FlyBase Allele Report: Dmel\gwl[EP515]

General Information

Symbol

Dmel\gwl^EP515

Species

D. melanogaster

Name

FlyBase ID

FBal0123126

Feature type

allele

Associated gene

Dmel\gwl

Associated Insertion(s)

P{EP}gwl^EP515

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Gene Disruption Project members, 2001-, Kraut et al., 2001, Kraut et al., 2001)

Progenitor genotype

Associated Insertion(s)

P{EP}gwl^EP515

Cytology

Description

P{EP}gwl^EP515 is inserted 217bp 5' of gwl and 12bp 5' of CG7718.

(Archambault et al., 2007)

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3R:18,746,053..18,746,053 [+]

(Zhan et al., 2013, Archambault et al., 2007, Gene Disruption Project members, 2001-, Kraut et al., 2001, Kraut et al., 2001)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | larval stage, with Scer\GAL4^elav-C155

(Kraut et al., 2001)

Phenotype Manifest In

anterior fascicle & synapse, with Scer\GAL4^elav-C155

(Kraut et al., 2001)

anterior fascicle & synapse | supernumerary, with Scer\GAL4^elav-C155

(Kraut et al., 2001)

larval intersegmental nerve, with Scer\GAL4^elav-C155

(Kraut et al., 2001)

Detailed Description

Statement

Reference

In mutant larvae expressing gwl^EP515 under the control of Scer\GAL4^elav-C155 ISN pathfinding defects can be seen. ISNb is split into two tracts that leave the ISN at different points. One of these innervates muscles 12 and 13, while the other appears to innervate 6/7 and other muscles. ISNd, which is normally linear is also split into a spray of branches. Mutant larvae expressing gwl^EP515 under the control of Scer\GAL4^elav-C155 have ISN neuron pathfinding defects. Mutant larvae expressing gwl^EP515 under the control of Scer\GAL4^elav-C155 have excessive or ectopic synapses. Mutant larvae expressing gwl^EP515 under the control of Scer\GAL4^elav-C155 have reduced or abnormal synapses.

(Kraut et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Suppressor of

Statement

Reference

gwl^EP515, Scer\GAL4^Toll-6-D42 is a non-suppressor of short lived phenotype of Hsap\TARDBP^UAS.cHa, Scer\GAL4^Toll-6-D42

(Zhan et al., 2013)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

17174

w¹¹¹⁸; P{EP}gwl^EP515/TM6B, Tb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Pk91C^EP515

(Kraut et al., 2001, Kraut et al., 2001)

gwl^EP515

Name Synonyms

greatwallEP515

(Zhan et al., 2013)

Secondary FlyBase IDs

References (5)

Report Sections

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