Allele Dmel\JIL-1^z60

General Information
Symbol	Dmel\JIL-1^z60	Species	D. melanogaster
Name		FlyBase ID	FBal0122075
Feature type	allele	Associated gene	Dmel\JIL-1

Allele class	loss of function allele, hypomorphic allele - genetic evidence
Mutagen	Delta2-3, P-element activity
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class	hypomorphic allele - genetic evidence (Lerach et al., 2006) loss of function allele (Zhang et al., 2006)
Mutagen	Delta2-3 (Wang et al., 2001) P-element activity (Zhang et al., 2003)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	JIL-1^EP3657 (Wang et al., 2001) P{EP}JIL-1^EP3657 (Zhang et al., 2003)
Nature of the lesion	Statement Reference Imprecise excision which leaves the P{EP} promoter region intact but removes the entire JIL-1 promoter and the 5' untranslated region. Proximal genomic sequences upstream of JIL-1, extending to a region between nucleotides 207,742 and 269,371 of AE003546 (release 3.0, GI:23093654) are also removed, resulting in the complete deletion of the CG6279 coding sequence. (Zhang et al., 2003) Imprecise excision of the P{EP} element (the 5' end has been excised), removing a portion of the JIL-1 sequence (the 5' untranslated sequence and putative promoter region). (Wang et al., 2001)
Caused by insertion	P{3'EP}JIL-1^z60 (Wang et al., 2001, Zhang et al., 2006, Zhang et al., 2003)
Caused by aberration	Df(3L)JIL-1^z60 (Zhang et al., 2003)
Cytology
Phenotypic Data
Phenotypic Class
	enhancer of variegation, with P{hsp26-pt-T}39C-3 (Bao et al., 2007) enhancer of variegation, with P{hsp26-pt-T}118E-10 (Bao et al., 2007) enhancer of variegation, with P{hsp26-pt-T}118E-25 (Bao et al., 2007) enhancer of variegation, with P{hsp26-pt-T}118E-32 (Bao et al., 2007) enhancer of variegation (with JIL-1^z2), with P{hsp26-pt-T}39C-3 (Bao et al., 2007) enhancer of variegation (with JIL-1^z2), with P{hsp26-pt-T}118E-10 (Bao et al., 2007) enhancer of variegation (with JIL-1^z2), with P{hsp26-pt-T}118E-25 (Bao et al., 2007) enhancer of variegation (with JIL-1^z2), with P{hsp26-pt-T}118E-32 (Bao et al., 2007) lethal (with JIL-1^z2) (Zhang et al., 2006) lethal \| recessive (Wang et al., 2001, Wang et al., 2001) partially lethal - majority die (with JIL-1^z2) (Lerach et al., 2006, Bao et al., 2007) suppressor of variegation, with In(1)w^m4 (Lerach et al., 2006) suppressor of variegation (with JIL-1^z2), with In(1)w^m4 (Lerach et al., 2006)
Phenotype Manifest In
	polytene chromosome (Wang et al., 2001)
Detailed Description
	Statement Reference Only 1 out of 871 JIL-1^z2/JIL-1^z60 flies eclose. (Zhang et al., 2006) Eclosion rate is less than 3%. (Wang et al., 2001) Homozygous larvae have an eclosion rate of 0.5%. The number of males eclosing is 32% that of females. The polytene chromosome banding pattern is perturbed in homozygous third instar larvae. Perturbation of the male X chromosome is relatively more severe than that of the autosomes. (Wang et al., 2001)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement Reference JIL-1^z60/JIL-1^z2 has lethal phenotype, suppressible \| partially by Su(var)3-9¹/Su(var)3-9[+] (Zhang et al., 2006)
Suppressor of
Statement Reference JIL-1^z60/JIL-1^z60 is a suppressor \| partially of enhancer of variegation \| dominant phenotype of E(var)2-1¹, In(1)w^m4 (Lerach et al., 2006, Lerach et al., 2006)
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference JIL-1^z2/JIL-1^z60 flies that have one copy of the Su(var)3-9¹ allele show greater levels of survival compared to those that carry two wild-type copies of Su(var)3-9. (Zhang et al., 2006)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

Comments
	General trend from least to most viable is: JIL-1^z2 < JIL-1^h9 < JIL-1^z60 < JIL-1^EP3657 < JIL-1^z28 ~ JIL-1^Scim. (Zhang et al., 2003)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	JIL-1^Z60 JIL-1^z60 (Lerach et al., 2006, Bao et al., 2007)
Name Synonym
Secondary FlyBase IDs

References ( 6 )
Research paper	Bao et al., 2007, Genetics 176(2): 1355--1358 Loss-of-function alleles of the JIL-1 histone H3S10 kinase enhance position-effect variegation at pericentric sites in Drosophila heterochromatin. [FBrf0202093] Lerach et al., 2006, Genetics 173(4): 2403--2406 Loss-of-function alleles of the JIL-1 kinase are strong suppressors of position effect variegation of the wm4 allele in Drosophila. [FBrf0192731] Zhang et al., 2006, Development 133(2): 229--235 The JIL-1 histone H3S10 kinase regulates dimethyl H3K9 modifications and heterochromatic spreading in Drosophila. [FBrf0190333] Zhang et al., 2003, Genetics 165(3): 1341--1354 Genetic and phenotypic analysis of alleles of the Drosophila chromosomal JIL-1 kinase reveals a functional requirement at multiple developmental stages. [FBrf0167636] Wang et al., 2001, Cell 105(4): 433--443 The JIL-1 tandem kinase mediates histone H3 phosphorylation and is required for maintenance of chromatin structure in Drosophila. [FBrf0136815]
Abstract	Wang et al., 2001, A. Dros. Res. Conf. 42: 38 JIL-1, a putative chromosomal histone H3 kinase, is required for maintenance of chromatin structure. [FBrf0133755]

Allele Dmel\JIL-1z60

Allele Dmel\JIL-1^z60