anterior fascicle & synapse, with Scer\GAL4elav-C155
Atg2EP3697/Df(3L)BSC119 mutants display basal autophagy defects in larval fat body cells.
Atg2EP3697 heterozygous neuromuscular junctions exhibit wild-type bouton levels.
Atg2EP3697/Df(3L)Exel6091 animals analysed at +4 hours relative to puparium formation show a significant delay in midgut histolysis compared to controls. At +12 hours relative to puparium formation, larval midgut contraction is dramatically delayed in the mutants compared to controls.
Atg2EP3697 mutants exhibit neuromuscular junction undergrowth but do not exhibit defects in axonal transport.
Mutants show disruption of autophagy.
Mutant larvae expressing Atg2EP3697 under the control of Scer\GAL4elav-C155 have reduced or abnormal synapses. Mutant larvae expressing Atg2EP3697 under the control of Scer\GAL4elav-C155 have ISN neuron pathfinding defects.
Atg2EP3697 is an enhancer of abnormal neuroanatomy phenotype of Scer\GAL4elav-C155, hiwUAS.fl
Atg2EP3697 is an enhancer of decreased cell growth phenotype of Scer\GAL4elav-C155, hiwUAS.fl
Atg2[+], maskUAS.cZa, Atg2EP3697, Scer\GAL4how-24B is a suppressor | partially of lethal - all die before end of P-stage | heat sensitive phenotype of Prosβ61.B.UAS, Scer\GAL4how-24B
Atg2EP3697, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF is a suppressor of visible phenotype of Scer\GAL4GMR.PF/Scer\GAL4GMR.PF, bchsEP2299
Atg2[+], maskUAS.cZa, Atg2EP3697, Scer\GAL4GMR.PU is a non-suppressor of visible | adult stage phenotype of Hsap\MAPTUAS.GFP, Scer\GAL4GMR.PU
Atg2EP3697 is an enhancer of neuromuscular junction phenotype of Scer\GAL4elav-C155, hiwUAS.fl
Atg2[+], maskUAS.cZa, Atg2EP3697, Scer\GAL4how-24B is a suppressor | partially of pupal thorax | heat sensitive phenotype of Prosβ61.B.UAS, Scer\GAL4how-24B
Atg2[+]/Atg2EP3697 is a suppressor of synapse phenotype of Rae1EX28
Atg2[+]/Atg2EP3697 is a suppressor of NMJ bouton phenotype of Rae1EX28
Atg2EP3697, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF is a suppressor of eye phenotype of Scer\GAL4GMR.PF/Scer\GAL4GMR.PF, bchsEP2299
Atg2[+], maskUAS.cZa, Atg2EP3697, Scer\GAL4GMR.PU is a non-suppressor of eye phenotype of Hsap\MAPTUAS.GFP, Scer\GAL4GMR.PU
An Atg2EP3697 heterozygous background dominantly suppresses the increase in bouton number seen in Rae1EX28 homozygous mutant neuromuscular junction.
The modest neuromuscular undergrowth seen upon expression of hiwScer\UAS.fl under the control of Scer\GAL4elav-C155 is enhanced in a Atg2EP3697 heterozygous background.