|Feature type||allele||Associated gene||Dmel\lea|
|Also Known As||robo21|
|Allele class||loss of function allele|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
Amino acid replacement: R384@ (revision of data in FBrf0132258). Amino acid replacements are relative to the 1406 amino acid residue predicted protein.
Amino acid replacement: R441@. See Dickson, 2001.3.14, personal communication for subsequent revision of this information.
|Phenotype Manifest In|
olfactory neuron & antennal lobe | somatic clone
learobo2-1/learobo2-5 and learobo2-1/learobo2-4 have defects in the ellipsoid body and fan-shaped body. 16% of mushroom bodies lack dorsal projections in learobo2-1/learobo2-5 animals, and 32% have a partial median projection. In addition, the diameter of the peduncle is larger than in wild-type animals. 34% of mushroom bodies lack dorsal projections in learobo2-4/learobo2-1 animals, and 18% have a partial median projection. The median lobes are positioned more posteriorly than in wild type. In addition, the the diameter of peduncle is larger than in wild-type animals.
learobo2-1/learobo2-1 DM2 glomerulus innervating neurons, produced by mitotic recombination in a learobo2-1/+ background, fail to cross over to the contralateral lobe through the antennal commissure. Instead they terminate at the midline forming small "glomerular-like" structures. Targeting of these neurons to antennal glomerulus DM2 occurs normally, although in many cases the glomeruli appear less intensely innervated (13/16).
The lateral Fas2-expressing fascicle often merges with the intermediate fascicle in learobo2-1/learobo2-4 mutant embryos. Midline crossing defects also occur. 7.9% of embryos show fusion between the medial and intermediate fascicles, 17.1% show fusion between the lateral and and intermediate fascicles and 13.4% show breaks in the lateral fascicle.
|Phenotype Manifest In|
|Complementation & Rescue Data|
|Stocks ( 0 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 2 )|
|Secondary FlyBase IDs|
|References ( 8 )|
|Personal communication to FlyBase|