FlyBase Allele Report: Dmel\Hipk[BG00855]

General Information

Symbol

Dmel\Hipk^BG00855

Species

D. melanogaster

Name

FlyBase ID

FBal0125498

Feature type

allele

Associated gene

Dmel\Hipk

Associated Insertion(s)

P{GT1}Hipk^BG00855

Carried in Construct

Also Known As

BG00855

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Gene Disruption Project members, 2001-)

Progenitor genotype

Associated Insertion(s)

P{GT1}Hipk^BG00855

Cytology

Description

Insertion within the first intron.

(Lee et al., 2009)

Allele components

Component

Use(s)

Inserted element

P{GT1}

gene trap

polyA trap

Encoded product / tool

GAL4

binary expression system - driver

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3L:546,799..546,799 [-]

(Kinsey et al., 2021, Chen et al., 2014, Lee et al., 2009, Gene Disruption Project members, 2001-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

eye | pharate adult stage (with Hipk⁴)

(Kinsey et al., 2021)

ocellar bristle | decreased number | pharate adult stage (with Hipk⁴)

(Kinsey et al., 2021)

ocellus | absent | pharate adult stage (with Hipk⁴)

(Kinsey et al., 2021)

vertical bristle 2 | decreased number | pharate adult stage (with Hipk⁴)

(Kinsey et al., 2021)

Detailed Description

Statement

Reference

Hipk⁴/Hipk^BG00855 pharates dissected from pupal cases show reduced eye size, loss of ocelli, and missing ocellar and posterior vertical bristles.

(Kinsey et al., 2021)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Hipk^BG00855/Hipk⁴ has increased mortality during development phenotype, suppressible | partially by Scer\GAL4^Hipk-BG00855/Hsap\HIPK1^UAS.Tag:MYC

(Kinsey et al., 2021)

Hipk^BG00855/Hipk⁴ has increased mortality during development phenotype, suppressible | partially by Scer\GAL4^Hipk-BG00855/Hsap\HIPK2^UAS.Tag:MYC

(Kinsey et al., 2021)

Hipk^BG00855/Hipk⁴ has decreased size | pharate adult stage phenotype, suppressible | partially by Scer\GAL4^Hipk-BG00855/Hsap\HIPK2^UAS.Tag:MYC

(Kinsey et al., 2021)

NOT suppressed by

Statement

Reference

Hipk^BG00855/Hipk⁴ has lethal - all die before end of P-stage phenotype, non-suppressible by Scer\GAL4^Hipk-BG00855/Hsap\HIPK4^UAS.Tag:MYC

(Kinsey et al., 2021)

Hipk^BG00855/Hipk⁴ has decreased size | pharate adult stage phenotype, non-suppressible by Scer\GAL4^Hipk-BG00855/Hsap\HIPK1^UAS.Tag:MYC

(Kinsey et al., 2021)

Hipk^BG00855/Hipk⁴ has decreased size | pharate adult stage phenotype, non-suppressible by Scer\GAL4^Hipk-BG00855/Hsap\HIPK4^UAS.Tag:MYC

(Kinsey et al., 2021)

Hipk^BG00855/Hipk⁴ has decreased size | pharate adult stage phenotype, non-suppressible by Scer\GAL4^Hipk-BG00855/Hsap\HIPK3^UAS.Tag:MYC

(Kinsey et al., 2021)

Hipk^BG00855/Hipk⁴ has lethal - all die before end of P-stage phenotype, non-suppressible by Scer\GAL4^Hipk-BG00855/Hsap\HIPK3^UAS.Tag:MYC

(Kinsey et al., 2021)

Suppressor of

Statement

Reference

Hipk^BG00855/hipk[+] is a suppressor of visible phenotype of Dys^RNAi.NH2.UAS, Scer\GAL4^Act.PU

(Kucherenko et al., 2008)

Hipk^BG00855/hipk[+] is a suppressor of visible phenotype of Dys^RNAi.C.UAS, Scer\GAL4^Tub.PU

(Kucherenko et al., 2008)

Other

Statement

Reference

Hipk^BG00855/Hipk⁴, Hsap\HIPK1^UAS.Tag:MYC, Scer\GAL4^Hipk-BG00855 has partially lethal - majority die phenotype

(Kinsey et al., 2021)

Hipk^BG00855/Hipk⁴, Hsap\HIPK2^UAS.Tag:MYC, Scer\GAL4^Hipk-BG00855 has partially lethal - majority live phenotype

(Kinsey et al., 2021)

Dys^E6, Hipk^BG00855/hipk[+] has visible phenotype

(Kucherenko et al., 2008)

Phenotype Manifest In

Suppressed by

Statement

Reference

Hipk^BG00855/Hipk⁴ has eye | pharate adult stage phenotype, suppressible | partially by Scer\GAL4^Hipk-BG00855/Hsap\HIPK2^UAS.Tag:MYC

(Kinsey et al., 2021)

Hipk^BG00855/Hipk⁴ has ocellar bristle | pharate adult stage | decreased number phenotype, suppressible | partially by Scer\GAL4^Hipk-BG00855/Hsap\HIPK2^UAS.Tag:MYC

(Kinsey et al., 2021)

Hipk^BG00855/Hipk⁴ has vertical bristle 2 | pharate adult stage | decreased number phenotype, suppressible | partially by Scer\GAL4^Hipk-BG00855/Hsap\HIPK2^UAS.Tag:MYC

(Kinsey et al., 2021)

Hipk^BG00855/Hipk⁴ has ocellus | pharate adult stage | absent phenotype, suppressible by Scer\GAL4^Hipk-BG00855/Hsap\HIPK2^UAS.Tag:MYC

(Kinsey et al., 2021)

Hipk^BG00855/Hipk⁴ has ocellus | pharate adult stage | absent phenotype, suppressible by Scer\GAL4^Hipk-BG00855/Hsap\HIPK3^UAS.Tag:MYC

(Kinsey et al., 2021)

Hipk^BG00855/Hipk⁴ has vertical bristle 2 | pharate adult stage | decreased number phenotype, suppressible by Scer\GAL4^Hipk-BG00855/Hsap\HIPK4^UAS.Tag:MYC

(Kinsey et al., 2021)

Hipk^BG00855/Hipk⁴ has ocellar bristle | pharate adult stage | decreased number phenotype, suppressible by Scer\GAL4^Hipk-BG00855/Hsap\HIPK4^UAS.Tag:MYC

(Kinsey et al., 2021)

NOT suppressed by

Statement

Reference

Hipk^BG00855/Hipk⁴ has eye | pharate adult stage phenotype, non-suppressible by Scer\GAL4^Hipk-BG00855/Hsap\HIPK1^UAS.Tag:MYC

(Kinsey et al., 2021)

Hipk^BG00855/Hipk⁴ has ocellus | pharate adult stage | absent phenotype, non-suppressible by Scer\GAL4^Hipk-BG00855/Hsap\HIPK1^UAS.Tag:MYC

(Kinsey et al., 2021)

Hipk^BG00855/Hipk⁴ has ocellar bristle | pharate adult stage | decreased number phenotype, non-suppressible by Scer\GAL4^Hipk-BG00855/Hsap\HIPK1^UAS.Tag:MYC

(Kinsey et al., 2021)

Hipk^BG00855/Hipk⁴ has vertical bristle 2 | pharate adult stage | decreased number phenotype, non-suppressible by Scer\GAL4^Hipk-BG00855/Hsap\HIPK1^UAS.Tag:MYC

(Kinsey et al., 2021)

Hipk^BG00855/Hipk⁴ has eye | pharate adult stage phenotype, non-suppressible by Scer\GAL4^Hipk-BG00855/Hsap\HIPK3^UAS.Tag:MYC

(Kinsey et al., 2021)

Hipk^BG00855/Hipk⁴ has ocellar bristle | pharate adult stage | decreased number phenotype, non-suppressible by Scer\GAL4^Hipk-BG00855/Hsap\HIPK3^UAS.Tag:MYC

(Kinsey et al., 2021)

Hipk^BG00855/Hipk⁴ has vertical bristle 2 | pharate adult stage | decreased number phenotype, non-suppressible by Scer\GAL4^Hipk-BG00855/Hsap\HIPK3^UAS.Tag:MYC

(Kinsey et al., 2021)

Hipk^BG00855/Hipk⁴ has eye | pharate adult stage phenotype, non-suppressible by Scer\GAL4^Hipk-BG00855/Hsap\HIPK4^UAS.Tag:MYC

(Kinsey et al., 2021)

Hipk^BG00855/Hipk⁴ has ocellus | pharate adult stage | absent phenotype, non-suppressible by Scer\GAL4^Hipk-BG00855/Hsap\HIPK4^UAS.Tag:MYC

(Kinsey et al., 2021)

Suppressor of

Statement

Reference

Hipk^BG00855/hipk[+] is a suppressor of posterior crossvein phenotype of Dys^RNAi.NH2.UAS, Scer\GAL4^Act.PU

(Kucherenko et al., 2008)

Hipk^BG00855/hipk[+] is a suppressor of posterior crossvein phenotype of Dys^RNAi.C.UAS, Scer\GAL4^Tub.PU

(Kucherenko et al., 2008)

Other

Statement

Reference

Dys^E6, Hipk^BG00855/hipk[+] has posterior crossvein phenotype

(Kucherenko et al., 2008)

Dys^RNAi.NH2.UAS, Hipk^BG00855/hipk[+] has wing vein | ectopic phenotype

(Kucherenko et al., 2008)

Dys^RNAi.C.UAS, Hipk^BG00855/hipk[+] has wing vein | ectopic phenotype

(Kucherenko et al., 2008)

Additional Comments

Genetic Interactions

Statement

Reference

One copy of hipk^BG00855 strongly suppresses the detached posterior crossvein phenotype seen when Dys^{dsRNA.NH2.Scer\UAS} is expressed under the control of Scer\GAL4^Act.PU but produces extra wing vein material.

One copy of hipk^BG00855 strongly suppresses the detached posterior crossvein phenotype seen when Dys^{dsRNA.C.Scer\UAS} is expressed under the control of Scer\GAL4^tub.PU but produces extra wing vein material.

One copy of hipk^BG00855 in a Dys^E6/+ background results in posterior crossvein defects.

(Kucherenko et al., 2008)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

Hipk^BG00855/Hipk⁴ is partially rescued by Scer\GAL4^Hipk-BG00855/Hipk^{UAS.cTa.Tag:HA}

(Kinsey et al., 2021)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

12779

w¹¹¹⁸; P{GT1}Hipk^BG00855/TM6C, Sb¹ Tb¹

Kyoto

111488

y^d2 w¹¹¹⁸ P{ey-FLP.N}2 P{5xglBS-lacZ.38-1}TPN1; P{GT1}Hipk^BG00855 P{neoFRT}80B/TM6B, P{Car20y}TPN1, Tb¹

Notes on Origin

Discoverer

Comments

Precise excision of the insertion reverts the lethal phenotype.

(Lee et al., 2009)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

CG17090^BG00855

Hipk^BG00855

hipk¹

(Lee et al., 2009)

hipk^BG00855

(Kucherenko et al., 2008)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

Open Close