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General Information
Symbol
Dmel\cherEP3715
Species
D. melanogaster
Name
FlyBase ID
FBal0121831
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
EP(3)3715
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

The orientation of the P{EP} element is the same as the direction of cher transcription.

P{EP} insertion in the 5' regulatory region of cher. The P{EP} element is oriented in the same direction as the direction of transcription of cher.

P{EP} insertion 78bp upstream of the 5' end of the cher EST GH12209.

Insertion components
P{EP}cherEP3715
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Ovaries from cherEP3715 females are dramatically reduced in size. and are comprised of short, squat ovarioles that usually appear as a single, distended germarium from which egg chambers fail to emerge. Closer examination these germaria shows that consecutive germline cysts are not properly packaged in follicular monolayers to form discrete egg chambers. In germaria from cherEP3715 homozygous adults, individual sixteen-cell germline cysts appear to form normally and the fusome disappears on schedule. Follicle cells extend projections to surround the germline cells. However, these extensions appear to be delayed since there are many more germline cells between the anterior tip of the germarium and where these extensions form than in wild-type. Migration of follicle cells to form the interfollicular stalk fails to occur. In fact these cells fail to even make the apical contacts that precede this migration. However, follicle cell apicobasal polarity is not directly affected. In addition, germline cells appear loosely packed and individual germ-cells often bulge out from a cyst, sometimes making contact with the basal membrane of the germarium.

The P{EP}cherEP3715 insertion does not disrupt cher function.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
NOT Enhancer of
Suppressor of
Statement
Reference
NOT Suppressor of
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

The notched wing phenotype caused by expression of PsnScer\UAS.cGa under the control of Scer\GAL4ct.PB is suppressed by co-expression of cherEP3715 (under the control of Scer\GAL4ct.PB). The extra scutellar macrochaetae seen when PsnScer\UAS.cGa is expressed under the control of Scer\GAL4pnr-MD237 are suppressed by co-expression of cherEP3715 (under the control of Scer\GAL4pnr-MD237).

Xenogenetic Interactions
Statement
Reference

The rough eye phenotype caused by expression of Hsap\MAPTV337M.Scer\UAS under the control of Scer\GAL4GMR.PF is enhanced by cherEP3715.

Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Precise excision of the P{EP} element reverts the modifying effect of cherEP3715 on the rough eye phenotype caused by expression of Hsap\MAPTV337M.Scer\UAS under the control of Scer\GAL4GMR.PF.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
Reported As
Symbol Synonym
cherEP(3)3175
cherEP(3)3715
cherEP3175
cherEP3715
Name Synonyms
Secondary FlyBase IDs
  • FBal0101478
References (7)