Allele Dmel\tutl⁴

General Information
Symbol	Dmel\tutl⁴	Species	D. melanogaster
Name		FlyBase ID	FBal0122876
Feature type	allele	Associated gene	Dmel\tutl

Allele class	loss of function allele
Mutagen	Delta2-3
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	loss of function allele (Bodily et al., 2001)
Mutagen	Delta2-3 (Bodily et al., 2001)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	tutl^k14703 (Bodily et al., 2001)
Nature of the lesion	Statement Reference Imprecise excision of the P{lacW} element resulting in deletion of tutl sequences. The deletion extends into CG16857. (Bodily et al., 2001)
Caused by aberration	Df(2L)tutl⁴ (Bodily et al., 2001)
Cytology
Phenotypic Data
Phenotypic Class
	behavior defective \| larval stage (with Df(2L)ed-dp) (Bodily et al., 2001) behavior defective \| larval stage \| recessive (Bodily et al., 2001) lethal \| recessive (Bodily et al., 2001) locomotor behavior defective \| larval stage \| recessive (Bodily et al., 2001)
Phenotype Manifest In

Detailed Description
	Statement Reference Lethal stage is during pre-eclosion. General morphology of the mutant larvae is normal. Mutant larvae respond to tactile stimulation at their anterior end by contracting at both ends and rocking back and forth in place. After a few seconds of this behaviour, the larvae cease this abnormal movement and return to a normal forward-crawling motion. This contrasts with wild-type larvae which respond by showing a characteristic escape behaviour of 1-3 reverse peristaltic movements followed by a lateral turning behaviour. Homozygous and tutl⁴/Df(2L)ed-dp larvae have a severely compromised ability to roll over from an inverted position; the time required to right themselves is significantly (nearly 20-fold) longer than control larvae. The rate of executing peristaltic contractions during normal locomotion is slightly reduced (less than 15%) in homozygous larvae compared to wild type. Homozygous embryos show no abnormalities in the morphology of the longitudinal tracts or the anterior and posterior commissures. No transient defects in axonal patterning have been detected through stages 9 to 17. Brain morphology and size and shape of the axon scaffold appears normal. No abnormalities in the Fas2-positive longitudinal connectives or in the motor axon pathways that exit the CNS to innervate the musculature are seen. The ventral unpaired median axons and segmental and intersegmental nerves also appear normal. No defects in the PNS have been detected. The longitudinal connectives appear normal in third instar mutant larvae. Muscle innervation and presynaptic morphology at the neuromuscular junction (NMJ) appears normal. The kinetics and amplitude of the excitatory junctional currents (EJCs) at the NMJ are not significantly different from wild type. (Bodily et al., 2001)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	tutl4 (Bodily et al., 2001) tutl⁴ (Al-Anzi and Wyman, 2009)
Name Synonym
Secondary FlyBase IDs

References ( 2 )
Research paper	Al-Anzi and Wyman, 2009, Neural Dev. 4: 31 The Drosophila immunoglobulin gene turtle encodes guidance molecules involved in axon pathfinding. [FBrf0209104] Bodily et al., 2001, J. Neurosci. 21(9): 3113--3125 A novel member of the Ig superfamily, turtle, is a CNS-specific protein required for coordinated motor control. [FBrf0135975]

Allele Dmel\tutl4

Allele Dmel\tutl⁴