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General Information
Symbol
Dmel\TfAP-210
Species
D. melanogaster
Name
FlyBase ID
FBal0123342
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

G21612261A

Reported nucleotide change:

G?A

Amino acid change:

G287R | TfAP-2-PA; G291R | TfAP-2-PB; G285R | TfAP-2-PC; G297R | TfAP-2-PD; G293R | TfAP-2-PE; G291R | TfAP-2-PF

Reported amino acid change:

G287R

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: G287R. Nucleotide substitution: G?A.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Pharate pupae and the few eclosing adults show a short leg phenotype. Leg length = 90-95% wild type. All joints are present, but frequently necrotic. Femur-tibia joint necrosis is frequently coincident with detachment of the tibial levator muscle from the joint. Mutants stand with difficulty and occasionally take feeble steps. The proboscis is shorter than wild type but is normal in width. Heterozygotes with AP-28 or AP-217 have normal or nearly normal legs and moderate incidences of necrotic joints and ectopic cuticular elements with sensory structures that invade medioventral eye territory. In rare instances in AP-28/AP-210 flies supernumerary antennae develop and the adjacent eye is reduced.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
Comments
Comments

Alleles fall into an allelic series based on leg length defect. In order of decreasing severity of phenotype: AP-22 = AP-23 = AP-24 = AP-25 = AP-213 = AP-214 = AP-215 = AP-216 = AP-219 > AP-28 = AP-212 > AP-211 > AP-217 > AP-218 > AP-210 = AP-29.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
AP-210
TfAP-210
Name Synonyms
Secondary FlyBase IDs
    References (1)