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General Information
Symbol
Dmel\Su(var)2-1214
Species
D. melanogaster
Name
FlyBase ID
FBal0125269
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
Su(var)214
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

One copy of Su(var)2-1214 strongly suppresses position effect variegation (PEV) at the w locus caused by In(1)wm4.

One copy of Su(var)2-1214 is unable to suppress the telomeric position effect (TPE) in stocks carrying a variegating P{hsp26-pt-T}39C-5 insertion at the telomere of the left arm of chromosome two.

Homozygous embryos are semi-viable. Moderate to strong maternal effects as seen by elevated w+ eye pigment levels in non-suppressor bearing offspring of Su(var) females. Removal of segments of heterochromatin from the genome by loss of the Y chromosome abolishes the suppression of the position effect variegation phenotype. The effect of the Su(var)2-1214 allele is reduced in heterozygotes with Df(2R)M41A10 (which lacks 2R heterochromatin).

Does not enhance variegation at the lt locus.

Dominant suppressor of position effect variegation in eye pigment caused by In(1)wm4 or In(2R)bwVDe2. Dominant suppressor of position effect variegation at the Sb locus caused by T(2;3)SbV. The suppressor effect on the variegation caused by In(1)wm4 is substantially reduced or eliminated entirely in male XO flies lacking a Y chromosome.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Su(var)205unspecified shows semi-lethality with Su(var)2-1214 in females with a Y chromosome.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Originally isolated as a dominant suppressor of the w+ gene on In(1)wm4.

Relationship to Su(var)214 of Sinclair (Sinclair, Mol. Gen. Genet. 191: 326--333) is not discussed.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
Reported As
Symbol Synonym
Su(var)2-1210-2
Su(var)2-1214
Suvar(2)1214
Name Synonyms
Secondary FlyBase IDs
  • FBal0016499
References (6)