FB2025_01 , released February 20, 2025
Allele: Hsap\SMAD1UAS.cMa
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General Information
Symbol
Hsap\SMAD1UAS.cMa
Species
H. sapiens
Name
Saccharomyces cerevisiae UAS construct a of Marquez
FlyBase ID
FBal0123158
Feature type
allele
Associated gene
Hsap\SMAD1
Associated Insertion(s)
Carried in Construct
P{UAS-MADH1.M}
Key Links
Transgenic product class
wild_type
(Marquez et al., 2001)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Marquez et al., 2001)
Mutagen
in vitro construct
(Marquez et al., 2001)
Progenitor genotype
Carried in construct
P{UAS-MADH1.M}
Cytology
Description

Expression of v is governed by UASt regulatory sequences.

(Marquez et al., 2001)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hsap\SMAD1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      When expression is driven by Scer\GAL4ptc-559.1, ectopic vein tissue appears between wing veins L3 and L5. The distance between L3 and L5 appears reduced. Wings are 15% smaller than wild type. An ectopic leg develops on the ventral side of the normal limb. The ectopic leg has one segment.

      (Marquez et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Co-expression of Hsap\MADH1Scer\UAS.cMa can rescue the wing size and vein development defects caused by Scer\GAL4Bx-MS1096-KE-driven expression of MaddsRNA.Scer\UAS.cEa.

      Hsap\MADH1Scer\UAS.cMa can rescue the lethality of Scer\GAL4da.G32-driven MaddsRNA.Scer\UAS.cEa expression.

      (Eivers et al., 2009)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Hsap\MADH1Scer\UAS.cMa
      Hsap\SMAD1Scer\UAS.cMa
      Hsap\SMAD1UAS.cMa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Marquez
      (Marquez et al., 2001)
      Secondary FlyBase IDs
        References (2)