Open Close
General Information
Symbol
Dmel\Atg2EP3697
Species
D. melanogaster
Name
FlyBase ID
FBal0123243
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
Atg2[EP3697]
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Insertion components
P{EP}Atg2EP3697
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Atg2EP3697/Df(3L)BSC119 mutants display basal autophagy defects in larval fat body cells.

Atg2EP3697 heterozygous neuromuscular junctions exhibit wild-type bouton levels.

Atg2EP3697/Df(3L)Exel6091 animals analysed at +4 hours relative to puparium formation show a significant delay in midgut histolysis compared to controls. At +12 hours relative to puparium formation, larval midgut contraction is dramatically delayed in the mutants compared to controls.

Atg2EP3697 mutants exhibit neuromuscular junction undergrowth but do not exhibit defects in axonal transport.

Mutants show disruption of autophagy.

Mutant larvae expressing Atg2EP3697 under the control of Scer\GAL4elav-C155 have reduced or abnormal synapses. Mutant larvae expressing Atg2EP3697 under the control of Scer\GAL4elav-C155 have ISN neuron pathfinding defects.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Suppressor of
NOT Suppressor of
Statement
Reference
Phenotype Manifest In
Enhancer of
Statement
Reference
Suppressor of
Statement
Reference

Atg2[+], maskUAS.cZa, Atg2EP3697, Scer\GAL4how-24B is a suppressor | partially of pupal thorax | heat sensitive phenotype of Prosβ61.B.UAS, Scer\GAL4how-24B

Atg2[+]/Atg2EP3697 is a suppressor of synapse phenotype of Rae1EX28

Atg2[+]/Atg2EP3697 is a suppressor of NMJ bouton phenotype of Rae1EX28

NOT Suppressor of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

An Atg2EP3697 heterozygous background dominantly suppresses the increase in bouton number seen in Rae1EX28 homozygous mutant neuromuscular junction.

The modest neuromuscular undergrowth seen upon expression of hiwScer\UAS.fl under the control of Scer\GAL4elav-C155 is enhanced in a Atg2EP3697 heterozygous background.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
References (14)