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General Information
Symbol
Dmel\Hsc70-4Δ11
Species
D. melanogaster
Name
FlyBase ID
FBal0124179
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
deletion
Comment:

Imprecise excision of the EP(3)0859 P-element, deleting 1666 nucleotides, including the promoter and first exon of Hsc70-4. Position of mutation on reference sequence inferred by FlyBase curator.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Df(3R)Hsc70-4Δ11 has a breakpoint within the first intron of the Hsc70-4 gene. Deletion spans -813 to +853.

Caused by aberration
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous larvae show sporadic but reduced muscle contractions. The quantal content of evoked release in homozygotes and Hsc70-4Δ19/Hsc70-4Δ11 transheterozygotes is reduced to a third to a half of control. The EJP amplitudes recorded from mutant neuromuscular junctions (NMJs) are reduced to about 3/4 of control amplitudes.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhanced by
Statement
Reference

Hsc70-4Δ11 has axon | larval stage phenotype, enhanceable by CspX1

Enhancer of
Statement
Reference

Hsc70-4Δ11 is an enhancer of axon | larval stage phenotype of CspX1

Additional Comments
Genetic Interactions
Statement
Reference

The EJP amplitudes recorded from Hsc70-4Δ11, CspX1 double mutant neuromuscular junctions (NMJs) are reduced to about 1/2 of control amplitudes.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Hsc70-4Δ11
Name Synonyms
Secondary FlyBase IDs
    References (2)