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General Information
Symbol
Dmel\ktoT241
Species
D. melanogaster
Name
FlyBase ID
FBal0121711
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:
C19837544T
Amino acid change:
Q270term | kto-PA
Reported amino acid change:
Q270term
Comment:
Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Amino acid replacement: Q270term.
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Generation of ktoT241 clones specifically in the leg (using Scer\GAL4Dll-em212 and Scer\FLP1Scer\UAS.cUa) and in a Minute background results in severely stunted legs. In an other wild type background, these clones result in tarsal segmentation defects in all three paris of adult legs. Male prothoracic (T1) legs exhibit sex combs with slightly reduced teeth number but mostly aligned sex combs. Legs show strong distal leg shortening, and the most proximal tarsal joint as well as more distal joints are usually abnormal. Generation of large ktoT241 clones specifically in the eye (using Scer\FLP1ey.PB) in a Minute background results in the eye failing to differentiate ommatidia. Heat-induced ktoT241 clones in the adult notum are associated with loss of bristles. Generation of large Cdk8K185 clones specifically in the eye (using Scer\GAL4ap-md544 and Scer\FLP1Scer\UAS.cUa) in a Minute background results in extensive loss of notal macrochaetes.
ktoT241 clones in the anterior compartment of the wing disc which touch the anterior-posterior boundary often cross into the posterior compartment.
Clones in the eye contain few or no photoreceptors. The few that remain are found in posterior regions of the clone, and die later in development. Clone size is normal and clones do not interfere with the spread of differentiation-promoting signals. Antennal disc cell fates are also altered.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
The distal leg phenotypes provoked by Cdk8K185, ktoT241 double mutant clones induced specifically in the leg (using Scer\GAL4Dll-em212 and Scer\FLP1Scer\UAS.cUa) are indistinguishable from ktoT241 alone but distinct from Cdk8K185 alone, both for sex comb differentiation and for overall leg structure. The phenotypes of Cdk8K185, ktoT241 double mutant clones induced specifically in the eye (using Scer\FLP1ey.PB) in a Minute background are indiscernible from ktoT241 alone.
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescued by
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (5)