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General Information
Symbol
Dmel\TorEP2353
Species
D. melanogaster
Name
FlyBase ID
FBal0120582
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

The P{EP} insertion is located 262bp upstream of the putative translation start of Tor, and within the 5' UTR.

The P{EP} insertion is located 74bp downstream of the transcription start site.

Insertion components
P{EP}TorEP2353
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Mutant larvae expressing TorEP2353 under the control of Scer\GAL4elav-C155 have reduced or abnormal synapses. Mutant larvae expressing TorEP2353 under the control of Scer\GAL4elav-C155 have ISN neuron pathfinding defects.

Homozygotes hatch at normal rates, but grow more slowly than normal and eventually arrest during larval development, reaching only 79% the mass of wild-type controls. The mutants remain viable and active during an extended larval period of about 30 days and eventually die without pupating.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
NOT Suppressor of
Statement
Reference

Tor[+], TorEP2353, Scer\GAL4[-] is a non-suppressor of lethal | larval stage phenotype of gig193/gig109

Phenotype Manifest In
Suppressor of
Statement
Reference

TorEP2353/Scer\GAL4[-] is a suppressor of adult head phenotype of Pten117

Additional Comments
Genetic Interactions
Statement
Reference

PtenMGH1/TorEP2353 somatic clones show a slight decrease in size compared to wild-type. TorEP2353/Tork17004, S6kScer\UAS.cWa flies are slightly smaller than wild-type, but are fertile and develop at a similar rate to wild-type flies.

Xenogenetic Interactions
Statement
Reference

Hsap\RPS6KB1D4.Scer\UAS (driven by Scer\GAL4Act5C.PP) rescues TorEP2353/TorEP2353 or TorEP2353/Tork17004 animals to viability.

Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
TorEP2353
Name Synonyms
Secondary FlyBase IDs
    References (6)