Allele Dmel\msk⁴

General Information
Symbol	Dmel\msk⁴	Species	D. melanogaster
Name		FlyBase ID	FBal0122949
Feature type	allele	Associated gene	Dmel\msk

Map ( GBrowse )
Allele class
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	ethyl methanesulfonate (Baker et al., 2002)
Mutations Mapped to the Genome

Type Location Additional Notes References point mutation 3L:8,111,372..8,111,372 evidence=experimental pr_change=R314@\|msk-PA reported_na_change=C940T reported_pr_change=R314@ na_change=C8111372T (Baker et al., 2002)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Nucleotide substitution: C940T. Amino acid replacement: R314@. (Baker et al., 2002) Amino acid replacement: ??@. (Lorenzen et al., 2001)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| embryonic stage \| recessive (Baker et al., 2002) lethal \| larval stage \| recessive (Baker et al., 2002) lethal \| recessive (Lorenzen et al., 2001)
Phenotype Manifest In

Detailed Description
	Statement Reference Homozygotes die as late embryos or early larvae, with a normal looking cuticle. (Baker et al., 2002) Lethality acts in the late embryo or early larval stages. Embryos are morphologically wild type. (Lorenzen et al., 2001)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement Reference msk⁴ is an enhancer of visible phenotype of rho^Stg (Baker et al., 2002) msk⁴ is an enhancer of visible phenotype of rho^Wk (Baker et al., 2002)
Suppressor of
Statement Reference msk⁴/msk[+] is a suppressor of visible phenotype of Scer\GAL4^c684, if^m8.Scer\UAS (Baker et al., 2002) msk⁴ is a suppressor \| partially of visible phenotype of if^m8.αTub84B (Baker et al., 2002)
NOT Suppressor of
Statement Reference msk⁴ is a non-suppressor of visible phenotype of Egfr^E1 (Baker et al., 2002) msk⁴ is a non-suppressor of visible phenotype of rl^Sem (Baker et al., 2002)
Phenotype Manifest In
Enhancer of
Statement Reference msk⁴ is an enhancer of wing phenotype of rho^Stg (Baker et al., 2002) msk⁴ is an enhancer of wing vein \| ectopic phenotype of rho^Wk (Baker et al., 2002)
Suppressor of
Statement Reference msk⁴/msk[+] is a suppressor of wing phenotype of Scer\GAL4^c684, if^m8.Scer\UAS (Baker et al., 2002) msk⁴ is a suppressor \| partially of wing phenotype of if^m8.αTub84B (Baker et al., 2002) msk⁴ is a suppressor of eye phenotype of Scer\GAL4^lz-gal4, sens^Scer\UAS.cNa (Pepple et al., 2007)
NOT Suppressor of
Statement Reference msk⁴ is a non-suppressor of wing vein \| ectopic phenotype of Egfr^E1 (Baker et al., 2002) msk⁴ is a non-suppressor of wing vein \| ectopic phenotype of rl^Sem (Baker et al., 2002)
Additional Comments
Genetic Interactions
Statement Reference The wing blistering caused by expression of if^m8.αTub84B is suppressed by msk⁴/+. The wing blistering caused by expression of if^m8.Scer\UAS under the control of Scer\GAL4^337Y is suppressed by msk⁴/+. (Baker et al., 2002)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer
	Selected as: a dominant suppressor of the wing blister phenotype caused by if^m8.Scer\UAS expressed under the control of Scer\GAL4^c684. (Baker et al., 2002)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	msk⁴ (Pepple et al., 2007)
Name Synonym
Secondary FlyBase IDs

References ( 3 )
Research paper	Pepple et al., 2007, Genetics 175(1): 125--141 A genetic screen in Drosophila for genes interacting with senseless during neuronal development identifies the importin moleskin. [FBrf0194654] Baker et al., 2002, Genetics 162(1): 285--296 Genetic interaction between integrins and moleskin, a gene encoding a Drosophila homolog of importin-7. [FBrf0152039] Lorenzen et al., 2001, Development 128(8): 1403--1414 Nuclear import of activated D-ERK by DIM-7, an importin family member encoded by the gene moleskin. [FBrf0134569]

Allele Dmel\msk4

Allele Dmel\msk⁴