Allele Dmel\Dredd^D55

General Information
Symbol	Dmel\Dredd^D55	Species	D. melanogaster
Name		FlyBase ID	FBal0120963
Feature type	allele	Associated gene	Dmel\Dredd

Allele class	amorphic allele - genetic evidence
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class	amorphic allele - genetic evidence (Leulier et al., 2000)
Mutagen	ethyl methanesulfonate (Leulier et al., 2000)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: W195@. (Leulier et al., 2000)
Cytology
Phenotypic Data
Phenotypic Class
	radiation resistant (Georgel et al., 2001) viable (Leulier et al., 2000)
Phenotype Manifest In

Detailed Description
	Statement Reference Dredd[D55] homozygotes exhibit wild-type apoptosis of vCrz neurons, with no viable vCrz neurons detected at 7 hours after puparium formation. (Lee et al., 2011) Mutant flies that are infected with E. coli one day prior to infection with either X. nematophila or P. luminescens are highly susceptible to infection by either X. nematophila or P. luminescens (in contrast to wild-type flies which show increased survival after infection with either X. nematophila or P. luminescens due to partial protection by the prior infection with E. coli). (Aymeric et al., 2010) The proportion of Dredd^D55 homozygous pupae (24 hours APF) surviving to adulthood after UV irradiation (50,000 μJ/cm²) is significantly higher than for wild-type. (Georgel et al., 2001)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
NOT Suppressor of
Statement Reference Dredd^D55/Dredd^D55 is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, egr^Scer\UAS.cMa (Moreno et al., 2002, Moreno et al., 2002)
Additional Comments
Genetic Interactions
Statement Reference Homozygosity for Dredd^D55 does not supress the ablation of adult eye tissue seen in egr^Scer\UAS.cMa; Scer\GAL4^GMR.PF animals. (Moreno et al., 2002)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	D55 (Leulier et al., 2000) dredd^D55 (Georgel et al., 2001, Moreno et al., 2002, Lee et al., 2011) Dredd^D55 (Aymeric et al., 2010)
Name Synonym
Secondary FlyBase IDs

References ( 7 )
Research paper	Lee et al., 2011, J. Comp. Neurol. 519(1): 34--48 Drosophila caspases involved in developmentally regulated programmed cell death of peptidergic neurons during early metamorphosis. [FBrf0212368] Aymeric et al., 2010, Molec. Immunol. 47(14): 2342--2348 Imd pathway is involved in the interaction of Drosophila melanogaster with the entomopathogenic bacteria, Xenorhabdus nematophila and Photorhabdus luminescens. [FBrf0211463] Choe et al., 2002, Science 296(5566): 359--362 Requirement for a peptidoglycan recognition protein (PGRP) in relish activation and antibacterial immune responses in Drosophila. [FBrf0147192] Moreno et al., 2002, Curr. Biol. 12(14): 1263--1268 Evolution of TNF signaling mechanisms: JNK-dependent apoptosis triggered by Eiger, the Drosophila homolog of the TNF superfamily. [FBrf0151836] Georgel et al., 2001, Dev. Cell 1(4): 503--514 Drosophila immune deficiency (IMD) is a death domain protein that activates antibacterial defense and can promote apoptosis. [FBrf0141455] Leulier et al., 2000, EMBO Rep. 1(4): 353--358 The Drosophila caspase Dredd is required to resist gram-negative bacterial infection. [FBrf0133276]
Letter	Michel et al., 2001, Nature 414(6865): 756--759 Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein. [FBrf0141671]

Allele Dmel\DreddD55

Allele Dmel\Dredd^D55