Expression of edScer\UAS.cBa, under the control of Scer\GAL4twi.PG, in a Gripex36 background, greatly enhances the muscle defects of Gripex36 embryos; ventrolateral muscles are more severely deranged and often appear to adhere to other muscles, whereas lateral transverse muscles split.
The addition of Nrg180.I.Scer\UAS enhances the rough eye phenotype seen in edScer\UAS.cBa, Scer\GAL4GMR.PF animals with a reduction in the number of ommatidia and a decrease in the number of bristles. In addition, a significantly higher percentage of ommatidia contain fewer photoreceptor and cone cells. The addition of Nrgl4/+ significantly suppresses the loss of cone cell phenotype seen in edScer\UAS.cBa, Scer\GAL4GMR.PF animals but has no effect on photoreceptor loss. The addition of Fas1::NrgGPI.Scer\UAS enhances the rough eye phenotype seen in edScer\UAS.cBa, Scer\GAL4GMR.PF.
Ubiquitous expression of edScer\UAS.cBa under the control of Scer\GAL4C-765 rescues the cell sorting phenotypes seen in ed1X5 mutant wing disc clones. The boundary between the clone and the surrounding wild type cells is no longer smooth edged, instead appearing jagged as in wild type. Normal levels of shg are seen.