FlyBase Allele Report: Dmel\mTor[ΔP]

General Information

Symbol

Dmel\mTor^ΔP

Species

D. melanogaster

Name

FlyBase ID

FBal0120586

Feature type

allele

Associated gene

Dmel\mTor

Associated Insertion(s)

Carried in Construct

Also Known As

TOR^ΔP, Tor^DeltaP, dTor^ΔP

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Zhang et al., 2000)

Progenitor genotype

mTor^EP2353

(Zhang et al., 2000)

Cytology

Description

Contains a deletion originating from the P{EP}Tor^EP2353 that extends 3514 bp downstream, removing the Tor translation start site and the amino terminal 902 codons.

(Zhang et al., 2000)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

2L:13,004,524..13,008,038 [+]

Comment:

Mutation is a deletion resulting from imprecise excision of Tor^EP2353.

(Zhang et al., 2000)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Parkinson's disease

modeled by Lrrk^UAS.cIa

(Penney et al., 2016)

ameliorates viral infectious disease

modeled by EBV\BRLF1^GMR.PA

(Adamson et al., 2014, Adamson and Lajeunesse, 2012)

exacerbates viral infectious disease

modeled by EBV\BZLF1^GMR.PA

(Adamson et al., 2014, Adamson and Lajeunesse, 2012)

ameliorates infectious mononucleosis

modeled by EBV\BRLF1^GMR.PA

(Adamson et al., 2014, Adamson and Lajeunesse, 2012)

exacerbates infectious mononucleosis

modeled by EBV\BZLF1^GMR.PA

(Adamson et al., 2014, Adamson and Lajeunesse, 2012)

ameliorates Epstein-Barr virus hepatitis

modeled by EBV\BRLF1^GMR.PA

(Adamson et al., 2014, Adamson and Lajeunesse, 2012)

exacerbates Epstein-Barr virus hepatitis

modeled by EBV\BZLF1^GMR.PA

(Adamson et al., 2014, Adamson and Lajeunesse, 2012)

ameliorates kidney cancer

modeled by Ras85D^V12.UAS

(Zeng et al., 2010)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

FlyBase_internaltransgene_features:cell lethal:cell lethal | somatic clone

(David-Morrison et al., 2016)

abnormal body size | adult stage

(Wu et al., 2015)

abnormal cell cycle | germline clone

(Wei et al., 2014)

abnormal cell size

(Scott et al., 2004)

abnormal developmental rate

(David-Morrison et al., 2016, Scott et al., 2004, Zhang et al., 2000)

abnormal mitotic cell cycle | somatic clone

(Saucedo et al., 2003)

abnormal neuroanatomy | adult stage | somatic clone

(Luo et al., 2020)

abnormal neuroanatomy | larval stage

(Lin et al., 2015)

abnormal neuroanatomy | somatic clone

(Yaniv et al., 2012, Koike-Kumagai et al., 2009)

abnormal neurophysiology | adult stage | somatic clone

(David-Morrison et al., 2016)

abnormal neurophysiology | larval stage (with mTor^E161K)

(Penney et al., 2012)

decreased body size

(Zhang et al., 2000)

decreased cell number | larval stage | progressive | somatic clone

(Zhang et al., 2000)

decreased cell number | somatic clone

(Zhang et al., 2000)

decreased cell number | somatic clone - Minute background | third instar larval stage

(Devilliers et al., 2021)

decreased cell size | adult stage | somatic clone

(Zhang et al., 2000)

decreased cell size | larval stage | somatic clone

(Zhang et al., 2000)

decreased cell size | somatic clone

(David-Morrison et al., 2016, Scott et al., 2007, Saucedo et al., 2003, Zhang et al., 2000)

decreased cell size | somatic clone - Minute background | third instar larval stage

(Devilliers et al., 2021)

decreased occurrence of cell division | somatic clone | third instar larval stage

(Kim et al., 2017)

decreased size | larval stage (with mTor^E161K)

(Penney et al., 2012)

lethal (with mTor^A948V)

(Zhang et al., 2006)

lethal (with mTor^E161K)

(Zhang et al., 2006)

lethal (with mTor^G2256D)

(Zhang et al., 2006)

lethal (with mTor^Q528stop)

(Zhang et al., 2006)

lethal (with mTor^R97C)

(Zhang et al., 2006)

lethal (with mTor^R248stop)

(Zhang et al., 2006)

lethal (with mTor^V2148D)

(Zhang et al., 2006)

lethal (with mTor^W1251R)

(Zhang et al., 2006)

lethal - all die before end of larval stage

(Scott et al., 2004)

some die during larval stage

(Scott et al., 2004)

visible | adult stage

(Wu et al., 2015)

visible | adult stage | somatic clone

(David-Morrison et al., 2016)

Phenotype Manifest In

axon | somatic clone

(Yaniv et al., 2012)

cell cycle

(Zhang et al., 2000)

dendrite | adult stage | somatic clone

(Luo et al., 2020)

dendrite | somatic clone

(Yaniv et al., 2012, Koike-Kumagai et al., 2009)

dendritic arborizing neuron | somatic clone

(Koike-Kumagai et al., 2009)

distal medullary amacrine neuron Dm8 | adult stage | somatic clone

(Luo et al., 2020)

dorsal mesothoracic disc & nucleolus

(Zhang et al., 2000)

egg chamber | germline clone

(Wei et al., 2014)

embryonic/larval fat body

(Zhang et al., 2000)

embryonic/larval neuromuscular junction | larval stage (with mTor^E161K)

(Penney et al., 2012)

embryonic/larval salivary gland

(Zhang et al., 2000)

eye | adult stage | somatic clone

(David-Morrison et al., 2016)

eye disc | somatic clone

(Juhász et al., 2008)

eye disc | somatic clone | third instar larval stage

(Kim et al., 2017)

eye photoreceptor cell | adult stage | somatic clone

(David-Morrison et al., 2016)

fat body

(Scott et al., 2004)

fat body | somatic clone

(Scott et al., 2007)

follicle cell | somatic clone

(David-Morrison et al., 2016)

larva

(Zhang et al., 2000)

larval fat cell | somatic clone - Minute background | third instar larval stage

(Devilliers et al., 2021)

larval multidendritic class IV neuron

(Lin et al., 2015)

larval somatic muscle (with mTor^E161K)

(Penney et al., 2012)

salivary gland imaginal ring

(Zhang et al., 2000)

wing | adult stage | somatic clone

(Zhang et al., 2000)

wing blade

(Wu et al., 2015)

Detailed Description

Statement

Reference

Tor^ΔP/Tor^ΔP fat body clones in a Minute background, induced during embryogenesis and analyzed at early third instar larval stage, are small and bear smaller cells than controls.

(Devilliers et al., 2021)

Tor^ΔP homozygous somatic clones in third instar larval eye discs exhibit a delay in G1/S transition during the second mitotic wave, as mutant cells enter S phase in a more posterior region than control cells.

(Kim et al., 2017)

Electroretinograms (ERGs) recorded from Tor^ΔP/Tor^ΔP full eye clones show significantly reduced amplitudes and off transients compared to controls. Tor^ΔP/Tor^ΔP full eye clones are reduced in size compared to controls. Tor^ΔP/Tor^ΔP mutants exhibit slow growth and developmental delay. Tor^ΔP/Tor^ΔP mutants in egg chamber follicle cells show reduced clone and cell size.

(David-Morrison et al., 2016)

Tor^ΔP larvae show relatively mild dendrite growth defects in the large C4da dendritic arbors.

(Lin et al., 2015)

Tor^ΔP/+ heterozygote adults are significantly lighter compared to wild-type. The females eclose slightly earlier under standard nutrition than wild-type but at the same time as wild-type if nutrition is limited. Adult females have smaller wings as the cells are smaller compared to wild-type but their number is not changed.

(Wu et al., 2015)

Tor^ΔP/+ flies have eyes similar to wild-type.

(Adamson et al., 2014)

In Tor^ΔP germline clones, 67% of eight-cell cysts contain pro-oocytes that have prematurely transitioned from the mitotic to the meiotic cycle.

(Wei et al., 2014)

Tor^ΔP MARCM neuroblast clones exhibit developmental axon regrowth defects.

(Yaniv et al., 2012)

Homozygous dendrite arborization neuron clones show a severe and highly penetrant simplification of the dendritic arbors, with significant reductions in both the number and length of dendritic branches.

(Koike-Kumagai et al., 2009)

In the eye imaginal discs, Tor^ΔP mutant cells proliferate more slowly than their wild-type twin spot control cells.

(Juhász et al., 2008)

Cells in homozygous clones in the fat body are 70% smaller than surrounding wild-type cells.

(Scott et al., 2007)

Mosaic Tor^ΔP mutant clones show a nearly complete block of TR-avidin uptake.

(Hennig et al., 2006)

BrdU incorporation is normal in somatic clones of Tor^ΔP homozygous cells in the late third instar eye disc.

(Mandal et al., 2005)

Loss of Tor activity causes induction of autophagy in normally fed animals. Larvae show reduced size, as do the cells of the fat body. Lethality occurs late in the larval stages.

(Scott et al., 2004)

Clones of Tor^ΔP homozygous wing disc cells show a marked reduction in cell size and an increase in the population of cells in G1 compared to wild-type cells from the same discs.

(Saucedo et al., 2003)

Homozygotes hatch at normal rates, but grow more slowly than normal and eventually arrest during larval development, reaching only 24% the mass of wild-type controls. The mutants remain viable and active during an extended larval period of about 30 days and eventually die without pupating. Homozygous somatic clones in the adult produces mutant cells markedly reduced in size. Clones in the wing are approximately half the size of controls. When Tor^ΔP clones are compared to wild-type sister clones, in developing imaginal discs, they are similar in size 48 hours after induction, but by 72-96 hours they contain significantly fewer cells. In addition lone twin spots lacking a mutant sister are occasionally observed, indicating that at some frequency Tor^ΔP homozygous cells are eliminated from the disc epithelium. FACS analysis of clones in the developing imaginal discs reveals a decrease in cell size of 30% observed in all phases of the cell cycle. Cell cycle phasing is also considerably different to that of controls, with relatively more cells in G₁. and fewer in S and G₂ phases. When salivary glands are examined from Tor^ΔP mutant larvae a phenotypes affecting both polytene gland cells and the imaginal ring cells are seen. The endoreplicative cells undergo only four or five rounds of replication before entering quiescence, reaching a ploidy 16 ro 32 C and a size about 10% of wild-type. The imaginal rings of these larvae contain approximately fivefold fewer cells than wild-type. When homozygous mutant clones are examined in the wing imaginal disc, the nucleolar area is approximately half the size seen in wild-type cells. Also the appearance of fat body cells in the larva is changed by an aggregation of lipid vesicles. At 3-4 days after egg deposition (AED), both endoreplicative and mitotic tissues are found to cycle normally in Tor^ΔP homozygotes (as measured by BrDU incorporation). In contrast, by 5-6 days AED all endoreplicative tissues including the gut fat body and salivary glands fail to incorporate BrDU. Whereas neuroblasts continue to cycle. The same is seen at 10d AED.

(Zhang et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

mTor^ΔP has decreased cell size | somatic clone phenotype, enhanceable by Atg1^UAS.cSa/Scer\GAL4^Act5C.PP

(Scott et al., 2007)

mTor^ΔP has lethal | larval stage phenotype, enhanceable by Atg1^Δ3D

(Scott et al., 2004)

mTor^ΔP has abnormal cell size phenotype, enhanceable by Atg5^RNAi.UAS/Scer\GAL4^αTub84B.PL

(Scott et al., 2004)

mTor^ΔP has abnormal developmental rate phenotype, enhanceable by Atg5^RNAi.UAS/Scer\GAL4^αTub84B.PL

(Scott et al., 2004)

NOT Enhanced by

Statement

Reference

mTor^ΔP has abnormal neuroanatomy | adult stage | somatic clone phenotype, non-enhanceable by SREBP^CA.UAS.cUa/Scer\GAL4^{DIP-γ-MI03222-GAL4}

(Luo et al., 2020)

mTor^ΔP has decreased cell size | somatic clone phenotype, non-enhanceable by Pten^dj189

(Zhang et al., 2000)

Suppressed by

Statement

Reference

mTor^ΔP has abnormal neuroanatomy | somatic clone | adult stage phenotype, suppressible by SREBP^UAS.Exel/Scer\GAL4^{DIP-γ-MI03222-GAL4}

(Luo et al., 2020)

mTor^ΔP has abnormal neuroanatomy | somatic clone | adult stage phenotype, suppressible by sev⁴/sev⁴

(Luo et al., 2020)

mTor^ΔP has abnormal neuroanatomy | somatic clone | adult stage phenotype, suppressible by babo^DN.UAS.cUa/Scer\GAL4^{DIP-γ-MI03222-GAL4}

(Luo et al., 2020)

mTor^ΔP has abnormal cell size phenotype, suppressible by Scer\GAL4^αTub84B.PL/S6k^TE.UAS

(Scott et al., 2004)

NOT suppressed by

Statement

Reference

mTor^ΔP has decreased cell size | third instar larval stage | somatic clone - Minute background phenotype, non-suppressible by Rheb^{EP50.084-loxP}/Scer\GAL4^Tub.PU

(Devilliers et al., 2021)

mTor^ΔP has decreased cell size | third instar larval stage | somatic clone - Minute background phenotype, non-suppressible by Pten¹¹⁷/Pten¹¹⁷

(Devilliers et al., 2021)

mTor^ΔP has abnormal neuroanatomy | somatic clone | adult stage phenotype, non-suppressible by SREBP^CA.UAS.cUa/Scer\GAL4^{DIP-γ-MI03222-GAL4}

(Luo et al., 2020)

mTor^ΔP has decreased occurrence of cell division | somatic clone | third instar larval stage phenotype, non-suppressible by Thor^k13517/Thor^k13517

(Kim et al., 2017)

mTor^ΔP has abnormal mitotic cell cycle | somatic clone phenotype, non-suppressible by Scer\GAL4^αTub84B.PL/Rheb^UAS.cSa

(Saucedo et al., 2003)

mTor^ΔP has decreased cell size | somatic clone phenotype, non-suppressible by Scer\GAL4^αTub84B.PL/Rheb^UAS.cSa

(Saucedo et al., 2003)

mTor^ΔP has decreased cell size | somatic clone phenotype, non-suppressible by Pten^dj189

(Zhang et al., 2000)

Enhancer of

Statement

Reference

Tor[+]/mTor^ΔP is an enhancer of visible phenotype of Pi3K92E^{D954A.UAS.Tag:MYC}, Scer\GAL4^Bx-MS1096

(Coelho et al., 2005)

mTor^ΔP is an enhancer of lethal | pupal stage phenotype of Atg1^Δ3D

(Scott et al., 2004)

NOT Enhancer of

Statement

Reference

mTor^ΔP/mTor^ΔP is a non-enhancer of abnormal neuroanatomy | adult stage | somatic clone phenotype of InR^K1409A.UAS, Scer\GAL4^{DIP-γ-MI03222-GAL4}

(Luo et al., 2020)

Suppressor of

Statement

Reference

mTor^ΔP/mTor^ΔP is a suppressor of abnormal neuroanatomy | somatic clone | adult stage phenotype of sev⁴

(Luo et al., 2020)

mTor^ΔP/mTor^ΔP is a suppressor | partially of abnormal neuroanatomy | somatic clone | adult stage phenotype of Scer\GAL4^{DIP-γ-MI03222-GAL4}, babo^DN.UAS.cUa

(Luo et al., 2020)

Tor[+]/mTor^ΔP is a suppressor of abnormal neurophysiology | third instar larval stage phenotype of Lrrk^UAS.cIa, Scer\GAL4^Mhc.PW

(Penney et al., 2016)

Tor[+]/mTor^ΔP is a suppressor | partially of flightless | progressive phenotype of Pten¹/Pten⁵

(Mensah et al., 2015)

mTor^ΔP is a suppressor of hyperplasia | conditional | somatic clone phenotype of Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C, Scer\GAL80^αTub84B.PL

(Zeng et al., 2010)

Tor[+]/mTor^ΔP is a suppressor | partially of lethal | larval stage phenotype of gig¹⁹³/gig¹⁰⁹

(Zhang et al., 2006)

NOT Suppressor of

Statement

Reference

mTor^ΔP/mTor^ΔP is a non-suppressor of abnormal neuroanatomy | somatic clone | adult stage phenotype of InR^K1409A.UAS, Scer\GAL4^{DIP-γ-MI03222-GAL4}

(Luo et al., 2020)

Tor[+]/mTor^ΔP is a non-suppressor of lethal | larval stage phenotype of gig¹⁹³/gig¹⁰⁹, mTor^+t9.4

(Zhang et al., 2006)

Tor[+]/mTor^ΔP is a non-suppressor | partially of lethal | larval stage phenotype of gig¹⁹³/gig¹⁰⁹

(Zhang et al., 2006)

Other

Statement

Reference

Df(2R)Sema2b-C4, mTor^ΔP has abnormal neuroanatomy | third instar larval stage phenotype

(Meltzer et al., 2016)

GluRIIA^SP16/Df(2L)cl-h4, mTor^E161K/mTor^ΔP has abnormal neurophysiology | larval stage phenotype

(Penney et al., 2012)

S6k[+]/S6k^l-1, mTor^ΔP has abnormal neuroanatomy | dominant phenotype

(Koike-Kumagai et al., 2009)

Sin1[+]/Sin1^e03756, mTor^ΔP has abnormal neuroanatomy | dominant phenotype

(Koike-Kumagai et al., 2009)

mTor^ΔP, rictor[+]/rictor^Δ2 has abnormal neuroanatomy | dominant phenotype

(Koike-Kumagai et al., 2009)

mTor^ΔP, trc¹/trc[+] has abnormal neuroanatomy phenotype

(Koike-Kumagai et al., 2009)

Phenotype Manifest In

Enhanced by

Statement

Reference

mTor^ΔP has fat body | somatic clone phenotype, enhanceable by Atg1^UAS.cSa/Scer\GAL4^Act5C.PP

(Scott et al., 2007)

mTor^ΔP has fat body phenotype, enhanceable by Atg5^RNAi.UAS/Scer\GAL4^αTub84B.PL

(Scott et al., 2004)

NOT Enhanced by

Statement

Reference

mTor^ΔP has distal medullary amacrine neuron Dm8 | adult stage | somatic clone phenotype, non-enhanceable by SREBP^CA.UAS.cUa/Scer\GAL4^{DIP-γ-MI03222-GAL4}

(Luo et al., 2020)

mTor^ΔP has dendrite | adult stage | somatic clone phenotype, non-enhanceable by SREBP^CA.UAS.cUa/Scer\GAL4^{DIP-γ-MI03222-GAL4}

(Luo et al., 2020)

mTor^ΔP has cell cycle | somatic clone phenotype, non-enhanceable by Pten^dj189

(Zhang et al., 2000)

Suppressed by

Statement

Reference

mTor^ΔP has distal medullary amacrine neuron Dm8 | somatic clone | adult stage phenotype, suppressible by SREBP^UAS.Exel/Scer\GAL4^{DIP-γ-MI03222-GAL4}

(Luo et al., 2020)

mTor^ΔP has dendrite | somatic clone | adult stage phenotype, suppressible by SREBP^UAS.Exel/Scer\GAL4^{DIP-γ-MI03222-GAL4}

(Luo et al., 2020)

mTor^ΔP has distal medullary amacrine neuron Dm8 | somatic clone | adult stage phenotype, suppressible by sev⁴/sev⁴

(Luo et al., 2020)

mTor^ΔP has dendrite | somatic clone | adult stage phenotype, suppressible by sev⁴/sev⁴

(Luo et al., 2020)

mTor^ΔP has distal medullary amacrine neuron Dm8 | somatic clone | adult stage phenotype, suppressible by babo^DN.UAS.cUa/Scer\GAL4^{DIP-γ-MI03222-GAL4}

(Luo et al., 2020)

mTor^ΔP has dendrite | somatic clone | adult stage phenotype, suppressible by babo^DN.UAS.cUa/Scer\GAL4^{DIP-γ-MI03222-GAL4}

(Luo et al., 2020)

mTor^ΔP has cell cycle phenotype, suppressible by CycE^hs.PR

(Zhang et al., 2000)

NOT suppressed by

Statement

Reference

mTor^ΔP has larval fat cell | third instar larval stage | somatic clone - Minute background phenotype, non-suppressible by Rheb^{EP50.084-loxP}/Scer\GAL4^Tub.PU

(Devilliers et al., 2021)

mTor^ΔP has larval fat cell | third instar larval stage | somatic clone - Minute background phenotype, non-suppressible by Pten¹¹⁷/Pten¹¹⁷

(Devilliers et al., 2021)

mTor^ΔP has distal medullary amacrine neuron Dm8 | somatic clone | adult stage phenotype, non-suppressible by SREBP^CA.UAS.cUa/Scer\GAL4^{DIP-γ-MI03222-GAL4}

(Luo et al., 2020)

mTor^ΔP has dendrite | somatic clone | adult stage phenotype, non-suppressible by SREBP^CA.UAS.cUa/Scer\GAL4^{DIP-γ-MI03222-GAL4}

(Luo et al., 2020)

mTor^ΔP has eye disc | somatic clone | third instar larval stage phenotype, non-suppressible by Thor^k13517/Thor^k13517

(Kim et al., 2017)

mTor^ΔP has cell cycle | somatic clone phenotype, non-suppressible by Pten^dj189

(Zhang et al., 2000)

Enhancer of

Statement

Reference

Tor[+]/mTor^ΔP is an enhancer of eye phenotype of EBV\BZLF1^GMR.PA

(Adamson et al., 2014)

mTor^ΔP is an enhancer of eye phenotype of EBV\BZLF1^GMR.PA

(Adamson and Lajeunesse, 2012)

Tor[+]/mTor^ΔP is an enhancer of wing phenotype of Pi3K92E^{D954A.UAS.Tag:MYC}, Scer\GAL4^Bx-MS1096

(Coelho et al., 2005)

NOT Enhancer of

Statement

Reference

mTor^ΔP/mTor^ΔP is a non-enhancer of distal medullary amacrine neuron Dm8 | adult stage | somatic clone phenotype of InR^K1409A.UAS, Scer\GAL4^{DIP-γ-MI03222-GAL4}

(Luo et al., 2020)

mTor^ΔP/mTor^ΔP is a non-enhancer of dendrite | adult stage | somatic clone phenotype of InR^K1409A.UAS, Scer\GAL4^{DIP-γ-MI03222-GAL4}

(Luo et al., 2020)

Tor[+]/mTor^ΔP is a non-enhancer of wing phenotype of pyd^tam/pyd^ex147

(Djiane et al., 2011)

Suppressor of

Statement

Reference

mTor^ΔP/mTor^ΔP is a suppressor of distal medullary amacrine neuron Dm8 | somatic clone | adult stage phenotype of sev⁴

(Luo et al., 2020)

mTor^ΔP/mTor^ΔP is a suppressor of dendrite | somatic clone | adult stage phenotype of sev⁴

(Luo et al., 2020)

mTor^ΔP/mTor^ΔP is a suppressor | partially of distal medullary amacrine neuron Dm8 | somatic clone | adult stage phenotype of Scer\GAL4^{DIP-γ-MI03222-GAL4}, babo^DN.UAS.cUa

(Luo et al., 2020)

mTor^ΔP/mTor^ΔP is a suppressor | partially of dendrite | somatic clone | adult stage phenotype of Scer\GAL4^{DIP-γ-MI03222-GAL4}, babo^DN.UAS.cUa

(Luo et al., 2020)

Tor[+]/mTor^ΔP is a suppressor of embryonic/larval neuromuscular junction | third instar larval stage phenotype of Lrrk^UAS.cIa, Scer\GAL4^Mhc.PW

(Penney et al., 2016)

Tor[+]/mTor^ΔP is a suppressor | partially of eye phenotype of EBV\BRLF1^GMR.PA

(Adamson et al., 2014)

Tor[+]/mTor^ΔP is a suppressor | partially of interommatidial bristle phenotype of EBV\BRLF1^GMR.PA

(Adamson et al., 2014)

Tor[+]/mTor^ΔP is a suppressor | partially of ommatidium phenotype of EBV\BRLF1^GMR.PA

(Adamson et al., 2014)

mTor^ΔP is a suppressor of eye phenotype of EBV\BRLF1^GMR.PA

(Adamson and Lajeunesse, 2012)

mTor^ΔP is a suppressor of adult Malpighian tubule | conditional | somatic clone phenotype of Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C, Scer\GAL80^αTub84B.PL

(Zeng et al., 2010)

NOT Suppressor of

Statement

Reference

mTor^ΔP/mTor^ΔP is a non-suppressor of distal medullary amacrine neuron Dm8 | somatic clone | adult stage phenotype of InR^K1409A.UAS, Scer\GAL4^{DIP-γ-MI03222-GAL4}

(Luo et al., 2020)

mTor^ΔP/mTor^ΔP is a non-suppressor of dendrite | somatic clone | adult stage phenotype of InR^K1409A.UAS, Scer\GAL4^{DIP-γ-MI03222-GAL4}

(Luo et al., 2020)

Other

Statement

Reference

Df(2R)Sema2b-C4, mTor^ΔP has larval multidendritic class IV neuron | third instar larval stage phenotype

(Meltzer et al., 2016)

Df(2R)Sema2b-C4, mTor^ΔP has dendrite | third instar larval stage phenotype

(Meltzer et al., 2016)

GluRIIA^SP16/Df(2L)cl-h4, mTor^E161K/mTor^ΔP has embryonic/larval neuromuscular junction | larval stage phenotype

(Penney et al., 2012)

S6k[+]/S6k^l-1, mTor^ΔP has dendrite phenotype

(Koike-Kumagai et al., 2009)

mTor^ΔP, trc¹/trc[+] has dendrite phenotype

(Koike-Kumagai et al., 2009)

mTor^ΔP, trc¹/trc[+] has larval multidendritic class IV neuron phenotype

(Koike-Kumagai et al., 2009)

S6k[+]/S6k^l-1, mTor^ΔP has larval dorsal multidendritic neuron ddaC phenotype

(Koike-Kumagai et al., 2009)

Sin1[+]/Sin1^e03756, mTor^ΔP has dendrite phenotype

(Koike-Kumagai et al., 2009)

Sin1[+]/Sin1^e03756, mTor^ΔP has larval dorsal multidendritic neuron ddaC phenotype

(Koike-Kumagai et al., 2009)

mTor^ΔP, rictor[+]/rictor^Δ2 has dendrite phenotype

(Koike-Kumagai et al., 2009)

mTor^ΔP, rictor[+]/rictor^Δ2 has larval dorsal multidendritic neuron ddaC phenotype

(Koike-Kumagai et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

The delay in G1/S transition during the second mitotic wave in third instar larval eye discs displayed by Tor^ΔP homozygous somatic clones is not suppressed by additional clonal homozygosity for Thor^k13517.

(Kim et al., 2017)

The level of non-contacting dendrite crossing in class IV dendrite arborizing larval neurons is significantly increased in Tor^ΔP;Df(2R)Sema-2b-C4 double mutants compared to either Tor^ΔP/+ or Df(2R)Sema-2b-C4/+ heterozygotes.

(Meltzer et al., 2016)

Tor^ΔP/+ suppresses the increase in excitatory junction current amplitude and quantal content seen in larvae NMJs expressing Lrrk^Scer\UAS.cIa under the control of Scer\GAL4^Mhc.PW.

(Penney et al., 2016)

Wings from pyd^ex147/pyd^tam flies are broader compared to control wings, and this phenotype is not modified in a Tor^ΔP/+ background.

(Djiane et al., 2011)

The body weight of Tor^ΔP/+ flies is increased by the presence of fkh¹/+.

(Bülow et al., 2010)

The dendritic branches of ddaC neurons in Tor^ΔP/+ ; S6k^l-1/+ double heterozygous larvae have fewer branch points than wild-type controls.

The dendritic branches of ddaC neurons in Tor^ΔP/+ ; Sin1^e03756/+ and in Tor^ΔP/+ ; rictor^Δ2/+ double heterozygous larvae show increased crossing over of each other, indicating a tiling defect.

Class IV da neurons of Tor^ΔP/+ ; trc¹/+ double heterozygous larvae show defects in dendritic tiling, with a significantly higher number of dendritic branches crossing one another compared to wild type.

(Koike-Kumagai et al., 2009)

Expression of Atg1^Scer\UAS.cSa under the control of Scer\GAL4^Act5C.PP in Tor^ΔP clones in the fat body results in a further decrease in cells size compared to Tor^ΔP single mutant clones.

(Scott et al., 2007)

Around 60% of gig¹⁰⁹/gig¹⁹³; Tor^ΔP/+ flies survive to the pupal, but not the adult stage. However, one copy of the Tor^+t9.4 transgene blocks the ability of Tor^ΔP/+ to rescue gig¹⁰⁹/gig¹⁹³ flies to pupal viability.

(Zhang et al., 2006)

Expression of Atg5^{dsRNA.Scer\UAS} catastrophically arrests development of Tor^ΔP; larvae are 6-fold smaller than Tor^ΔP mutants alone. Fat body cell size is reduced a further 2-fold. Atg1^Δ3D,Tor^ΔP double mutants show lethality at the embryonic stage.

(Scott et al., 2004)

The small size and increase in the proportion of cells in G1 seen in cells from Tor^ΔP homozygous wing disc clones, is unaffected by the expression of Rheb^Scer\UAS.cSa in the clone cells (driven by Scer\GAL4^αTub84B.PL when Scer\GAL80^αTub84B.PL is removed in the same mitotic recombination event that creates the Tor^ΔP homozygous clone).

The small size and increase in proportion of cells in G1 seen in cell from Tor^ΔP homozygous wing disc clones, is unafected by the expression of Rheb^Scer\UAS.cSa in the clone cells (driven by Scer\GAL4^αTub84B.PL when Scer\GAL80^αTub84B.PL is removed in the same mitotic recombination event that creates the Tor^ΔP homozygous clone.)

(Saucedo et al., 2003)

The addition of Pten^dj189 to Tor^ΔP mutant clones shows no effect on the Tor^ΔP phenotype. The addition of CycE^hs.PR bypasses the cell cycle arrest seen in Tor^ΔP larvae.

(Zhang et al., 2000)

Xenogenetic Interactions

Statement

Reference

Tor^ΔP/+ partially suppresses the eye-phenotype associated with EBV\BRLF1^GMR.PA-expression.

Tor^ΔP/+ partially enhances the eye-phenotype associated with EBV\BRLF1^GMR.PA-expression.

(Adamson et al., 2014)

Complementation and Rescue Data

Rescued by

mTor^ΔP is rescued by mTor^{WT.UAS.Tag:FLAG}/Scer\GAL4^{DIP-γ-MI03222-GAL4}

(Luo et al., 2020)

mTor^E161K/mTor^ΔP is rescued by mTor^{WT.UAS.Tag:FLAG}/Scer\GAL4^Mhc.PW

(Penney et al., 2012)

mTor^ΔP is rescued by mTor^+t9.4

(Zhang et al., 2000)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

7014

y¹ w^*; mTor^ΔP P{neoFRT}40A/CyO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

TOR delP

(Liu et al., 2017)

TOR-ΔP

(Romero-Pozuelo et al., 2017)

TOR^ΔP

(Sanal et al., 2023, Kang et al., 2018, Kim et al., 2017, Kaplan et al., 2008, Cygnar et al., 2005)

Tor^DeltaP

(Lee et al., 2018, Sarov et al., 2016, Adamson et al., 2014, Adamson and Lajeunesse, 2012)

Tor^ΔP1

(Djiane et al., 2011)

dTOR^ΔP

(David-Morrison et al., 2016)

dTor^ΔP

(Lin et al., 2015)

mTor^ΔP

tor^ΔP

(Jacomin et al., 2021, Meltzer et al., 2016)

Name Synonyms

Secondary FlyBase IDs

References (50)

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