|Feature type||allele||Associated gene||Dmel\lea|
|Also Known As||robo25|
|Map ( GBrowse )|
|Allele class||loss of function allele|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
Amino acid replacement: W666@ (revision of data in FBrf0132258). Amino acid replacements are relative to the 1406 amino acid residue predicted protein.
Amino acid replacement: W723@. See Dickson, 2001.3.14, personal communication for subsequent revision of this information.
|Phenotype Manifest In|
learobo2-4/learobo2-5 and learobo2-1/learobo2-5 have defects in the ellipsoid body and fan-shaped body. 16% of mushroom bodies lack dorsal projections in learobo2-1/learobo2-5 animals, and 32% have a partial median projection. In addition, the diameter of the peduncle is larger than in wild-type animals. 12% of mushroom bodies lack dorsal projections in learobo2-4/learobo2-5 animals, and 8% have a partial median projection. In addition, the the diameter of peduncle is larger than in wild-type animals.
|Phenotype Manifest In|
learobo2-5, robounspecified has presumptive embryonic/larval central nervous system phenotype, enhanceable by Abl2/Abl[+]
|NOT suppressed by|
|NOT Enhancer of|
|NOT Suppressor of|
The frequency of ectopic crossing of the midline by axons in the central nervous system seen in robounspecified learobo2-5 embryos is increased by Abl2/+.
robo1/learobo2-5 embryos show an enhancement of the embryonic nervous system phenotype seen in these embryos. The pCC axon fasciculates with its contralateral homologue to extend anteriorly right along the midline. The aCC axons also frequently cross the midline in these embryos. By stage 16, all axons have joined the single midline bundle. Double mutants also exhibit a embryonic muscle phenotype. Ventral muscles normally attach to the epidermis beneath the lateral central nervous system (CNS). In robo1/learobo2-5 mutants, these muscles frequently extend across the dorsal surface of the CNS. Some muscles still attach to beneath the CNS though often somewhat close to the midline than usual. The addition of learobo2-5 to comm1 embryos has no effect on the number of commissures crossing the midline in the ventral nerve cords in these mutants. The addition of comm1 to robo1, learobo2-5 embryos has no effect on the ventral nerve cord phenotype.
|Complementation & Rescue Data|
|Stocks ( 0 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 2 )|
|Secondary FlyBase IDs|
|References ( 6 )|
|Personal communication to FlyBase|