P2293L | Tor-PA; P2294L | Tor-PB
Position of mutation on reference sequence inferred by FlyBase curator. Difference between annotated and reported sites of amino acid substitution due to authors reported CDS being 10aa longer.
Around 60% of Tor2L1/+; gig109/gig193 flies survive to adulthood, while no gig109/gig193 survive to the pupal stage. The Tor+t9.4 transgene reduces the amount of Tor2L1/+; gig109/gig193 flies that survive to the pupal stage from around 85% to around 65%.
The large size and disorganisation of ommatidia in Scer\GAL4GMR.PF/+; RhebEP50.084/+ flies is partially dominantly suppressed by Tor2L1 (ommatidia are 1.27 times wild-type size, and slightly disorganised).
The first instar larval lethality due to Tsc129 is partially suppressed by heterozygosity for Tor2L1 : 31% (n = 193) of Tor2L1/+ Tsc129/Tsc129 animals survive to the pupal stage. The increased cell size seen in somatic clones of Tsc129 in the eye is partially suppressed in a Tor2L1 heterozygous background: the resulting clone cells are 1.3X wild-type size, compared to 1.9X for Tsc129 somatic clone cells in a wild-type background. Cells in Tor2L1; Tsc129 double mutant somatic clones are approximately 0.25 times the size of their heterozygous neighbours - i.e.- have little or no size difference with Tor2L1 somatic clone cells.
The second instar lethality of homozygous Tsc1Q87X is rescued to adulthood (18.5%) or pupal stages (82.5%) by heterozygosity for Tor2L1. The second instar lethality of homozygous Tsc1Q87X is rescued to adulthood (62%) or pupal stages (93%) by heterozygosity for both S6kl-1 and Tor2L1. The rescued animals are slightly larger than wild-type flies, with overall patterning appearing normal. The rescued females are semi-fertile when crossed to wild-type males, whereas the rescued males are fully fertile when crossed to wild-type females.