FlyBase Allele Report: Dmel\RpL15[8-1]

General Information

Symbol

Dmel\RpL15^8-1

Species

D. melanogaster

Name

FlyBase ID

FBal0123788

Feature type

allele

Associated gene

Dmel\RpL15

Associated Insertion(s)

P{}RpL15^8-1

Carried in Construct

Also Known As

l(3)80Fi^8-1

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Schulze et al., 2005)

Mutagen

Delta2-3 transposase

(Schulze et al., 2001)

P-element activity

(Sinclair et al., 2000)

Progenitor genotype

Associated Insertion(s)

P{}RpL15^8-1

Cytology

Description

Insertion of a 1980bp P-element in the RpL15 promoter region. The P-element is inserted in the opposite orientation to the direction of transcription of RpL15.

(Schulze et al., 2005)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Schulze et al., 2001)

partially lethal (with RpL15^PΔ2)

(Schulze et al., 2005)

partially lethal (with RpL15^PΔ8)

(Schulze et al., 2005)

sterile (with RpL15^PΔ2)

(Schulze et al., 2001)

sterile (with RpL15^PΔ8)

(Schulze et al., 2001)

visible (with RpL15^PΔ2)

(Schulze et al., 2001)

visible (with RpL15^PΔ8)

(Schulze et al., 2001)

Phenotype Manifest In

eye (with RpL15^PΔ2)

(Schulze et al., 2001)

eye (with RpL15^PΔ8)

(Schulze et al., 2001)

gonad (with RpL15^PΔ2)

(Schulze et al., 2001)

gonad (with RpL15^PΔ8)

(Schulze et al., 2001)

macrochaeta (with RpL15^PΔ2)

(Schulze et al., 2001)

macrochaeta (with RpL15^PΔ8)

(Schulze et al., 2001)

male genitalia (with RpL15^PΔ2)

(Schulze et al., 2001)

male genitalia (with RpL15^PΔ8)

(Schulze et al., 2001)

wing (with RpL15^PΔ2)

(Schulze et al., 2001)

wing (with RpL15^PΔ8)

(Schulze et al., 2001)

wing hair (with RpL15^PΔ2)

(Schulze et al., 2001)

wing hair (with RpL15^PΔ8)

(Schulze et al., 2001)

wing vein (with RpL15^PΔ2)

(Schulze et al., 2001)

wing vein (with RpL15^PΔ8)

(Schulze et al., 2001)

Detailed Description

Statement

Reference

Adult survivors transheterozygotes with RpL15^PΔ2 or RpL15^PΔ8 are sterile with underdeveloped gonads and show reduced body size, small and thin bristles, rough and/or reduced eyes, misrotated genitalia (males) and wing, wing vein and wing hair phenotypes. Reducing the growth temperature to 22^oC (as compared to 25^oC) increases the incidence of survivors. Sex ratios are also skewed in favour of males in the survivors. An exception is the RpL15^8-1/RpL15^PΔ2 combination where sex ratios is normal.

(Schulze et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially complements

RpL15^PΔ8

(Schulze et al., 2001)

Fails to complement

RpL15^7-1

(Schulze et al., 2001)

RpL15⁷²

(Schulze et al., 2001)

RpL15^PΔ2

(Schulze et al., 2001)

RpL15³

(Schulze et al., 2001)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

81861

RpL15^8-1/TM3, Sb¹ Ser¹

Notes on Origin

Discoverer

RpL15^7-1 and RpL15^8-1 may be duplicate isolations of the same mutation, as they were isolated in the same screen, and the insertion is in the same location and orientation in each case.

(Schulze et al., 2005)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

8-1

(Schulze et al., 2005)

RpL15^8-1

l(3)80Fi^8-1

(Schulze et al., 2001, Sinclair et al., 2000)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

Open Close