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General Information
Symbol
Dmel\bab2Ar07
Species
D. melanogaster
Name
FlyBase ID
FBal0120551
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
babAR07
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference
    Caused by aberration
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    Homozygous bab2Ar07 mutant adults display shortened tarsi with segmental joint fusions, particularly the fully penetrant fusion of ts4-5.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Phenotype Manifest In
    Other
    Statement
    Reference

    bab1Ar07, bab2Ar07 has tarsal segment & joint phenotype

    bab1Ar07, bab2Ar07 has antennal segment & joint phenotype

    bab1Ar07, bab2Ar07 has adult cuticle & abdominal segment 7 phenotype

    bab1Ar07, bab2Ar07 has abdominal tergite 7 & trichome | female phenotype

    bab1Ar07, bab2Ar07 has abdominal sternite 7 & trichome | female phenotype

    bab1Ar07, bab2Ar07 has abdominal sternite 6 & macrochaeta | female phenotype

    bab1Ar07, bab2Ar07 has abdominal sternite 7 & macrochaeta | female phenotype

    bab1Ar07, bab2Ar07/bab2[+] has adult cuticle & abdominal segment 5 | female phenotype

    bab1Ar07, bab2Ar07 has adult cuticle & abdominal segment 6 | female phenotype

    bab1Ar07/bab1[+], bab2Ar07 has adult cuticle & abdominal segment 5 | female phenotype

    bab1Ar07, bab2Ar07 has adult cuticle & abdominal segment 2 phenotype

    bab1Ar07, bab2Ar07 has adult cuticle & abdominal segment 3 phenotype

    bab1Ar07, bab2Ar07 has adult cuticle & abdominal segment 4 phenotype

    bab1Ar07, bab2Ar07 has adult cuticle & abdominal segment 5 phenotype

    bab1Ar07, bab2Ar07 has adult cuticle & abdominal segment 6 phenotype

    Additional Comments
    Genetic Interactions
    Statement
    Reference

    bab2E4/Df(3L)babAr07 flies have ectopic sex combs on tarsal segment 2 (7-8 bristles) and tarsal segment 3 (3-4 bristles) and show fusion of tarsal segments 4 and 5. Expression of bab1Scer\UAS.cGa under the control of Scer\GAL4bab1-Pgal4-2 partially rescues the mutant leg phenotypes of bab2E4/Df(3L)babAr07 flies; there is no sex comb on tarsal segment 3, tarsal segments 4 and 5 are separated by a well-defined joint but there is a small sex comb on tarsal segment 2 (1-2 bristles). Expression of bab24.Scer\UAS under the control of Scer\GAL4bab1-Pgal4-2 fully rescues the mutant leg phenotypes of bab2E4/Df(3L)babAr07 flies; tarsal segments 2 and 3 do not have any sex combs and tarsal segments 4 and 5 are always properly separated. bab2E4/Df(3L)babAr07 females have ovaries of reduced size which contain only a few follicles with abnormal orientation. They are subfertile and lay very few eggs. These defects are partially rescued by bab1Scer\UAS.cGa expressed under the control of Scer\GAL4bab1-Pgal4-2 and are fully rescued by bab24.Scer\UAS expressed under the control of Scer\GAL4bab1-Pgal4-2. bab2E4/Df(3L)babAr07 females show increased abdominal pigmentation; segments A5 and A6 are fully pigmented. This defect is not rescued by bab24.Scer\UAS expressed under the control of Scer\GAL4bab1-Pgal4-2.

    Tarsal joints are fused or absent in Df(3L)babAr07/Df(3L)babAr07 animals and the a4/a5 and a5/arista joints are missing.

    Homozygous Df(3L)babAr07 females have a very strong mutant ovary phenotype; the ovaries are very small and no developing follicles are seen. Df(3L)babAr07 homozygotes have a very strong mutant leg phenotype.

    Df(3L)babAr07/+ females shows male-specific pigmentation of A5 and A6. Df(3L)babAr07/Df(3L)babAr07 males and females show ectopic pigmentation in A2-A7 tergites, A4-A7 sternites and occasionally in the A1 tergite. Df(3L)babAr07/Df(3L)babAr07 females expression of posterior morphological characters is increased: trichomes are absent from A7 tergite and sternite and the number of bristles on A6 and A7 sternites is reduced. A6 sternite bears some resemblance to the A6 sternite of males or the A7 sternite of females. The thorn bristles normally present in A8 are replaced by wavy bristles typical of the male A9 genital arch. The ectopic male pigmentation seen in Df(3L)babAr07/+ females is suppressed by Df(3R)Ubx-RS4-8/+.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Not rescued by
    Comments

    A single copy of bab2+tBAC26B15 rescues the leg segmentation phenotype seen in bab2Ar07 mutant flies.

    A single copy of bab2BAC26B15.ΔLAE fails to rescue the leg segmentation phenotype seen in bab2Ar07 mutant flies.

    Expression of bab2+mLAE rescues the leg segmentation phenotype seen in bab2Ar07 mutant flies.

    Images (0)
    Mutant
    Wild-type
    Stocks (1)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (5)
    Reported As
    Symbol Synonym
    Name Synonyms
    Secondary FlyBase IDs
      References (7)