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General Information
Symbol
Dmel\Fmr1UAS.cWa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Wan
FlyBase ID
FBal0120821
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-dfmr1, UAS-Fmr1
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference
UAS sequences drive expression of the Fmr1 open reading frame.
Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Scer\GAL4elav-C155-driven expression of Fmr1Scer\UAS.cWa leads to adult locomotion deficit (reduced climbing ability) compared to controls.
Expression of Fmr1Scer\UAS.cWa under the control of Scer\GAL4109(2)80 results in defects in crawling behaviour in wandering larvae; the larvae show an increase in the time percentage spent on linear locomotion compared to controls and the duration of the linear locomotion is increased. The average direction change (direction change is defined as the difference in direction from one frame to the next in the analysis) is reduced compared to controls.
When Fmr1Scer\UAS.T:Avic\GFP is driven by Scer\GAL4109(2)80 the number of terminal dendritic processes in both the ventral and dorsal dendritic arborising neurons (DAs). The lengths of the remining terminal processes is also greatly reduced. This phenotype is 100% penetrant. The major dendritic branches are still capable of extending more than fivefold during larval development, however most terminal processes fail to form or extend even at the first instar stage.
Over expression of Fmr1Scer\UAS.cWa when driven by Scer\GAL4dpp.blk1 causes cell loss in the wing, a decrease in cells in seen between longitudinal veins 3 and 4, as well as loss of the anterior crossvein. Over expression of Fmr1Scer\UAS.cWa when driven by Scer\GAL4vg.PM causes cell loss in the wing - cell loss at the wing margin is seen with 100% penetrance. Expression of Fmr1Scer\UAS.cWa in the eye disc when driven by Scer\GAL4hs.2sev causes an increase in apoptotic cell death behind the morphogenetic furrow. The adult eye lack some photoreceptor cells and pigment cells. Overexpression also leads to the alteration of rhabdomere shape.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressed by
Enhancer of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference
The mushroom body morphology defects in Nab2ex3 adult mutants are exacerbated by Scer\GAL4ey-OK107-driven expression of Fmr1Scer\UAS.cWa. The locomotion deficit (decreased climbing ability) characteristic for adult flies expressing Nab2GD11745 under the control of Scer\GAL4elav-C155 is worsened further by co-expression of Fmr1Scer\UAS.cWa (which on its own also induces climbing ability defects).
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Expression of Fmr1Scer\UAS.cWa under the control of Scer\GAL4c747 rescues the learning phenotype of Fmr13 mutants. Expression of Fmr1Scer\UAS.cWa under the control of Scer\GAL4Mef2.247 rescues the learning phenotype of Fmr13 mutants. Expression of Fmr1Scer\UAS.cWa under the control of Scer\GAL4Alp4-c507 fails to rescue the learning phenotype of Fmr13 mutants. Expression of Fmr1Scer\UAS.cWa under the control of Scer\GAL4NP1131 fails to rescue the learning phenotype of Fmr13 mutants.
Expression of Fmr1Scer\UAS.cWa under the control of Scer\GAL4109(2)80 rescues the defects in crawling behaviour seen in wandering Fmr14.L larvae.
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Fmr1Scer\UAS.cWa
Fmr1UAS.cWa
Name Synonyms
Saccharomyces cerevisiae UAS construct a of Wan
Secondary FlyBase IDs
    References (7)