Allele Dmel\nompB¹

General Information
Symbol	Dmel\nompB¹	Species	D. melanogaster
Name		FlyBase ID	FBal0121649
Feature type	allele	Associated gene	Dmel\nompB

Allele class
Mutagen
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Contains a 1100bp deletion tha removes exon 4 and part of exon 3. This results in a mis-splicing of exon 2 to exon 5 and a frameshift at amino acid 109 that yields a 110 amino acid truncated protein. (Han et al., 2003)
Cytology
Phenotypic Data
Phenotypic Class
	auditory perception defective \| recessive (Eberl et al., 2000) behavior defective \| recessive (Eberl et al., 2000) fertile, with Df(2L)03832MR1, Scer\GAL4^elav-C155, nompB^ΔX.Scer\UAS (Han et al., 2003) fertile (with Df(2L)03832MR1), with Scer\GAL4^elav-C155, nompB^ΔX.Scer\UAS (Han et al., 2003) locomotor behavior defective \| recessive (Eberl et al., 2000) uncoordinated \| recessive (Eberl et al., 2000)
Phenotype Manifest In
	adult antennal nerve (Eberl et al., 2000) leg (Eberl et al., 2000) macrochaeta (Eberl et al., 2000) wing (Eberl et al., 2000)
Detailed Description
	Statement Reference nompB¹/Df(2L)03832MR1 males carrying nompB^ΔX.Scer\UAS driven by Scer\GAL4^elav-C155 are fertile. The offensive competitive ability of sperms from these males is also unaffected; the last-male sperm precedence usually seen is unaffected. (Han et al., 2003) Flies are uncoordinated showing frequent leg crossing and wings held up or out. Walking and righting ability is impaired. Spontaneous or induced (by light or mechanical stimuli) activity is vigorous. Mechanoreceptor potentials are invariably absent in thoracic macrochaete bristles. The sound evoked response (measured via the antennal nerve) is eliminated. ERGs are normal. (Eberl et al., 2000)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescued by	nompB¹/Df(2L)03832MR1 is rescued by Scer\GAL4^elav-C155/nompB^ΔX.Scer\UAS (Han et al., 2003)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	nompB¹ (Enjolras et al., 2012)
Name Synonym
Secondary FlyBase IDs

References ( 3 )
Research paper	Enjolras et al., 2012, J. Cell Biol. 197(2): 313--325 Drosophila chibby is required for basal body formation and ciliogenesis but not for Wg signaling. [FBrf0218054] Han et al., 2003, Curr. Biol. 13(19): 1679--1686 Intraflagellar transport is required in Drosophila to differentiate sensory cilia but not sperm. [FBrf0167401] Eberl et al., 2000, J. Neurosci. 20(16): 5981--5988 Genetically similar transduction mechanisms for touch and hearing in Drosophila. [FBrf0129796]

Allele Dmel\nompB1

Allele Dmel\nompB¹