Allele Dmel\TfAP-2¹⁰

General Information
Symbol	Dmel\TfAP-2¹⁰	Species	D. melanogaster
Name		FlyBase ID	FBal0123342
Feature type	allele	Associated gene	Dmel\TfAP-2

Map ( GBrowse )
Allele class	hypomorphic allele - genetic evidence
Mutagen	ethyl methanesulfonate
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	hypomorphic allele - genetic evidence (Monge et al., 2001)
Mutagen	ethyl methanesulfonate (Monge et al., 2001)
Mutations Mapped to the Genome

Type Location Additional Notes References point mutation 3L:21,605,361..21,605,361 evidence=experimental pr_change=G287R\|AP-2-PA,G291R\|AP-2-PB reported_na_change=G?A reported_pr_change=G287R na_change=G21605361A (Monge et al., 2001)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: G287R. Nucleotide substitution: G?A. (Monge et al., 2001)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| adult stage \| recessive (Monge et al., 2001) uncoordinated \| adult stage \| recessive (Monge et al., 2001) viable (with TfAP-2⁸) (Monge et al., 2001) viable (with TfAP-2¹⁷) (Monge et al., 2001)
Phenotype Manifest In
	adult sense organ \| ectopic (with TfAP-2⁸) (Monge et al., 2001) adult sense organ \| ectopic (with TfAP-2¹⁷) (Monge et al., 2001) antenna \| supernumerary (with TfAP-2⁸) (Monge et al., 2001) eye (with TfAP-2⁸) (Monge et al., 2001) eye (with TfAP-2¹⁷) (Monge et al., 2001) joint (Monge et al., 2001) joint (with TfAP-2⁸) (Monge et al., 2001) joint (with TfAP-2¹⁷) (Monge et al., 2001) leg (Monge et al., 2001) proboscis (Monge et al., 2001) tibial levator muscle (Monge et al., 2001) tibial levator muscle (with TfAP-2⁸) (Monge et al., 2001)
Detailed Description
	Statement Reference Pharate pupae and the few eclosing adults show a short leg phenotype. Leg length = 90-95% wild type. All joints are present, but frequently necrotic. Femur-tibia joint necrosis is frequently coincident with detachment of the tibial levator muscle from the joint. Mutants stand with difficulty and occasionally take feeble steps. The proboscis is shorter than wild type but is normal in width. Heterozygotes with AP-2⁸ or AP-2¹⁷ have normal or nearly normal legs and moderate incidences of necrotic joints and ectopic cuticular elements with sensory structures that invade medioventral eye territory. In rare instances in AP-2⁸/AP-2¹⁰ flies supernumerary antennae develop and the adjacent eye is reduced. (Monge et al., 2001)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Partially complements	TfAP-2⁸ (Monge et al., 2001) TfAP-2¹⁷ (Monge et al., 2001)
Comments
Stocks ( 1 )
Bloomington	23720 y¹ w^*; P{Car20y}73C TfAP-2¹⁰ P{neoFRT}80B/TM3, P{sE-raf^torY9}3, Sb¹
Notes on Origin
Discoverer

Comments
	Alleles fall into an allelic series based on leg length defect. In order of decreasing severity of phenotype: AP-2² = AP-2³ = AP-2⁴ = AP-2⁵ = AP-2¹³ = AP-2¹⁴ = AP-2¹⁵ = AP-2¹⁶ = AP-2¹⁹ > AP-2⁸ = AP-2¹² > AP-2¹¹ > AP-2¹⁷ > AP-2¹⁸ > AP-2¹⁰ = AP-2⁹. (Monge et al., 2001)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	AP-2¹⁰ TfAP-2¹⁰
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Monge et al., 2001, Development 128(8): 1239--1252 Drosophila transcription factor AP-2 in proboscis, leg and brain central complex development. [FBrf0134567]

Allele Dmel\TfAP-210

Allele Dmel\TfAP-2¹⁰