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General Information
Symbol
Dmel\hiwunspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0125005
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    hiwunspecified loss of function alleles show a large increase in the number of synaptic branches, and synaptic span, a small decrease in quantal size and a large decrease in quantal content.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Phenotype Manifest In
    Enhanced by
    Suppressed by
    Statement
    Reference
    NOT suppressed by
    Statement
    Reference

    hiwunspecified has synapse phenotype, non-suppressible by fafFO8/fafBX4

    hiwunspecified has synapse phenotype, non-suppressible by fafBX4

    Additional Comments
    Genetic Interactions
    Statement
    Reference

    The addition of either homozygous fafBX4, or fafBX4/fafFO8 suppresses the physiological phenotype of hiwunspecified, leading to a more tha doubling of both quantal content and mEJP frequency. However the synaptic overgrowth phenotype is not affected. The addition off GluRIIAM614R.Scer\UAS.T:Hsap\MYC to hiw mutants leads to a an 18% decrease in quantal size, no change in the size of the evoked response, and a compensatory 30% increase in quantal content.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (1)
    Reported As
    Symbol Synonym
    hiwunspecified
    Name Synonyms
    Secondary FlyBase IDs
      References (1)