Open Close
General Information
Symbol
Dmel\Rab7UAS.GFP
Species
D. melanogaster
Name
FlyBase ID
FBal0120653
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-GFP-Rab7, UAS-Rab7-GFP, Rab7-GFP, UAS-GFP:Rab7, UAS-Rab7GFP, GFP-Rab7, Rab7GFP, UASrab7-GFP
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference
UAS regulatory sequences drive expression of Rab7 tagged at the N-terminal end with GFP.
Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Expression of Rab7Scer\UAS.T:Avic\GFP under the control of Scer\GAL4GMR.PFa does not perturb the structure or appearance of the adult eye compared to controls.
Wing discs expressing Rab7Scer\UAS.T:Avic\GFP contain enlarged late endosomes.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhancer of
Suppressor of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference
The dot-like small eye phenotype characteristic for flies expressing egrScer\UAS.cMa under the control of Scer\GAL4GMR.PFa is partially suppressed by co-expression of Rab7Scer\UAS.T:Avic\GFP.
Co-expression of Rab7Scer\UAS.T:Avic\GFP dramatically increases the incidence of tears in the leg epithelium in animals with moderate expression of RhoGAP68FScer\UAS.T:Disc\RFP-mCherry under the control of Scer\GAL4Dll-md23 (penetrance increases from 12% to 74%).
Xenogenetic Interactions
Statement
Reference
Expression of Rab7Scer\UAS.T:Avic\GFP does not lead to a significant difference in the the locomotion activity of flies expressing Hsap\SNCAA53T.Scer\UAS under the control of Scer\GAL4elav.PLu at 5 days old, however, at 15 and 25 days old results in significantly improved locomotion, delaying the onset of locomotion defects seen in flies expressing Hsap\SNCAA53T.Scer\UAS under the control of Scer\GAL4elav.PLu.
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Rab7Scer\UAS.T:Avic\GFP
Rab7UAS.GFP
Name Synonyms
Secondary FlyBase IDs
    References (52)