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General Information
Symbol
Dmel\cutletunspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0121814
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    Homozygous females have ovaries that rarely form egg chambers (oogenesis is blocked at the germarial stages in most cases). When an egg chamber forms it often has less than the normal complement of 15 nurse cells and 1 oocyte. Wings often have regions missing from the posterior wing margin, as well as the anterior/posterior border. Eyes have irregularly shaped facets and inappropriately positioned bristles. One or more ocellar bristles are often missing. There is a partially penetrant male-sterile phenotype. The R1 and R6 photoreceptor precursor cells are often absent in developing mutant eye imaginal discs. Some ommatidial clusters in pupal eye discs contain fewer than the normal 4 cone cells. Some clusters with extra photoreceptor and cone cells are also seen. Mutant eye discs show a mildly abnormal pattern of BrdU incorporating cells. This is particularly apparent in the second mitotic wave, which is normally a smooth stripe, but is disrupted in mutant discs. The mitotic zones of the eye disc are disrupted in mutants (normally there are 2 zones of mitosis); both zones are expanded and the boundary between the two is obscured. Cell death is increased in mutant eye discs compared to wild type. The apoptotic cells in mutant eye discs are mostly anterior to the morphogenetic furrow, where the majority of cell proliferation occurs.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Phenotype Manifest In
    NOT Enhanced by
    Statement
    Reference

    cutletunspecified has eye phenotype, non-enhanceable by dpaunspecified

    NOT suppressed by
    Statement
    Reference

    cutletunspecified has eye phenotype, non-suppressible by dpaunspecified

    cutletunspecified has eye phenotype, non-suppressible by PCNAunspecified

    Additional Comments
    Genetic Interactions
    Statement
    Reference

    mus209unspecified or dpaunspecified have no modifying effect on the cutletunspecified eye phenotype.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Not rescued by
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (1)
    Reported As
    Symbol Synonym
    cutletunspecified
    Name Synonyms
    Secondary FlyBase IDs
      References (1)