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General Information
Symbol
Dmel\hth100-1
Species
D. melanogaster
Name
FlyBase ID
FBal0121728
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
hth100.1
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

C10533944T

Reported nucleotide change:

C2213T

Amino acid change:

R306term | hth-PA; R321term | hth-PC

Reported amino acid change:

R321term

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

This allele encodes only the 'HDless' (homeodomainless) isoform and does not encode the 'HM' domain.

Amino acid replacement: R321term.

Nucleotide substitution: C2213T.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Loss-of-function hth100-1 eye clones exhibit a dorsal-ventral constraint in their phenotypes, where clones in the ventral eye result in eye enlargement or induction of ectopic eyes, whereas in the dorsal eye these clones do not affect the eye fate.

hth100-1 embryos show head defects. In these embryos, A1 is weakly transformed toward A2, but the rest of the abdominal segments have a wild-type pattern of denticle belts. There are no segmental fusions and the thoracic segments are normal except for the rare appearance of a small number of ectopic denticles.

hth100-1 clones induced in the antennal imaginal disc result in the transformation of the antenna towards a leg. hth100-1 clones induced in the wing result in aberrant morphology of the wing hinge.

In approximately one-third of hth100-1 legs the tibia and femur are partially fused.

Mutant embryos show a relatively mild phenotype in the PNS, which consists mainly of dorsal localisation of LCh5 neurons in some of the abdominal segments.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhancer of
Statement
Reference

hth[+]/hth100-1 is an enhancer of eye | somatic clone phenotype of L2

hth[+]/hth100-1 is an enhancer of eye disc | somatic clone phenotype of L2

Suppressor of
Statement
Reference

hth[+]/hth100-1 is a suppressor of eye | somatic clone phenotype of Lrev6-3

hth[+]/hth100-1 is a suppressor of eye disc | somatic clone phenotype of Lrev6-3

Additional Comments
Genetic Interactions
Statement
Reference

Loss-of-function L2 heterozygous eye clones in a hth100-1 heterozygous background results in a complete loss-of-ventral eye phenotype, as seen in L2 eye clones.

Lrev6-3 heterozygous eye clones in a hth100-1 heterozygous background results in no ventral eye loss and a wild-type eye phenotype.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

hth100-1 and hth100-2 have an identical mutation and are likely to represent a clonal event.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (8)