FlyBase Allele Report: Dmel\Atg2[EP3697]

General Information

Symbol

Dmel\Atg2^EP3697

Species

D. melanogaster

Name

FlyBase ID

FBal0123243

Feature type

allele

Associated gene

Dmel\Atg2

Associated Insertion(s)

P{EP}Atg2^EP3697

Carried in Construct

Also Known As

Atg2[EP3697]

Key Links

Genomic Maps

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Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Gene Disruption Project members, 2001-, Kraut et al., 2001)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

transposable_element_insertion_site

3L:2,774,375..2,774,375 [+]

(Cunningham et al., 2020, Nagy et al., 2015, Pircs et al., 2012, Tian et al., 2011, Shen and Ganetzky, 2009, Scott et al., 2004, Gene Disruption Project members, 2001-, Kraut et al., 2001)

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Cytology

Nature of the lesion

Statement

Reference

Insertion components

P{EP}Atg2^EP3697

Product class / Tool use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

misexpression element

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy

(Shen and Ganetzky, 2009)

abnormal neuroanatomy | larval stage, with Scer\GAL4^elav-C155

(Kraut et al., 2001)

lethal - all die before end of larval stage | recessive, with Scer\GAL4^- :

(Scott et al., 2004)

some die during larval stage | recessive, with Scer\GAL4^- :

(Scott et al., 2004)

Phenotype Manifest In

anterior fascicle & synapse, with Scer\GAL4^elav-C155

(Kraut et al., 2001)

embryonic/larval fat body | third instar larval stage (with Df(3L)BSC119)

(Pircs et al., 2012)

embryonic/larval midgut | P-stage (with Df(3L)Exel6091)

(Denton et al., 2009)

larval intersegmental nerve, with Scer\GAL4^elav-C155

(Kraut et al., 2001)

neuromuscular junction

(Shen and Ganetzky, 2009)

NMJ bouton

(Shen and Ganetzky, 2009)

Detailed Description

Statement

Reference

Atg2^EP3697/Df(3L)BSC119 mutants display basal autophagy defects in larval fat body cells.

(Pircs et al., 2012)

Atg2^EP3697 heterozygous neuromuscular junctions exhibit wild-type bouton levels.

(Tian et al., 2011)

Atg2^EP3697/Df(3L)Exel6091 animals analysed at +4 hours relative to puparium formation show a significant delay in midgut histolysis compared to controls. At +12 hours relative to puparium formation, larval midgut contraction is dramatically delayed in the mutants compared to controls.

(Denton et al., 2009)

Atg2^EP3697 mutants exhibit neuromuscular junction undergrowth but do not exhibit defects in axonal transport.

(Shen and Ganetzky, 2009)

Mutants show disruption of autophagy.

(Scott et al., 2004)

Mutant larvae expressing Atg2^EP3697 under the control of Scer\GAL4^elav-C155 have reduced or abnormal synapses. Mutant larvae expressing Atg2^EP3697 under the control of Scer\GAL4^elav-C155 have ISN neuron pathfinding defects.

(Kraut et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Atg2^EP3697 is an enhancer of abnormal neuroanatomy phenotype of Scer\GAL4^elav-C155, hiw^UAS.fl

(Shen and Ganetzky, 2009)

Atg2^EP3697 is an enhancer of decreased cell growth phenotype of Scer\GAL4^elav-C155, hiw^UAS.fl

(Shen and Ganetzky, 2009)

Suppressor of

Statement

Reference

Atg2[+], mask^UAS.cZa, Atg2^EP3697, Scer\GAL4^how-24B is a suppressor | partially of lethal - all die before end of P-stage | heat sensitive phenotype of Prosβ6^1.B.UAS, Scer\GAL4^how-24B

(Zhu et al., 2017)

Atg2^EP3697, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF is a suppressor of visible phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299

(Simonsen et al., 2007)

NOT Suppressor of

Statement

Reference

Atg2[+], mask^UAS.cZa, Atg2^EP3697, Scer\GAL4^GMR.PU is a non-suppressor of visible | adult stage phenotype of Hsap\MAPT^UAS.GFP, Scer\GAL4^GMR.PU

(Zhu et al., 2017)

Phenotype Manifest In

Enhancer of

Statement

Reference

Atg2^EP3697 is an enhancer of neuromuscular junction phenotype of Scer\GAL4^elav-C155, hiw^UAS.fl

(Shen and Ganetzky, 2009)

Suppressor of

Statement

Reference

Atg2[+], mask^UAS.cZa, Atg2^EP3697, Scer\GAL4^how-24B is a suppressor | partially of pupal thorax | heat sensitive phenotype of Prosβ6^1.B.UAS, Scer\GAL4^how-24B

(Zhu et al., 2017)

Atg2[+]/Atg2^EP3697 is a suppressor of synapse phenotype of Rae1^EX28

(Tian et al., 2011)

Atg2[+]/Atg2^EP3697 is a suppressor of NMJ bouton phenotype of Rae1^EX28

(Tian et al., 2011)

Atg2^EP3697, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF is a suppressor of eye phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299

(Simonsen et al., 2007)

NOT Suppressor of

Statement

Reference

Atg2[+], mask^UAS.cZa, Atg2^EP3697, Scer\GAL4^GMR.PU is a non-suppressor of eye phenotype of Hsap\MAPT^UAS.GFP, Scer\GAL4^GMR.PU

(Zhu et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

An Atg2^EP3697 heterozygous background dominantly suppresses the increase in bouton number seen in Rae1^EX28 homozygous mutant neuromuscular junction.

(Tian et al., 2011)

The modest neuromuscular undergrowth seen upon expression of hiw^Scer\UAS.fl under the control of Scer\GAL4^elav-C155 is enhanced in a Atg2^EP3697 heterozygous background.

(Shen and Ganetzky, 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

17156

w¹¹¹⁸; P{EP}Atg2^EP3697/TM6B, Tb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Atg2^EP3697

(Csizmadia et al., 2018, Nagy et al., 2014, Chang et al., 2013, Tian et al., 2011, Denton et al., 2009)

Atg2[EP3697]

(Nagy et al., 2015, Takáts et al., 2013)

EP3697^EP3697

(Kraut et al., 2001)

atg2^EP3697

(Zhu et al., 2017, Shen and Ganetzky, 2009, Simonsen et al., 2007)

Name Synonyms

Secondary FlyBase IDs

References (15)

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