Allele Dmel\dsh^{T:Avic\GFP-EGFP}

General Information
Symbol	Dmel\dsh^{T:Avic\GFP-EGFP}	Species	D. melanogaster
Name		FlyBase ID	FBal0123908
Feature type	allele	Associated gene	Dmel\dsh

Allele class
Mutagen	in vitro construct - coding region fusion
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - coding region fusion (Axelrod, 2001)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Construct: 6.7kb genomic fragment containing dsh tagged at the 3' end with "enhanced" GFP (T:Avic\GFP^EGFP). (Axelrod, 2001)
Carried in construct	P{dsh.EGFP} (Simons et al., 2009, Kaltschmidt et al., 2002, Amonlirdviman et al., 2005, Yang et al., 2002, Cohen et al., 2002, Ma et al., 2003, Wu et al., 2004, Venema et al., 2004, Axelrod, 2001, Djiane et al., 2005, Wu et al., 2008, Yanfeng et al., 2011)
Tagged with	T:Avic\GFP^EGFP (Axelrod, 2001, Yang et al., 2002, Cohen et al., 2002, Ma et al., 2003, Kaltschmidt et al., 2002, Wu et al., 2004, Venema et al., 2004, Amonlirdviman et al., 2005)
Cytology
Phenotypic Data
Phenotypic Class
	wild-type (Axelrod, 2001)
Phenotype Manifest In

Detailed Description
	Statement Reference Flies expressing dsh[T:Avic\GFP-EGFP] in a dsh[3] background exhibit wild type PCP patterns in all tissues examined. (Yanfeng et al., 2011)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressor of
Statement Reference dsh^{T:Avic\GFP-EGFP} is a suppressor \| partially of wing margin phenotype of Scer\GAL4^en-e16E, fz^{1-1-1.Scer\UAS.T:Hsap\MYC} (Wu et al., 2004)
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescues	dsh^{T:Avic\GFP-EGFP} rescues dsh³ (Axelrod, 2001, Yanfeng et al., 2011)
Comments	Expression of dsh[T:Avic\GFP-EGFP] fully rescues the lethality and PCP defects seen in dsh[3] mutants. (Yanfeng et al., 2011)
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	dsh^T:Avic\GFP dsh^{T:Avic\GFP-EGFP}
Name Synonym
Secondary FlyBase IDs

References ( 13 )
Research paper	Yanfeng et al., 2011, Dev. Biol. 360(1): 132--142 Functional dissection of phosphorylation of Disheveled in Drosophila. [FBrf0216602] Simons et al., 2009, Nat. Cell Biol. 11(3): 286--294 Electrochemical cues regulate assembly of the Frizzled/Dishevelled complex at the plasma membrane during planar epithelial polarization. [FBrf0207478] Wu et al., 2008, Mech. Dev. 125(1-2): 30--42 Frizzled-Dishevelled signaling specificity outcome can be modulated by Diego in Drosophila. [FBrf0200663] Amonlirdviman et al., 2005, Science 307(5708): 423--426 Mathematical modeling of planar cell polarity to understand domineering nonautonomy. [FBrf0188460] Djiane et al., 2005, Cell 121(4): 621--631 The apical determinants aPKC and dPatj regulate Frizzled-dependent planar cell polarity in the Drosophila eye. [FBrf0187224] Venema et al., 2004, Dev. Biol. 275(2): 301--314 Transient apical polarization of Gliotactin and Coracle is required for parallel alignment of wing hairs in Drosophila. [FBrf0180106] Wu et al., 2004, PLoS Biol. 2(7): e158 Subcellular localization of frizzled receptors, mediated by their cytoplasmic tails, regulates signaling pathway specificity. [FBrf0179518] Ma et al., 2003, Nature 421(6922): 543--547 Fidelity in planar cell polarity signalling. [FBrf0155499] Cohen et al., 2002, Dev. Cell 2(4): 437--448 DWnt4 regulates cell movement and focal adhesion kinase during Drosophila ovarian morphogenesis. [FBrf0146974] He and Adler, 2002, BMC Dev. Biol. 2(1): 7 The frizzled pathway regulates the development of arista laterals. [FBrf0148895] Kaltschmidt et al., 2002, Nat. Cell Biol. 4(12): 937--944 Planar polarity and actin dynamics in the epidermis of Drosophila. [FBrf0155993] Yang et al., 2002, Cell 108(5): 675--688 Regulation of frizzled by fat-like cadherins during planar polarity signaling in the Drosophila compound eye. [FBrf0146910] Axelrod, 2001, Genes Dev. 15(10): 1182--1187 Unipolar membrane association of Dishevelled mediates Frizzled planar cell polarity signaling. [FBrf0135774]

Allele Dmel\dshT:Avic\GFP-EGFP

Allele Dmel\dsh^{T:Avic\GFP-EGFP}