Allele Dmel\cos^{Scer\UAS.T:Ivir\HA1}

General Information
Symbol	Dmel\cos^{Scer\UAS.T:Ivir\HA1}	Species	D. melanogaster
Name		FlyBase ID	FBal0120526
Feature type	allele	Associated gene	Dmel\cos

Allele class
Mutagen	in vitro construct - coding region fusion, in vitro construct - regulatory fusion
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - coding region fusion (Wang et al., 2000) in vitro construct - regulatory fusion (Wang et al., 2000)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Construct: Scer\UAS sequences drive expression of the full length cos coding sequence tagged with a double T:Ivir\HA1 tag. (Wang et al., 2000)
Carried in construct	P{UAS-Cos2.W} (Liu et al., 2007, Jia et al., 2002, Jia et al., 2003, Zhang et al., 2005, Wang et al., 2000)
Tagged with	T:Ivir\HA1 (Wang et al., 2000, Jia et al., 2002, Jia et al., 2003)
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In

Detailed Description
	Statement Reference
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

Comments
	Carried in a plasmid and transfected into cl-8 cells. (Wang et al., 2000)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	cos^{Scer\UAS.T:Ivir\HA1}
Name Synonym
Secondary FlyBase IDs

References ( 5 )
Research paper	Liu et al., 2007, Genes Dev. 21(15): 1949--1963 Fused-Costal2 protein complex regulates Hedgehog-induced Smo phosphorylation and cell-surface accumulation. [FBrf0202173] Zhang et al., 2005, Dev. Cell 8(2): 267--278 Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus. [FBrf0183877] Jia et al., 2003, Genes Dev. 17(21): 2709--2720 Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail. [FBrf0167606] Jia et al., 2002, Nature 416(6880): 548--552 Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus. [FBrf0149689] Wang et al., 2000, Genes Dev. 14(22): 2893--2905 Interactions with costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus. [FBrf0132069]

Allele Dmel\cosScer\UAS.T:Ivir\HA1

Allele Dmel\cos^{Scer\UAS.T:Ivir\HA1}