Allele Dmel\Pten^unspecified

General Information
Symbol	Dmel\Pten^unspecified	Species	D. melanogaster
Name		FlyBase ID	FBal0122010
Feature type	allele	Associated gene	Dmel\Pten

Allele class
Mutagen
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| larval stage \| recessive (Stocker et al., 2002) visible \| somatic clone (Menut et al., 2007)
Phenotype Manifest In
	eye \| somatic clone (Menut et al., 2007) wing disc (Tang et al., 2001)
Detailed Description
	Statement Reference Animals containing mutant eye discs generated using the eyFLP-cell lethal system eclose, and have reduced eyes. (Menut et al., 2007) Wing disc cells are larger than normal in mutants. (Tang et al., 2001)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement Reference Pten^unspecified has lethal \| recessive \| larval stage phenotype, suppressible by Akt1¹/Akt1³ (Stocker et al., 2002) Pten^unspecified has lethal \| recessive \| larval stage phenotype, suppressible by Akt1³/Akt1³ (Stocker et al., 2002) Pten^unspecified has lethal \| recessive \| larval stage phenotype, suppressible by Akt1⁰⁴²²⁶/Akt1⁰⁴²²⁶/Akt1³ (Stocker et al., 2002)
NOT suppressed by
Statement Reference Pten^unspecified has lethal \| recessive \| larval stage phenotype, non-suppressible by Akt1¹ (Stocker et al., 2002) Pten^unspecified has lethal \| recessive \| larval stage phenotype, non-suppressible by Akt1⁰⁴²²⁶/Akt1⁰⁴²²⁶ (Stocker et al., 2002)
NOT Enhancer of
Statement Reference Pten^unspecified/Pten[+] is a non-enhancer of visible phenotype of Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}, Scer\GAL4^Bx-MS1096 (Coelho et al., 2005)
NOT Suppressor of
Statement Reference Pten^unspecified/Pten[+] is a non-suppressor of visible phenotype of Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}, Scer\GAL4^Bx-MS1096 (Coelho et al., 2005)
Other
Statement Reference Akt1³, Pten^unspecified has large body phenotype (Stocker et al., 2002, Stocker et al., 2002) Akt1⁰⁴²²⁶, Akt1⁰⁴²²⁶, Akt1³, Pten^unspecified has large body phenotype (Stocker et al., 2002, Stocker et al., 2002)
Phenotype Manifest In
NOT Enhancer of
Statement Reference Pten^unspecified/Pten[+] is a non-enhancer of wing phenotype of Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}, Scer\GAL4^Bx-MS1096 (Coelho et al., 2005)
NOT Suppressor of
Statement Reference Pten^unspecified/Pten[+] is a non-suppressor of wing phenotype of Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}, Scer\GAL4^Bx-MS1096 (Coelho et al., 2005)
Other
Statement Reference Pten^unspecified, lilli^unspecified has ommatidium phenotype (Tang et al., 2001, Tang et al., 2001)
Additional Comments
Genetic Interactions
Statement Reference Pten^unspecified flies rescued by the combination Akt1¹/Akt1³ are wild-type in size. Pten^unspecified ; Akt1¹/Akt1³ flies have essentially normal ommatidia and rhabdomeres in the eye and the wings show normal venation. (Stocker et al., 2002) Wing disc cells doubly mutant for lilli and Pten enlarge to the same extent as Pten single mutant cells. Ommatidia of this genotype are disorganised. (Tang et al., 2001)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Pten^unspecified
Name Synonym
Secondary FlyBase IDs

References ( 4 )
Research paper	Menut et al., 2007, Genetics 177(3): 1667--1677 A mosaic genetic screen for Drosophila neoplastic tumor suppressor genes based on defective pupation. [FBrf0202932] Coelho et al., 2005, Genetics 171(2): 597--614 A genetic screen for dominant modifiers of a small-wing phenotype in Drosophila melanogaster identifies proteins involved in splicing and translation. [FBrf0190712] Stocker et al., 2002, Science 295(5562): 2088--2091 Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB. [FBrf0151483] Tang et al., 2001, Development 128(5): 801--813 Transcriptional regulation of cytoskeletal functions and segmentation by a novel maternal pair-rule gene, lilliputian. [FBrf0134581]

Allele Dmel\Ptenunspecified

Allele Dmel\Pten^unspecified