FlyBase Allele Report: Dmel\mTor[+t9.4]

General Information

Symbol

Dmel\mTor^+t9.4

Species

D. melanogaster

Name

FlyBase ID

FBal0120585

Feature type

allele

Associated gene

Dmel\mTor

Associated Insertion(s)

Carried in Construct

P{dTOR-9.4}

Key Links

Transgenic product class

genomic_DNA

(Zhang et al., 2000)

wild_type

(Zhang et al., 2000)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

genomic_DNA

(Zhang et al., 2000)

wild_type

(Zhang et al., 2000)

Mutagen

in vitro construct

(Zhang et al., 2000)

Progenitor genotype

Carried in construct

P{dTOR-9.4}

Cytology

Description

Contains a 9.4 kb genomic fragment including the Tor coding region and 1.1kb of upstream sequence.

(Zhang et al., 2000)

Allele components

Component

Use(s)

Regulatory region(s)

mTor

Encoded product / tool

mTor

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

wild-type

(Zhang et al., 2000)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

gig¹⁹³/gig¹⁰⁹, mTor^+t9.4 has lethal | larval stage phenotype, suppressible | partially by mTor^2L1/Tor[+]

(Zhang et al., 2006)

NOT suppressed by

Statement

Reference

gig¹⁹³/gig¹⁰⁹, mTor^+t9.4 has lethal | larval stage phenotype, non-suppressible by Tor[+]/mTor^ΔP

(Zhang et al., 2006)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Around 60% of gig¹⁰⁹/gig¹⁹³; Tor^ΔP/+ flies survive to the pupal, but not the adult stage. However, one copy of the Tor^+t9.4 transgene blocks the ability of Tor^ΔP/+ to rescue gig¹⁰⁹/gig¹⁹³ flies to pupal viability. The Tor^+t9.4 transgene reduces the amount of Tor^2L1/+; gig¹⁰⁹/gig¹⁹³ flies that survive to the pupal stage from around 85% to around 65%.