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General Information
Symbol
Dmel\RanG19V.Q69L.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0123740
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference
UASt regulatory sequences drive expression of a mutated form of Ran (carries the amino acid replacements G19V and Q69L).
Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Flies expressing ranG19V.Q69L.Scer\UAS under the control of Scer\GAL4nub.PK or Scer\GAL4elav.PLu die during the late first instar stage. First instar larvae show no abnormal behavioural phenotypes. No defects in axonal outgrowth or axon fascicle development are seen during embryogenesis. Flies expressing ranG19V.Q69L.Scer\UAS under the control of Scer\GAL4h-1J3 die during the late second instar stage. First instar larvae show no abnormal behavioural phenotypes. No defects in axonal outgrowth or axon fascicle development are seen during embryogenesis. Flies expressing ranG19V.Q69L.Scer\UAS under the control of Scer\GAL4pros.PMG die as pharate adults with no morphological defects. First instar larvae show no abnormal behavioural phenotypes. No defects in axonal outgrowth or axon fascicle development are seen during embryogenesis. Flies expressing ranG19V.Q69L.Scer\UAS under the control of Scer\GAL4sev.EP.M show partial loss of photoreceptor cells (including loss of R7), resulting in a rough eye phenotype. Flies expressing ranG19V.Q69L.Scer\UAS under the control of Scer\GAL4GMR.PF show complete loss of photoreceptor, pigment and cone cells. The development of the interommatidial bristles appears unaffected.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Phenotype Manifest In
Suppressed by
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
RanG19V.Q69L.Scer\UAS
RanG19V.Q69L.UAS
ranG19V.Q69L.Scer\UAS
Name Synonyms
Secondary FlyBase IDs
    References (2)