Allele Dmel\TfAP-2⁴

General Information
Symbol	Dmel\TfAP-2⁴	Species	D. melanogaster
Name		FlyBase ID	FBal0123330
Feature type	allele	Associated gene	Dmel\TfAP-2

Map ( GBrowse )
Allele class	amorphic allele - genetic evidence
Mutagen	ethyl methanesulfonate
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	amorphic allele - genetic evidence (Monge et al., 2001)
Mutagen	ethyl methanesulfonate (Monge et al., 2001)
Mutations Mapped to the Genome

Type Location Additional Notes References point mutation 3L:21,605,260..21,605,260 evidence=experimental pr_change=S273F\|AP-2-PA,S277F\|AP-2-PB reported_na_change=C?T reported_pr_change=S273F na_change=C21605260T (Monge et al., 2001)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: S273F. Nucleotide substitution: C?T. (Monge et al., 2001)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| adult stage \| recessive (Monge et al., 2001) visible \| dominant (Monge et al., 2001)
Phenotype Manifest In
	adult head (Monge et al., 2001) joint (Monge et al., 2001) labellum (Monge et al., 2001) leg (Monge et al., 2001) proboscis (Monge et al., 2001) pseudotracheal sensillum (Monge et al., 2001)
Detailed Description
	Statement Reference Pharate pupae and the few eclosing adults show a short leg phenotype. Leg length = 30% wild type. Tarsal joints are lacking. Legs are non-functional. The proximodistal order of segments is not grossly affected as landmarks for the coxa, femur, tibia, and first and last (5th) tarsal segments (sex comb and claws, respectively) are present in the correct order. Rows of misoriented sensory bristles indicate that proximodistal polarity is locally perturbed. The stunted legs show no nervous activity except for a faint twitching of the claws and of cuticle over the femur-tibia junction. Allele has a null phenotype when hemizygous but weak or moderate dominant effect when paired with wild type or hypomorphic alleles. The proboscis is reduced in length and width. Null mutants show a substantial reduction in length and width of the labellum and number of pseudo tracheal rows. The prestomal cavity is present and newly eclosed adults can drink. Clypeus, maxillary palps and antennae are apparently normal but there is increased spacing between antennae. Legs of AP-2⁴/+ are slightly shorter than those of AP-2^-/+. When transherozygous with hypomorphic alleles there is a significant reduction in leg length as compared to that of the hypomorphic allele alone. (Monge et al., 2001)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 1 )
Bloomington	23716 y¹ w^*; P{Car20y}73C TfAP-2⁴ P{neoFRT}80B/TM3, P{sE-raf^torY9}3, Sb¹
Notes on Origin
Discoverer

Comments
	Alleles fall into an allelic series based on leg length defect. In order of decreasing severity of phenotype: AP-2² = AP-2³ = AP-2⁴ = AP-2⁵ = AP-2¹³ = AP-2¹⁴ = AP-2¹⁵ = AP-2¹⁶ = AP-2¹⁹ > AP-2⁸ = AP-2¹² > AP-2¹¹ > AP-2¹⁷ > AP-2¹⁸ > AP-2¹⁰ = AP-2⁹. (Monge et al., 2001)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	AP-2⁴ TfAP-2⁴
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Monge et al., 2001, Development 128(8): 1239--1252 Drosophila transcription factor AP-2 in proboscis, leg and brain central complex development. [FBrf0134567]

Allele Dmel\TfAP-24

Allele Dmel\TfAP-2⁴