Allele Dmel\phl^Act.Scer\UAS

General Information
Symbol	Dmel\phl^Act.Scer\UAS	Species	D. melanogaster
Name		FlyBase ID	FBal0124968
Feature type	allele	Associated gene	Dmel\phl

Allele class
Mutagen	in vitro construct - regulatory fusion
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Kumar and Moses, 2001)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Carried in construct	P{UAS-phl.Act} (Kumar and Moses, 2001, Kumar and Moses, 2001, Guichard et al., 2006, Galindo et al., 2011)
Cytology
Phenotypic Data
Phenotypic Class
	visible \| homeotic, with Scer\GAL4^ey.PB (Kumar and Moses, 2001)
Phenotype Manifest In
	antenna \| ectopic, with Scer\GAL4^ey.PB (Kumar and Moses, 2001) eye, with Scer\GAL4^ey.PB (Kumar and Moses, 2001) morphogenetic furrow \| ectopic, with Scer\GAL4^dpp.blk1 (Kumar and Moses, 2001) wing vein \| ectopic, with Scer\GAL4^CY2 (Guichard et al., 2006)
Detailed Description
	Statement Reference Expression of phl[Act.Scer\UAS] under the control of Scer\GAL4[CY2] results in a strong ectopic wing vein phenotype. (Guichard et al., 2006) Expression of phl^Act.Scer\UAS under the control of Scer\GAL4^ey.PB can result in homeotic transformation of the eye to antenna. The ectopic antenna has all segments including the arista and is oriented similarly to the endogenous antenna. (Kumar and Moses, 2001) Expression of phl^Act.Scer\UAS under the control of Scer\GAL4^dpp.blk1 results in ectopic furrow formation in the eye disc. (Kumar and Moses, 2001)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressed by
Statement Reference phl^Act.Scer\UAS has wing vein \| ectopic phenotype, suppressible by Scer\GAL4^CY2/Zzzz\lef^Scer\UAS.cGa (Guichard et al., 2006)
NOT suppressed by
Statement Reference Scer\GAL4^dpp.blk1, phl^Act.Scer\UAS has morphogenetic furrow \| ectopic phenotype, non-suppressible by wg^Scer\UAS.cLa/Scer\GAL4^dpp.blk1 (Kumar and Moses, 2001)
Additional Comments
Genetic Interactions
Statement Reference Furrow initiation is blocked in eye discs coexpressing phl^Act.Scer\UAS and N^DN.Scer\UAS under the control of Scer\GAL4^dpp.blk1. (Kumar and Moses, 2001)
Xenogenetic Interactions
Statement Reference Expression of Zzzz\lef[Scer\UAS.cGa] suppresses the strong ectopic vein phenotype of phl[Act.Scer\UAS] under the control of Scer\GAL4[CY2]. (Guichard et al., 2006)
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	phl^Act.Scer\UAS
Name Synonym
Secondary FlyBase IDs

References ( 4 )
Research paper	Galindo et al., 2011, Dev. Biol. 353(2): 396--410 Control of Distal-less expression in the Drosophila appendages by functional 3' enhancers. [FBrf0213529] Guichard et al., 2006, Proc. Natl. Acad. Sci. U.S.A. 103(9): 3244--3249 Anthrax lethal factor and edema factor act on conserved targets in Drosophila. [FBrf0191441] Kumar and Moses, 2001, Cell 104(5): 687--697 EGF receptor and Notch signaling act upstream of Eyeless/Pax6 to control eye specification. [FBrf0134490] Kumar and Moses, 2001, Development 128(14): 2689--2697 The EGF receptor and notch signaling pathways control the initiation of the morphogenetic furrow during Drosophila eye development. [FBrf0138358]

Allele Dmel\phlAct.Scer\UAS

Allele Dmel\phl^Act.Scer\UAS