Allele Dmel\Fmr1^{I307N.Scer\UAS}

General Information
Symbol	Dmel\Fmr1^{I307N.Scer\UAS}	Species	D. melanogaster
Name		FlyBase ID	FBal0120822
Feature type	allele	Associated gene	Dmel\Fmr1

Allele class
Mutagen	in vitro construct - amino acid replacement
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	in vitro construct - amino acid replacement (Wan et al., 2000)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	Fmr1^Scer\UAS.cWa (Wan et al., 2000)
Nature of the lesion	Statement Reference Construct: Amino acid replacement: I307N. (Wan et al., 2000)
Carried in construct	P{UAS-Fmr1.I307N} (Morales et al., 2002, Wan et al., 2000)
Cytology
Phenotypic Data
Phenotypic Class
	neuroanatomy defective, with Scer\GAL4^ato.3.6 (Morales et al., 2002)
Phenotype Manifest In
	dorsal cluster neuron, with Scer\GAL4^ato.3.6 (Morales et al., 2002) dorsal cluster neuron & neurite, with Scer\GAL4^ato.3.6 (Morales et al., 2002) eye, with Scer\GAL4^hs.2sev (Wan et al., 2000) ommatidium, with Scer\GAL4^hs.2sev (Wan et al., 2000) rhabdomere, with Scer\GAL4^hs.2sev (Wan et al., 2000)
Detailed Description
	Statement Reference Phenotype similar to but less severe than that in loss of function mutants. Only occasionally do fibers cross from the lobula to the medulla, but those that do form aberrant projection and branching patterns within the medulla. Effect is the same whether in a wild type or a Fmr1^Δ113M/Fmr1^Δ83M background. (Morales et al., 2002) Expression of Fmr1^{I307N.Scer\UAS} in the eye driven by Scer\GAL4^hs.2sev produces a mild eye phenotype. Overexpression also leads to the alteration of rhabdomere shape. (Wan et al., 2000)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Fmr1^{I307N.Scer\UAS}
Name Synonym
Secondary FlyBase IDs

References ( 2 )
Research paper	Morales et al., 2002, Neuron 34(6): 961--972 Drosophila Fragile X protein, DFXR, regulates neuronal morphology and function in the brain. [FBrf0149142] Wan et al., 2000, Mol. Cell. Biol. 20(22): 8536--8547 Characterization of dFMR1, a Drosophila melanogaster Homolog of the Fragile X Mental Retardation Protein. [FBrf0130150]

Allele Dmel\Fmr1I307N.Scer\UAS

Allele Dmel\Fmr1^{I307N.Scer\UAS}