FlyBase Allele Report: Dmel\Tak1[UAS.cMa]

Neuronal overexpression of Tak1^Scer\UAS.cMa under the control of Scer\GAL4^nSyb.PS elicit a significant synaptic overgrowth phenotype, with an expanded synapse consisting of several very small boutons.

(West et al., 2015)

Expression of Tak1^Scer\UAS.cMa under the control of Scer\GAL4^sev.PU triggers extensive cell death in larval eye discs and produces rough eyes with reduced sizes.

(Ma et al., 2014)

Flies expressing Tak1^Scer\UAS.cMa under the control of Scer\GAL4^yolk are noticeably unhealthy and show altered organisation and loss of fat body tissue over the course of a few days.

(Stronach et al., 2014)

Expression of Tak1^Scer\UAS.cMa under the control of Scer\GAL4^hs.2sev produces rough eyes with reduced size.

(Ma et al., 2013)

Expression of Tak1^Scer\UAS.cMa under the control of Scer\GAL4^ptc-559.1 results in degradation of the basement membrane of wing discs.

(Srivastava et al., 2007)

Expression of Tak1^Scer\UAS.cMa under the control of Scer\GAL4^hs.2sev results in rough eyes that are smaller than normal.

(Xue et al., 2007)

When Tak1^Scer\UAS.cMa is driven by Scer\GAL4^hs.2sev at 18^oC, polarity defects are seen in the eye affecting both rotation and chirality, and also some loss of photoreceptors. When Tak1^Scer\UAS.cMa is driven by Scer\GAL4^hs.2sev at 25^oC a very severe eye phenotype is observed. The adult eye is severely reduced in size and the structure of the ommatidial clusters is completely disrupted with photoreceptor cells often lost or not differentiated. Other drivers cause lethality at this temperature.

(Mihaly et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^hs.2sev, Tak1^UAS.cMa has visible phenotype, suppressible | partially by hep[+]/hep¹

(Xue et al., 2007)

Scer\GAL4^hs.2sev, Tak1^UAS.cMa has visible phenotype, suppressible | partially by bsk¹/bsk[+]

(Xue et al., 2007)

Scer\GAL4^hs.2sev, Tak1^UAS.cMa has abnormal planar polarity phenotype, suppressible by Df(2L)b87e25

(Mihaly et al., 2001)

Scer\GAL4^hs.2sev, Tak1^UAS.cMa has abnormal planar polarity phenotype, suppressible by Df(3R)crb87-4

(Mihaly et al., 2001)

Scer\GAL4^hs.2sev, Tak1^UAS.cMa has abnormal planar polarity phenotype, suppressible by Jra³

(Mihaly et al., 2001)

Scer\GAL4^hs.2sev, Tak1^UAS.cMa has abnormal planar polarity phenotype, suppressible by nmo^j147-1

(Mihaly et al., 2001)

Scer\GAL4^hs.2sev, Tak1^UAS.cMa has abnormal planar polarity phenotype, suppressible | partially by hep^r75

(Mihaly et al., 2001)

Scer\GAL4^hs.2sev, Tak1^UAS.cMa has abnormal planar polarity phenotype, suppressible | partially by msn¹⁷²

(Mihaly et al., 2001)

Scer\GAL4^hs.2sev, Tak1^UAS.cMa has abnormal planar polarity phenotype, suppressible by Df(2L)flp170B

(Mihaly et al., 2001)

Scer\GAL4^hs.2sev, Tak1^UAS.cMa has abnormal planar polarity phenotype, suppressible by Scer\GAL4^hs.2sev/bsk^K53R.UAS

(Mihaly et al., 2001)

Scer\GAL4^hs.2sev, Tak1^UAS.cMa has increased cell death phenotype, suppressible | partially by BacA\p35^UAS.cHa, Scer\GAL4^hs.2sev

(Mihaly et al., 2001)

NOT suppressed by

Statement

Reference

Scer\GAL4^sev.PU, Tak1^UAS.cMa has visible phenotype, non-suppressible by ben¹

(Ma et al., 2014)

Scer\GAL4^hs.2sev, Tak1^UAS.cMa has visible phenotype, non-suppressible by Uev1A^GD6650/Scer\GAL4^hs.2sev

(Ma et al., 2013)

Scer\GAL4^hs.2sev, Tak1^UAS.cMa has visible phenotype, non-suppressible by CYLD^mr4/CYLD^mr4

(Xue et al., 2007)

Scer\GAL4^hs.2sev, Tak1^UAS.cMa has visible phenotype, non-suppressible by Scer\GAL4^hs.2sev/Traf6^RNAi.UAS

(Xue et al., 2007)

Scer\GAL4^hs.2sev, Tak1^UAS.cMa has visible phenotype, non-suppressible by Traf6^ex1/Traf6^ex1

(Xue et al., 2007)

Scer\GAL4^hs.2sev, Tak1^UAS.cMa has abnormal planar polarity phenotype, non-suppressible by Mad¹²

(Mihaly et al., 2001)

Scer\GAL4^hs.2sev, Tak1^UAS.cMa has abnormal planar polarity phenotype, non-suppressible by dpp^d12

(Mihaly et al., 2001)

Scer\GAL4^hs.2sev, Tak1^UAS.cMa has abnormal planar polarity phenotype, non-suppressible by tkv⁴

(Mihaly et al., 2001)

Suppressor of

Statement

Reference

Tak1^UAS.cMa, Scer\GAL4^pnr-MD237 is a suppressor of visible phenotype of CYLD^UAS.cXa, Scer\GAL4^pnr-MD237

(Xue et al., 2007)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^ptc-559.1, Tak1^UAS.cMa has basement membrane phenotype, suppressible by Scer\GAL4^ptc-559.1/Timp^UAS.cSa

(Srivastava et al., 2007)

Scer\GAL4^hs.2sev, Tak1^UAS.cMa has eye phenotype, suppressible | partially by hep[+]/hep¹

(Xue et al., 2007)

Scer\GAL4^hs.2sev, Tak1^UAS.cMa has eye phenotype, suppressible | partially by bsk¹/bsk[+]

(Xue et al., 2007)

Scer\GAL4^hs.2sev, Tak1^UAS.cMa has eye phenotype, suppressible by Df(2L)b87e25

(Mihaly et al., 2001)

Scer\GAL4^hs.2sev, Tak1^UAS.cMa has eye phenotype, suppressible by Df(3R)crb87-4

(Mihaly et al., 2001)

Scer\GAL4^hs.2sev, Tak1^UAS.cMa has eye phenotype, suppressible by Jra³

(Mihaly et al., 2001)

Scer\GAL4^hs.2sev, Tak1^UAS.cMa has eye phenotype, suppressible by Df(2L)flp170B

(Mihaly et al., 2001)

Scer\GAL4^hs.2sev, Tak1^UAS.cMa has eye phenotype, suppressible by nmo^j147-1

(Mihaly et al., 2001)

Scer\GAL4^hs.2sev, Tak1^UAS.cMa has eye phenotype, suppressible | partially by hep^r75

(Mihaly et al., 2001)

Scer\GAL4^hs.2sev, Tak1^UAS.cMa has eye phenotype, suppressible | partially by msn¹⁷²

(Mihaly et al., 2001)

Scer\GAL4^hs.2sev, Tak1^UAS.cMa has eye photoreceptor cell phenotype, suppressible by Df(2L)b87e25

(Mihaly et al., 2001)

Scer\GAL4^hs.2sev, Tak1^UAS.cMa has eye photoreceptor cell phenotype, suppressible by Df(3R)crb87-4

(Mihaly et al., 2001)

Scer\GAL4^hs.2sev, Tak1^UAS.cMa has eye photoreceptor cell phenotype, suppressible by Jra³

(Mihaly et al., 2001)

Scer\GAL4^hs.2sev, Tak1^UAS.cMa has eye photoreceptor cell phenotype, suppressible by Df(2L)flp170B

(Mihaly et al., 2001)

Scer\GAL4^hs.2sev, Tak1^UAS.cMa has eye photoreceptor cell phenotype, suppressible by nmo^j147-1

(Mihaly et al., 2001)

Scer\GAL4^hs.2sev, Tak1^UAS.cMa has eye photoreceptor cell phenotype, suppressible | partially by hep^r75

(Mihaly et al., 2001)

Scer\GAL4^hs.2sev, Tak1^UAS.cMa has eye photoreceptor cell phenotype, suppressible | partially by msn¹⁷²

(Mihaly et al., 2001)

Scer\GAL4^hs.2sev, Tak1^UAS.cMa has eye phenotype, suppressible by Scer\GAL4^hs.2sev/bsk^K53R.UAS

(Mihaly et al., 2001)

Scer\GAL4^hs.2sev, Tak1^UAS.cMa has eye photoreceptor cell phenotype, suppressible by Scer\GAL4^hs.2sev/bsk^K53R.UAS

(Mihaly et al., 2001)

NOT suppressed by

Statement

Reference

Scer\GAL4^sev.PU, Tak1^UAS.cMa has eye phenotype, non-suppressible by ben¹

(Ma et al., 2014)

Scer\GAL4^hs.2sev, Tak1^UAS.cMa has eye phenotype, non-suppressible by Uev1A^GD6650/Scer\GAL4^hs.2sev

(Ma et al., 2013)

Scer\GAL4^ptc-559.1, Tak1^UAS.cMa has basement membrane phenotype, non-suppressible by BacA\p35^UAS.cHa, Scer\GAL4^ptc-559.1

(Srivastava et al., 2007)

Scer\GAL4^hs.2sev, Tak1^UAS.cMa has eye phenotype, non-suppressible by CYLD^mr4/CYLD^mr4

(Xue et al., 2007)

Scer\GAL4^hs.2sev, Tak1^UAS.cMa has eye phenotype, non-suppressible by Scer\GAL4^hs.2sev/Traf6^RNAi.UAS

(Xue et al., 2007)

Scer\GAL4^hs.2sev, Tak1^UAS.cMa has eye phenotype, non-suppressible by Traf6^ex1/Traf6^ex1

(Xue et al., 2007)

Scer\GAL4^hs.2sev, Tak1^UAS.cMa has eye phenotype, non-suppressible by Mad¹²

(Mihaly et al., 2001)

Scer\GAL4^hs.2sev, Tak1^UAS.cMa has eye phenotype, non-suppressible by dpp^d12

(Mihaly et al., 2001)

Scer\GAL4^hs.2sev, Tak1^UAS.cMa has eye phenotype, non-suppressible by tkv⁴

(Mihaly et al., 2001)

Scer\GAL4^hs.2sev, Tak1^UAS.cMa has eye photoreceptor cell phenotype, non-suppressible by Mad¹²

(Mihaly et al., 2001)

Scer\GAL4^hs.2sev, Tak1^UAS.cMa has eye photoreceptor cell phenotype, non-suppressible by dpp^d12

(Mihaly et al., 2001)

Scer\GAL4^hs.2sev, Tak1^UAS.cMa has eye photoreceptor cell phenotype, non-suppressible by tkv⁴

(Mihaly et al., 2001)

Suppressor of

Statement

Reference

Tak1^UAS.cMa, Scer\GAL4^pnr-MD237 is a suppressor of scutellum phenotype of CYLD^UAS.cXa, Scer\GAL4^pnr-MD237

(Xue et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

ben¹ has no effect on the rough eye phenotype seen when Tak1^Scer\UAS.cMa is expressed under the control of Scer\GAL4^sev.PU.

(Ma et al., 2014)

Loss of Uev1A, through co-expression of Uev1A^GD6650, fails to suppress the rough eye phenotype seen when Tak1^Scer\UAS.cMa is expressed under the control of Scer\GAL4^hs.2sev.

(Ma et al., 2013)

The degradation of the wing disc basement membrane that is seen in animals expressing Tak1^Scer\UAS.cMa under the control of Scer\GAL4^ptc-559.1 is suppressed by co-expression of Timp^Scer\UAS.cSa.

(Srivastava et al., 2007)

Homozygosity for CYLD^mr4 (animals homozygous for Df(2L)CYLD^mr4 and carrying P{LX107} to rescue the function of CG13138 and nmd) has no effect on the mutant eye phenotype caused by expression of Tak1^Scer\UAS.cMa under the control of Scer\GAL4^hs.2sev.

Homozygosity for Traf6^ex1 or co-expression of Traf6^{dsRNA.Scer\UAS} has no effect on the mutant eye phenotype caused by expression of Tak1^Scer\UAS.cMa under the control of Scer\GAL4^hs.2sev.

Heterozygosity for either hep¹ or bsk¹ partially suppresses the mutant eye phenotype caused by expression of Tak1^Scer\UAS.cMa under the control of Scer\GAL4^hs.2sev.

Co-expression of Tak1^Scer\UAS.cMa fully suppresses the reduced scutellum phenotype caused by expression of CYLD^Scer\UAS.cXa under the control of Scer\GAL4^pnr-MD237.

(Xue et al., 2007)

Xenogenetic Interactions

Statement

Reference

The degradation of the wing disc basement membrane that is seen in animals expressing Tak1^Scer\UAS.cMa under the control of Scer\GAL4^ptc-559.1 still occurs if BacA\p35^Scer\UAS.cHa is co-expressed.

(Srivastava et al., 2007)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

58810

w^*; P{UAS-Tak1.M}T8

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Tak1^Scer\UAS.cMa

Tak1^UAS.cMa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Mihaly

(Mihaly et al., 2001)

Secondary FlyBase IDs

References (10)

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