Amino acid replacement: G287R. Nucleotide substitution: G?A.
G21612261A
G?A
G287R | TfAP-2-PA; G291R | TfAP-2-PB; G285R | TfAP-2-PC; G297R | TfAP-2-PD; G293R | TfAP-2-PE; G291R | TfAP-2-PF
G287R
adult sense organ | ectopic (with TfAP-28)
adult sense organ | ectopic (with TfAP-217)
antenna | increased number (with TfAP-28)
Pharate pupae and the few eclosing adults show a short leg phenotype. Leg length = 90-95% wild type. All joints are present, but frequently necrotic. Femur-tibia joint necrosis is frequently coincident with detachment of the tibial levator muscle from the joint. Mutants stand with difficulty and occasionally take feeble steps. The proboscis is shorter than wild type but is normal in width. Heterozygotes with AP-28 or AP-217 have normal or nearly normal legs and moderate incidences of necrotic joints and ectopic cuticular elements with sensory structures that invade medioventral eye territory. In rare instances in AP-28/AP-210 flies supernumerary antennae develop and the adjacent eye is reduced.
Alleles fall into an allelic series based on leg length defect. In order of decreasing severity of phenotype: AP-22 = AP-23 = AP-24 = AP-25 = AP-213 = AP-214 = AP-215 = AP-216 = AP-219 > AP-28 = AP-212 > AP-211 > AP-217 > AP-218 > AP-210 = AP-29.