisiae UAS construct a of Struhl (Struhl, 2001.2.5)
Secondary FlyBase IDs

References ( 6 )
Research paper	Reim et al., 2012, Dev. Biol. 368(1): 28--43 The FGF8-related signals Pyramus and Thisbe promote pathfinding, substrate adhesion, and survival of migrating longitudinal gut muscle founder cells. [FBrf0218673] Sato and Tomlinson, 2007, Development 134(4): 659--667 Dorsal-ventral midline signaling in the developing Drosophila eye. [FBrf0195057] Buescher et al., 2004, Curr. Biol. 14(19): 1694--1702 Drosophila T box proteins break the symmetry of hedgehog-dependent activation of wingless. [FBrf0180065] Gebelein et al., 2004, Nature 431(7009): 653--659 Direct integration of Hox and segmentation gene inputs during Drosophila development. [FBrf0179749] Lee and Frasch, 2000, Development 127(24): 5497--5508 Wingless effects mesoderm patterning and ectoderm segmentation events via induction of its downstream target sloppy paired. [FBrf0131347]
Personal communication to FlyBase	Struhl, 2001.2.5, Helping FlyBase: UAS-slp1. Helping FlyBase: UAS-slp1. [FBrf0133298]

Allele Dmel\slp1Scer\UAS.cSa

Allele Dmel\slp1^Scer\UAS.cSa