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General Information
Symbol
Dmel\skdT606
Species
D. melanogaster
Name
FlyBase ID
FBal0121621
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

C21025002T

Amino acid change:

Q7term | skd-PC; Q7term | skd-PD; Q7term | skd-PE; Q7term | skd-PF

Reported amino acid change:

Q7term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: Q7term.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Generation of skdT606 clones specifically in the leg (using Scer\GAL4Dll-em212 and Scer\FLP1Scer\UAS.cUa) and in a Minute background results in severely stunted legs. In an other wild type background, these clones result in tarsal segmentation defects in all three paris of adult legs. Male prothoracic (T1) legs exhibit sex combs with slightly reduced teeth number but mostly aligned sex combs. Legs show strong distal leg shortening, and the most proximal tarsal joint as well as more distal joints are usually abnormal.

Generation of large skdT606 clones specifically in the eye (using Scer\FLP1ey.PB) in a Minute background results in the eye failing to differentiate ommatidia.

Heat-induced ktoT241 clones in the adult notum are associated with loss of bristles.

skdT606 clones in the anterior compartment of the wing disc which touch the anterior-posterior boundary cross the boundary in 58% of cases. skdT606 clones in the wing disc (induced in the first or early second larval instar) that span the dorsal-ventral (DV) boundary often move into one of the two compartments, distorting the compartment boundary. Of skdT606 clones that touch the DV boundary, 41% push the boundary ventrally and 18% push the boundary dorsally.

Clones in the eye contain few or no photoreceptors. The few that remain are found in posterior regions of the clone, and die later in development. Clone size is normal and clones do not interfere with the spread of differentiation-promoting signals. Antennal disc cell fates are also altered.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Other
Statement
Reference
Phenotype Manifest In
NOT suppressed by
Statement
Reference

skdT606 has eye disc phenotype, non-suppressible by hhUAS.cAa/Scer\GAL4ey.PH

skdT606 has eye disc phenotype, non-suppressible by Dl::NΔECN.UAS/Scer\GAL4ey.PH

skdT606 has eye disc phenotype, non-suppressible by cim1-4.UAS.Tag:HA/Scer\GAL4ey.PH

Enhancer of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescued by
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (5)