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General Information
Symbol
Dmel\ptc1130X.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0124967
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
1130X, UAS-Ptc1130x, UAS-PtcDN
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt sequences drove expression of a mutated ptc - a stop codon and an XbalI site have been introduced after codon 1130.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Compared to controls unresponsive to a 38[o]C probe (without pre-exposure to UV), early third instar larvae with expression of ptc1130X.Scer\UAS driven by Scer\GAL4ppk.1.9 show significant withdrawal responses (genetic allodynia).

When ptc1130X.Scer\UAS is driven by Scer\GAL471B, ectopic venation and expansion of the anterior region of the wing is seen. The intervein region between wing veins 3 and 4 is reduced.

When ptc1130X.Scer\UAS is driven by Scer\GAL471B the size of the anterior compartment of the wing is increased the posterior region is unaffected. The number of campaniform sensilla is increased, as is the length of the double row bristle region. There is slight disorganisation of the vein 3 region and proximal fusion of veins 3 and 4. The addition of heterozygous ptc10 enhances the wing phenotypes seen in ptc1130X.Scer\UAS, Scer\GAL471B flies alone. There is increased venation in the vein 3 region and a larger row of bristles at the wing margin. When ptc1130X.Scer\UAS is driven by Scer\GAL4en-e16E, much of the wing pattern between veins 1 and 5 is deleted.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
NOT suppressed by
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Co-expression of TkR99DGD375 does not suppress withdrawal responses to a 38[o]C probe (without pre-exposure to UV) seen in early third instar larvae with expression of ptc1130X.Scer\UAS driven by Scer\GAL4ppk.1.9.

Co-expression of enKK107874 suppresses the withdrawal responses to a 38[o]C probe (without pre-exposure to UV) seen in early third instar larvae with expression of ptc1130X.Scer\UAS driven by Scer\GAL4ppk.1.9.

Co-expression of dispGD2813 does not significantly suppress the withdrawal responses to a 38[o]C probe (without pre-exposure to UV) seen in early third instar larvae with ptc1130X.Scer\UAS driven by Scer\GAL4ppk.1.9.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to rescue
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
ptc1130X.Scer\UAS
ptc1130X.UAS
Name Synonyms
Secondary FlyBase IDs
    References (9)