A Database of Drosophila Genes & Genomes

FB2013_03, released May 7th, 2013
 

Allele Dmel\Cdc42L89.Scer\UAS

General Information
SymbolDmel\Cdc42L89.Scer\UASSpeciesD. melanogaster
NameFlyBase IDFBal0123294
Feature typealleleAssociated geneDmel\Cdc42
Allele class
Mutagenin vitro construct - regulatory fusion
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Description
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FB2013_03
FB2013_02
All updates Click here to see a list of all updates to this record from FB2010_08 and on.
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Allele class
Mutagen
Mutations Mapped to the Genome
Type
Location
Additional Notes
References
Associated Sequence Data
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
Progenitor genotype
Nature of the lesion
Statement
Reference
Amino acid replacement: S89L.
Construct: A dominant negative form of Cdc42 is expressed under the control of Scer\UAS regulatory sequences.
Carried in construct
Cytology
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Statement
Reference
Expression of Cdc42L89.Scer\UAS driven by Scer\GAL4ptc-559.1 results in loss or stunting of epidermal hairs. When Cdc42L89.Scer\UAS is driven by Scer\GAL4Bx-MS1096, occasional multiple (but still stunted) wing hairs are seen. A reduction in wing size, formation of ectopic vein tissue and wing margin phenotypes. A strong bristle loss phenotype is seen in the wing margin which precludes observation of the width of the margin stripe. Small outgrowths in the wing surface are also seen.
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hide Stocks ( 2 )
Bloomington
Kyoto
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Reported As
Symbol Synonym
Cdc42L89.Scer\UAS
 
Name Synonym
Secondary FlyBase IDs
hide References ( 3 )
Research paper
Zhu et al., 2005, Genetics 170(2): 767--777
A screen for genes that influence fibroblast growth factor signal transduction in Drosophila. [FBrf0187664]
Baron et al., 2000, Mol. Gen. Genet. 264(1-2): 98--104
Multiple roles of the Dcdc42 GTPase during wing development in Drosophila melanogaster. [FBrf0129723]
Personal communication to FlyBase
Luo, 2001.5.2, Luo constructs and insertions.
Luo constructs and insertions. [FBrf0136038]