FlyBase Allele Report: Dmel\dlt[dre1]

General Information

Symbol

Dmel\dlt^dre1

Species

D. melanogaster

Name

FlyBase ID

FBal0121802

Feature type

allele

Associated gene

Dmel\dlt

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Tanentzapf et al., 2000)

Mutagen

Progenitor genotype

Cytology

Description

Amino acid replacement: ?865term.

(Bhat et al., 2003)

Nucleotide substitution: C865T. Introduces a premature stop codon, which results in a truncated protein of 288 amino acids.

(Pielage et al., 2003)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3L:1,792,551..1,792,551 [-]

Nucleotide change:

C1792551T

Reported nucleotide change:

C865T

Amino acid change:

Q289term | dlt-PA

Reported amino acid change:

?289term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Bhat et al., 2003, Pielage et al., 2003)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

embryonic/larval salivary gland | embryonic stage

(Bhat et al., 1999)

eye | somatic clone

(Pielage et al., 2003)

follicle cell | somatic clone

(Tanentzapf et al., 2000)

imaginal disc

(Bhat et al., 1999)

leg

(Bhat et al., 1999)

wing disc | somatic clone

(Pielage et al., 2003)

Detailed Description

Statement

Reference

dlt^dre1 mutant eyes, generated using the Minute technique, can be significantly smaller than wild-type eyes, although this phenotype is extremely variable. BrdU incorporation is still able to occur during eye development, indicating that DNA synthesis during proliferation is not affected. dlt^dre1 cell clones in the eye imaginal disc generated using the FLP/FRT technique are of a similar size to wild-type cells, but these clones can never survive to be found in the adult compound eye. dlt^dre1 FLP/FRT cell clones are also of a similar size to wild-type cells when induced in the wing disc.

(Pielage et al., 2003)

Homozygous follicle cell clones induced before formation of the follicular epithelium show gaps of variable size in the epithelium.

(Tanentzapf et al., 2000)

dlt^dre1/Df(3L)Aprt-126 and dlt^dre1/Df(3L)MY10 animals die as third instar larvae or early pupae which lack imaginal discs. Salivary gland cells have an abnormal, rounded morphology. dlt^dre1/dlt^S059504 animals die as fully developed pupae with leg duplications.

(Bhat et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

dlt⁰⁴²⁷⁶

(Bhat et al., 2003)

dlt^P4

(Pielage et al., 2003)

dlt^P2

(Pielage et al., 2003)

dlt^P1

(Pielage et al., 2003)

dlt^A1

(Pielage et al., 2003)

dlt^S059504

(Bhat et al., 1999)

Rescued by

Df(3L)Aprt-32/dlt^dre1 is rescued by dlt^Ubi-p63E.PP

(Pielage et al., 2003)

Df(3L)MY10/dlt^dre1 is rescued by dlt^Ubi-p63E.PP

(Pielage et al., 2003)

Not rescued by

dlt^dre1 is not rescued by dlt^Ubi-p63E.PP

(Pielage et al., 2003)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Separable from: Patj^dre1.

(Bhat et al., 2003)

Comments

FlyBase curator comment: The "dlt^dre1" allele (FBal0121802) corresponds to either dlt¹ (FBal0009635) or dlt² (FBal0009636) (these 2 alleles were isolated in FBrf0049893), but there is not enough information to know which of the 2 alleles it corresponds to.

(FlyBase, 1992-)

Not rescued by: Patj^EΔHS. Not rescued by: Patj^SΔHS. Partially rescued by: Patj^EHHS. Partially rescued by: Patj^SHS. Rescued by: Patj^+tCOSMY1-1. Rescued by: Patj^+tCOSMY8-1. FlyBase curator comment: Stated partial rescue of dlt^dre1 mutants by Patj constructs is unexplained.

(Bhat et al., 1999)

The P{Patj^EHHS} construct (Figure 4 of FBrf0107610) now fails to rescue dlt^dre1.

(Bhat et al., 2003)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

dlt^dre1

Name Synonyms

Secondary FlyBase IDs

FBal0096992

References (5)

Report Sections

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